Analysis of vertebral column segmentation by the floor plate in medaka
Project/Area Number |
23570251
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Developmental biology
|
Research Institution | Tokyo Institute of Technology |
Principal Investigator |
INOHAYA Keiji 東京工業大学, 生命理工学研究科, 助教 (70302958)
|
Project Period (FY) |
2011-04-28 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 発生・分化 / メダカ / 骨形成 / 脊椎発生 / 分節性 / Wnt / 骨芽細胞 |
Outline of Final Research Achievements |
The fu-2 is a spontaneous and recessive medaka mutant, which exhibits fused centra and the absence of the intervertebral ligaments. As a result of positional cloning analysis, the fu-2 locus was mapped to chromosome23, but it was not identified in the medaka ensemble database. This result indicates that the fu-2 locus is locating on unknown region of choromosomal end. Finally, two candidate genes for the fu-2 phenotype, which relate to the Wnt signaling pathway, were found in this unknown region.
|
Report
(5 results)
Research Products
(8 results)