| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
In the developing mammalian neocortex, neurons born within the inner pseudostratified layer ventricular zone migrate long distance radially toward outer region to form orderly aligned six layers within the cortical plate. Given that proper lamination of neocortex depends on timely and sequential arrival of functionally distinct neurons at the brain surface, regulation of the speed of migrating neurons is important, although the underlying mechanism remains unclear. Our results indicate that the PDK1-Akt pathway plays a crucial role in regulation of neuronal motility possibly through regulation of microtubule stability/dynamics and nucleus-centrosome coupling.
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