Molecular Mechanisms of gene regulatory network during corticogenesis
Project/Area Number |
23570264
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Developmental biology
|
Research Institution | Tokyo Metropolitan Institute of Medical Science |
Principal Investigator |
OHTAKA-MARUYAMA Chiaki 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 主席研究員 (00281626)
|
Co-Investigator(Kenkyū-buntansha) |
OKADO Haruo 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 副参事研究員 (60221842)
|
Project Period (FY) |
2011-04-28 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 大脳皮質 / RP58 / 転写制御 / 放射状移動 / 多極性細胞 / 双極性細胞 / Ngn2 / Rnd2 / サブプレート / 神経細胞移動 / 転写抑制因子 / 脳発生 / イメージング / 大脳皮質形成 / 子宮内エレクトロポレーション |
Outline of Final Research Achievements |
Expansion of human cortex during evolution depends in large part in developmental program that enables elaboration of neural circuit. During the formation of 6-layered neocortical structure, newborn neurons depart the ventricular zone and migrate toward the pial surface. It is suggested that impairment of these steps leads to develop brain malformation or various mental disorders. However, detailed molecular mechanisms are remained to be elucidated. In this study, we identified RP58 transcriptional repressor as a novel regulator for radial neuronal migration and revealed that negative feedback regulation of transcriptional regulatory network including RP58 and Ngn2 was critical for this regulation.
|
Report
(5 results)
Research Products
(29 results)
-
-
-
[Journal Article] RP58 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Cerebral Cortex2013
Author(s)
Ohtaka-Maruyama C, Hirai S, Miwa A, Heng J l, Shitara H, Ishii R, Taya C, Kawano H, Kasai M, Nakajima K, Okado H
-
Journal Title
Cell Reports
Volume: 3
Pages: 458-471
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] RP58 regulates the Muultipolar-Bipolar Transition of New born Neurons in the Developing Cerebral Cortex2012
Author(s)
Chiaki Ohtaka-Maruyama, Shinobu Hirai, Akiko MIwa, Julian lk-Tsen Heng, Hiroshi Shitara, Rie Ishii, Choji Taya, Hitoshi Kawano, Masataka Kasai, Kazunori Nakajima, Haruo Okado
Organizer
Gordon Research Conference “Neural Development”
Place of Presentation
Salve Regina University, Newport, RI, USA
Year and Date
20120812-20120817
Related Report
-
-
-
-
[Presentation] RP58 controls neuronal migration through feedback regulation of Ngn2 transcription in the developing cerebral cortex2012
Author(s)
Chiaki Ohtaka-Maruyama, Shinobu Hirai, Akiko MIwa, Julian lk-Tsen Heng, Hiroshi Shitara, Rie Ishii, Choji Taya, Hitoshi Kawano, Masataka Kasai, Kazunori Nakajima, Haruo Okado
Organizer
第一回国際シンポジウム International Symposium "Neocortical Organization"
Place of Presentation
岡崎
Year and Date
2012, 3,12
Related Report
-
-
-
-
-
-
[Presentation] RP58 regulates the multipolar-bipolar transition of newborn neurons in the developing cerebral cortex
Author(s)
Chiaki Ohtaka-Maruyama, Shinobu Hirai, Akiko Miwa, Julian lk-Tsen Heng, Hiroshi Shitara, Rie Ishii, Choji Taya, Hitoshi Kawano, Masataka Kasai, Kazunori Nakajima, Haruo Okado
Organizer
第23回理研CDB meeting「Building multicellular systems from cellular cross-talk」
Place of Presentation
理研CDB (神戸)
Related Report
-
-
-