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Cellular protein quality control mechanism and the evolution of chemokine CXCL1L gene

Research Project

Project/Area Number 23570275
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Evolutionary biology
Research InstitutionKumamoto University

Principal Investigator

NOMIYAMA Hisayuki  熊本大学, 大学院生命科学研究部, 講師 (00156225)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsケモカイン / 遺伝子進化 / アカゲザル / タンパク質発現 / 翻訳 / タンパク質発現抑制
Research Abstract

Cynomolgus monkeys have chemokine genes CXCL1 and CXCL1L generated recently by gene duplication, whereas other mammals such as humans have only CXCL1, and the CXCL1L is inactivated in those species. However, the CXCL1L of cynomolgus monkeys is transcribed but the mRNA is scarcely translated into a secreted protein. To ellucidate the mechanism of the suppression of the CXCL1L protein expression in cynomolgus monkeys, we therefore investigated the possibility of an involvement of cellular protein quality control mechanism in the suppression of the protein expression. Although we found that the number of ribosomes bound to the CXCl1L mRNA is reduced compared to the CXCL1 mRNA, the results show that the protein quality control mechanism is not involved in the suppression of protein expression.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (18 results)

All 2014 2013 2012 2011 Other

All Journal Article (14 results) (of which Peer Reviewed: 12 results,  Open Access: 1 results) Presentation (4 results)

  • [Journal Article] Mesenchymal stem cells markedly suppress inflammatory bone destruction in rats with adjuvant- induced arthritis2014

    • Author(s)
      Takano T, Li YJ, Kukita A, Yamaza T, Ayukawa Y, Moriyama K, Uehara N, Nomiyama H, Koyano K and Kukita T
    • Journal Title

      Lab Invest

      Volume: 94 Pages: 286-296

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] International Union of Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors2014

    • Author(s)
      Bachelerie F, Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Sparre-Ulrich AH, Locati M, Luster AD, Mantovani A, Matsushima K, Murphy PM, Nibbs R, Nomiyama H, Power CA, Proudfoot AE, Rosenkilde MM, Rot A, Sozzani S, Thelen M, Yoshie O and Zlotnik A
    • Journal Title

      Pharmacol Rev

      Volume: 66

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal stem cells markedly suppress inflammatory bone destruction in rats with adjuvant-induced arthritis2014

    • Author(s)
      Takano, T. Li, Y. J. Kukita, A. Yamaza, T. Ayukawa, Y. Moriyama, K. Uehara, N. Nomiyama, H. Koyano, K. and Kukita, T.
    • Journal Title

      Laboratory Investigation

      Volume: 94 Issue: 3 Pages: 286-296

    • DOI

      10.1038/labinvest.2013.152

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Systematic classification of vertebrate chemokines based on conserved synteny and evolutionary history2013

    • Author(s)
      Nomiyama H, Osada N and Yoshie O
    • Journal Title

      Genes Cells

      Volume: 18 Pages: 1-16

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome diversification mechanism of rodent and lagomorpha chemokine genes2013

    • Author(s)
      Shibata K, Nomiyama H, Yoshie O and Tanase S
    • Journal Title

      BioMed research international2013

      Volume: 2013 Pages: 856265-856265

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tunneling nanotube formation is essential for the regulation of osteoclastogenesis2013

    • Author(s)
      Takahashi A, Kukita A, Li YJ, Zhang JQ, Nomiyama H, Yamaza T, Ayukawa Y, Koyano K and Kukita T
    • Journal Title

      J Cell Biochem

      Volume: 114 Pages: 1238-1247

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome diversification mechanism of rodent and Lagomorpha chemokine genes.2013

    • Author(s)
      Kanako Shibata, Hisayuki Nomiyama, Osamu Yoshie, Sumio Tanase.
    • Journal Title

      BioMed Research International

      Volume: 2013 Pages: 856265-856265

    • DOI

      10.1155/2013/856265

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tunneling nanotube formation is essential for the regulation of osteoclastogenesis2013

    • Author(s)
      Takahashi, A. Kukita, A. Li, Y. J. Zhang, J. Q. Nomiyama, H. Yamaza, T. Ayukawa, Y. Koyano, K. and Kukita, T.
    • Journal Title

      Journal of Cellular Biochemistry

      Volume: 114 Issue: 6 Pages: 1238-1247

    • DOI

      10.1002/jcb.24433

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] International Union of Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors.2013

    • Author(s)
      Francoise Bachelerie, Adit Ben-Baruch, Amanda M. Burkhardt, Christophe Combadiere, Joshua M. Farber, Gerard J. Graham, Richard Horuk, Alexander Hovard Sparre-Ulrich, Massimo Locati, Andrew D. Luster, Alberto Mantovani, Kouji Matsushima, Philip M. Murphy, Robert Nibbs, Hisayuki Nomiyama, Christine A. Power et al.
    • Journal Title

      Pharmacological Reviews

      Volume: 66(1) Issue: 1 Pages: 1-79

    • DOI

      10.1124/pr.113.007724

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systematic classification of vertebrate chemokines based on conserved synteny and evolutionary history.2013

    • Author(s)
      Hisayuki Nomiyama et al.
    • Journal Title

      Gene to Cells

      Volume: 18(1) Issue: 1 Pages: 1-16

    • DOI

      10.1111/gtc.12013

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] CXCL5.2012

    • Author(s)
      野見山尚之,棚瀬純男
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 57(Suppl. 21) Pages: 287-291

    • Related Report
      2013 Final Research Report
  • [Journal Article] CXCL5.2012

    • Author(s)
      野見山尚之,瀬戸山千秋
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 57(Suppl. 21) Pages: 336-339

    • Related Report
      2013 Final Research Report
  • [Journal Article] A family tree of vertebrate chemokine receptors for a unified nomenclature2011

    • Author(s)
      Nomiyama H, Osada N and Yoshie O
    • Journal Title

      Dev Comp Immunol

      Volume: 35 Pages: 705-715

    • NAID

      120003039872

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A family tree of vertebrate chemokine receptors for a unified nomenclature2011

    • Author(s)
      Nomiyama H, Osada N, Yoshie O
    • Journal Title

      Dev Comp Immunol

      Volume: 35(7) Issue: 7 Pages: 705-715

    • DOI

      10.1016/j.dci.2011.01.019

    • NAID

      120003039872

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 齧歯類および重歯類ケモカインのゲノム多様化機構Diversification Mechanism of Rodent and Lagomorpha Chemokine Genes2012

    • Author(s)
      柴田佳菜子、野見山尚之、棚瀬純男 Shibata K, Nomiyama H and Yoshi O
    • Organizer
      日本分子生物学会
    • Place of Presentation
      福岡市福岡国際会議場
    • Year and Date
      2012-12-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 齧歯類および重歯類ケモカインのゲノム多様化機構2012

    • Author(s)
      柴田佳菜子、野見山尚之、棚瀬純男
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡市・福岡国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] 脊椎動物ケモカインシステムの進化における変遷 Evolutionary history of the vertebrate chemokine system2011

    • Author(s)
      野見山尚之、長田直樹、義江修 Nomiyama H, Osada N and Yoshie 0
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜市横浜国際会議場
    • Year and Date
      2011-12-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 脊椎動物ケモカインシステムの進化における変遷

    • Author(s)
      野見山尚之
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜市・横浜国際会議場
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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