Evolution of coordinated regulation of microRNAs and transcription factors
| Project/Area Number |
23570273
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Evolutionary biology
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| Research Institution | Kagawa University |
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Principal Investigator |
IWAMA Hisakazu 香川大学, 総合生命科学研究センター, 准教授 (20398035)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | マイクロＲＮＡ / 転写因子 / 協調的遺伝子制御 / cis-element / 遺伝子進化 / マイクロRNA / 協調的制御 / ターゲット遺伝子 / 遺伝子制御網 / 行列 / 遺伝子の生成死滅過程 / ゲノムアライメント / HITS-CLIP / PAR-CLIP |
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| Research Abstract |
A method to identify the evolutionary period of origin of human microRNAs (miRNAs) was established based on the genome synteny information. Applying the method to the genomes of 43 species estimated the period of origin for each of 1433 human miRNAs. Based on the estimation, the categories of transcription factors significantly associated with the evolutionary periods of origin of human miRNAs were specified. Furthermore, the rate at which human miRNAs originated was shown to have two peaks at the early phase of mammalian evolution and at the initial phase hominoid evolution, suggesting the effects of the two periods on the human transcriptom.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Antitumor effect of metformin in esophageal cancer: In vitro study2013
Author(s)
Kobayashi M, Kato K, Iwama H, Fujihara S, Nishiyama N, Mimura S, Toyota Y, Nomura T, Nomura K, Tani J, Miyoshi Hi, Kobara H, Mori H, Murao K, Masaki T
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Journal Title
Int J Oncol
Volume: 42(2)
Issue: 2
Pages: 517-24
DOI
Related Report
Peer Reviewed
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[Journal Article] Prediction of protein-destabilizing polymorphisms by manual curation with protein structure.2012
Author(s)
Gough CA, Homma K, Yamaguchi-Kabata Y, Shimada MK, Chakraborty R, Fujii Y, Iwama H, Minoshima S, Sakamoto S, Sato Y, Suzuki Y, Tada-Umezaki M, Nishikawa K, Imanishi T, Gojobori T.
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Journal Title
PLoS One
Volume: 7
Issue: 11
Pages: e50445-e50445
DOI
Related Report
Peer Reviewed
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