| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Expansion of human cortex during evolution depends in large part in developmental program that enables elaboration of neural circuit. During the formation of 6-layered neocortical structure, newborn neurons depart the ventricular zone and migrate toward the pial surface. It is suggested that impairment of these steps leads to develop brain malformation or various mental disorders. However, detailed molecular mechanisms are remained to be elucidated. In this study, we identified RP58 transcriptional repressor as a novel regulator for radial neuronal migration and revealed that negative feedback regulation of transcriptional regulatory network including RP58 and Ngn2 was critical for this regulation.
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