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Evolution of coordinated regulation of microRNAs and transcription factors

Research Project

Project/Area Number 23570273
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Evolutionary biology
Research InstitutionKagawa University

Principal Investigator

IWAMA Hisakazu  香川大学, 総合生命科学研究センター, 准教授 (20398035)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
KeywordsマイクロRNA / 転写因子 / 協調的遺伝子制御 / cis-element / 遺伝子進化 / マイクロRNA / 協調的制御 / ターゲット遺伝子 / 遺伝子制御網 / 行列 / 遺伝子の生成死滅過程 / ゲノムアライメント / HITS-CLIP / PAR-CLIP
Research Abstract

A method to identify the evolutionary period of origin of human microRNAs (miRNAs) was established based on the genome synteny information. Applying the method to the genomes of 43 species estimated the period of origin for each of 1433 human miRNAs. Based on the estimation, the categories of transcription factors significantly associated with the evolutionary periods of origin of human miRNAs were specified. Furthermore, the rate at which human miRNAs originated was shown to have two peaks at the early phase of mammalian evolution and at the initial phase hominoid evolution, suggesting the effects of the two periods on the human transcriptom.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (21 results)

All 2014 2013 2012 2011

All Journal Article (8 results) (of which Peer Reviewed: 7 results) Presentation (12 results) Book (1 results)

  • [Journal Article] ヒト・マイクロRNA遺伝子ファミリーの進化と起源推定2014

    • Author(s)
      岩間久和
    • Journal Title

      生体の科学

      Volume: 65(1) Pages: 80-90

    • NAID

      40019980710

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Human microRNAs originated from two periods at accelerated rates in mammalian evolution2013

    • Author(s)
      Iwama H, Kato K, Imachi H, Murao K, Masaki T
    • Journal Title

      Molecular Biology and Evolution

      Volume: Vol.30(1) Pages: 613-626

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coordinated networks of microRNAs and transcription factors with evolutionary perspectives2013

    • Author(s)
      Iwama H
    • Journal Title

      Adv Exp Med Biol

      Volume: Vol.774 Pages: 169-187

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional double-autorepression feedforward circuits act for multicellularity and nervous system development2013

    • Author(s)
      Iwama H, Murao K, Imachi H, Ishida T
    • Journal Title

      BMC Genomics

      Volume: Vol.11(12) Pages: 228-228

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human microRNAs originated from two periods at accelerated rates in mammalian evolution2013

    • Author(s)
      Iwama H, Kato K, Imachi H, Murao K, Masaki T
    • Journal Title

      Mol Biol Evol

      Volume: 30(3) Issue: 3 Pages: 613-26

    • DOI

      10.1093/molbev/mss262

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Coordinated Networks of microRNAs and Transcription Factors with Evolutionary Perspectives.2013

    • Author(s)
      Iwama H.
    • Journal Title

      Adv Exp Med Biol.

      Volume: 774 Pages: 169-187

    • DOI

      10.1007/978-94-007-5590-1_10

    • ISBN
      9789400755895, 9789400755901
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antitumor effect of metformin in esophageal cancer: In vitro study2013

    • Author(s)
      Kobayashi M, Kato K, Iwama H, Fujihara S, Nishiyama N, Mimura S, Toyota Y, Nomura T, Nomura K, Tani J, Miyoshi Hi, Kobara H, Mori H, Murao K, Masaki T
    • Journal Title

      Int J Oncol

      Volume: 42(2) Issue: 2 Pages: 517-24

    • DOI

      10.3892/ijo.2012.1722

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prediction of protein-destabilizing polymorphisms by manual curation with protein structure.2012

    • Author(s)
      Gough CA, Homma K, Yamaguchi-Kabata Y, Shimada MK, Chakraborty R, Fujii Y, Iwama H, Minoshima S, Sakamoto S, Sato Y, Suzuki Y, Tada-Umezaki M, Nishikawa K, Imanishi T, Gojobori T.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 11 Pages: e50445-e50445

    • DOI

      10.1371/journal.pone.0050445

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 哺乳類進化過程でのヒト・マイクロRNA生起とターゲット配列との関連2013

    • Author(s)
      岩間久和、加藤清仁、井町仁美、村尾孝児、正木勉
    • Organizer
      日本遺伝学会第85回大会
    • Place of Presentation
      東京
    • Year and Date
      2013-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト・マイクロRNAの哺乳類進化における生起数とターゲット配列の相互関連2013

    • Author(s)
      岩間久和、加藤清仁、井町仁美、村尾孝児、正木勉
    • Organizer
      日本進化学会第15回大会
    • Place of Presentation
      茨城
    • Year and Date
      2013-08-30
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト・マイクロRNAの哺乳類進化における生起数とターゲット配列の相互関連2013

    • Author(s)
      岩間久和,加藤清仁,井町仁美,村尾孝児,正木 勉
    • Organizer
      本遺伝学会第85回大会
    • Place of Presentation
      茨城
    • Related Report
      2013 Annual Research Report
  • [Presentation] 哺乳類進化過程でのヒト・マイクロRNA生起とターゲット配列との関連2013

    • Author(s)
      岩間久和,加藤清仁,井町仁美,村尾孝児,正木 勉
    • Organizer
      日本進化学会第15回大会
    • Place of Presentation
      神奈川
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒト・マイクロRNA遺伝子セットにおける起源時期推定と形成の速度2012

    • Author(s)
      岩間久和、加藤清仁、井町仁美、村尾孝児、正木勉
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-09-24
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト・マイクロRNA遺伝子の比較ゲノムによる生起時期の推定2012

    • Author(s)
      岩間久和、加藤清仁、井町仁美、村尾孝児、正木勉
    • Organizer
      日本進化学会第14回大会
    • Place of Presentation
      東京
    • Year and Date
      2012-08-23
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト・マイクロRNA遺伝子セットにおける起源時期推定と形成の速度2012

    • Author(s)
      岩間久和,加藤清仁,井町仁美,村尾孝児,正木勉
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒト・マイクロRNA遺伝子の比較ゲノムによる生起時期の推定2012

    • Author(s)
      岩間久和,加藤清仁,井町仁美,村尾孝児,正木勉
    • Organizer
      日本進化学会第14回大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 二重自己抑制性のフィードフォワード遺伝子制御の多細胞性への関与とマイクロRNA寄与の可能性2011

    • Author(s)
      岩間久和、井町仁美、村尾孝児
    • Organizer
      日本遺伝学会第83回大会
    • Place of Presentation
      福岡
    • Year and Date
      2011-09-25
    • Related Report
      2013 Final Research Report
  • [Presentation] MicroRNA Networks Alter to Conform to Transcription Factor Networks Adding Redundancy and Reducing the Target Gene Repertoire for Coordinated Regulation2011

    • Author(s)
      H. Iwama, H. Imachi, K. Murao
    • Organizer
      Annual conference of the Society for Molecular Biology and Evolution
    • Place of Presentation
      京都
    • Year and Date
      2011-07-28
    • Related Report
      2013 Final Research Report
  • [Presentation] MicroRNA Networks Alter to Conform to Transcription Factor Networks Adding Redundancy and Reducing the Target Gene Repertoire for Coordinated Regulation.2011

    • Author(s)
      Hisakazu Iwama
    • Organizer
      Annual conference of the Society for Molecular Biology and Evolution 2011. Syposium Evolutionary Systems Biology.(招待講演)
    • Place of Presentation
      Kyoto, Japan.
    • Related Report
      2011 Research-status Report
  • [Presentation] 二重自己抑制性のフィードフォワード遺伝子制御の多細胞性への関与とマイクロRNA寄与の可能性.2011

    • Author(s)
      岩間久和
    • Organizer
      日本遺伝学会第83回大会
    • Place of Presentation
      京都府
    • Related Report
      2011 Research-status Report
  • [Book] MicroRNA Cancer Regulation: Advanced Concepts, Bioinformatics and Systems Biology Tools.2013

    • Author(s)
      Iwama H. 他(分担執筆)
    • Total Pages
      358
    • Publisher
      Springer
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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