Gene expression of transcription factors in the central nervous system of primates

• Project/Area Number: 23570282
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Physical anthropology
• Research Institution: Kyoto University
• Principal Investigator: OISHI Takao 京都大学, 霊長類研究所, 准教授 (40346036)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 大脳皮質 / 小脳 / 大脳基底核 / 海馬 / 発達 / DNAマイクロアレイ / 分子・遺伝 / マイクロアレイ / マカク / 発達・加齢

Research Abstract

Aging brought about increase in expression of immunity-related genes and decrease in expression of mitochondria- and synaptic transmission-related genes in the neocortex and the hippocampus of macaque monkeys. Gene expressions suggest that enhancement of mitochondrial function and remyelination occur in the human brain and deterioration of mitochondrial function and demyelination occur in the macaque brain.
In the macaque neocortex, neocortex-specific gene groups were expressed in addition to gene expressions in common with the hippocampus. There were no genes of transcription factor whose expression was in concordance with the process of myelination or demyelination. Estrogen and related substances may regulate gene expressions of transcription factors, whose expression was in concordance with the degree of myelination.

Research Products

• [Journal Article] Functional Annotation of Genes Differentially Expressed Between Primary Motor and Prefrontal Association Cortices of Macaque Brain (2013)
  • Author(s): Toshio Kojima
  • Journal Title: Neurochemical Research Volume: 38 Issue: 1 Pages: 133-140
  • DOI: 10.1007/s11064-012-0900-4
  • Peer Reviewed
• [Journal Article] Differential Expression of Secreted Phosphoprotein l in the Motor Cortex among Primate Species and during Postnatal Development and Functional Recovery (2013)
  • Author(s): T. Yamamoto, T. Oishi, N. Higo, S. Murayama, A. Sato, I. Takashima, Y. Sugiyama, Y. Nishimura, Y. Murata, K. Yoshino-Saito, T. Isa, T. Kojima
  • Journal Title: PLOS ONE Volume: 8(5) Issue: 5 Pages: 1-13
  • DOI: 10.1371/journal.pone.0065701
  • Peer Reviewed
• [Journal Article] Effects of early versus late rehabilitative training on manual dexterity after corticospinal tract lesion in macaque monkeys (2013)
  • Author(s): Sugiyama Y, Higo N, Yoshino-Saito K, Murata Y, Nishimura Y, Oishi T, Isa T
  • Journal Title: Journal of Neurophysiology Volume: 109 Pages: 2853-2865
  • Peer Reviewed
• [Journal Article] Response of Erβ and aromatase expression in the monkey hippocampal formation to ovariectomy and menopause (2012)
  • Author(s): Higaki S., Takumi K., Itoh M., Shimizu K., Oishi T., Hayashi M.
  • Journal Title: Neuroscience Research Volume: 72 Issue: 2 Pages: 148-154
  • DOI: 10.1016/j.neures.2011.10.007
  • NAID: 120003874260
  • Peer Reviewed
• [Journal Article] Ultrasound safety with midfrequency transcranial sonothrombolysis: preliminary study on normal macaca monkey brain (2012)
  • Author(s): Shimizu J, Fukuda T, Abe T, Ogihara M, Kubota J, Sasaki A, Azuma T, Sasaki K, Shimizu K, Oishi T, Umemura S, Furuhata H
  • Journal Title: Ultrasound in Medicine & Biology Volume: 38 Issue: 6 Pages: 1040-1050
  • DOI: 10.1016/j.ultrasmedbio.2012.02.009
  • Peer Reviewed
• [Journal Article] 脳とこころ－脳の進化から考える－ (2012)
  • Author(s): 大石高生
  • Journal Title: 椙山人間学研究 Volume: 7 Pages: 82-92
• [Journal Article] Distribution and pharmacological characterization of primate NK-2 tachykinin receptor in the central nervous system of the rhesus monkey (2011)
  • Author(s): Nagano M, Oishi T, Suzuki H
  • Journal Title: Neurosci Lett Volume: 503 Issue: 1 Pages: 23-26
  • DOI: 10.1016/j.neulet.2011.07.057
  • Peer Reviewed
• [Journal Article] Gender differences in the phosphorus content of the sino-atrial nodes and other cardiac regions of monkeys. (2011)
  • Author(s): Tohno Y, Tohno S, Satoh H, Hayashi M, Oishi T, Minami T, Mahakkanukrauh P.
  • Journal Title: Biological Trace Element Research Volume: 143 Issue: 2 Pages: 871-881
  • DOI: 10.1007/s12011-010-8908-6
  • Peer Reviewed
• [Journal Article] Flybrain neuron database : a comprehensive database system of the Drosophila brain neurons (2011)
  • Author(s): Shinomiya, K., Matsuda, K., Oishi, T., Otsuna, H., Ito, K.
  • Journal Title: J Comp Neurol Volume: 519 Issue: 5 Pages: 807-833
  • DOI: 10.1002/cne.22540
  • Peer Reviewed
• [Presentation] Gene expression of the transcription factors in the monkey cerebral cortex during postnatal development (2014)
  • Author(s): Takao Oishi, Sayuri Higaki, Akira Sato, Shinji Kondo, Toshio Kojima
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島
  • Year and Date: 2014-03-18
• [Presentation] Sporadic premature aging in a Japanese monkey (2013)
  • Author(s): Takao Oishi, Hiroo Imai, Hirohisa Hirai, Masahiko Takada
  • Organizer: he 3rd NIPS-CIN Joint Neuroscience Symposium
  • Place of Presentation: 岡崎
• [Presentation] 脊髄路損傷モデルザルにおける大脳皮質運動野から脊髄への越シナプス的入力様式 (2013)
  • Author(s): 二宮太平 中川浩 上野将紀 西村幸男 大石高生 山下俊英 高田昌彦
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] マカク中枢神経系の遺伝子発現の発達変化の解析 (2012)
  • Author(s): 大石高生,佐藤明,檜垣小百合,近藤伸二,小島俊男
  • Organizer: 第59回中部日本生理学会
  • Place of Presentation: 岡崎
  • Year and Date: 2012-11-16
• [Presentation] Gene network analysis of genes differentially expressed between primary motor and prefrontal association cortices of macaque brain (2012)
  • Author(s): T. Kojima, N. Higo, A. Sato, T. Oishi, Y. Nishimura, T. Yamamoto, Y. Murata, K. Yoshino-Saito, H. Onoe, T. Isa
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2012-10-17
• [Presentation] サル中枢神経系の遺伝子発現の発達の部位間比較 (2012)
  • Author(s): 大石高生,佐藤明,檜垣小百合,近藤伸二,小島俊男
  • Organizer: 第35回日本神経科学大会名古屋市学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-20
• [Presentation] 健常及び運動皮質損傷マカクサルにおけるSPP1の局在の違い (2012)
  • Author(s): 杉山容子,大石高生,山下晶子,村田弓,山本竜也,伊佐正,肥後範行
  • Organizer: 第35回日本神経科学大会名古屋市学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-18
• [Presentation] サル中枢神経系の遺伝子発現の発達の部位間比較 (2012)
  • Author(s): 大石高生, 佐藤明, 檜垣小百合, 近藤伸二, 小島俊男
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋市
• [Presentation] マカク中枢神経系の遺伝子発現の発達変化の解析 (2012)
  • Author(s): 大石高生, 佐藤明, 檜垣小百合, 近藤伸二, 小島俊男
  • Organizer: 第59回中部日本生理学会
  • Place of Presentation: 岡崎市
• [Presentation] 健常及び運動皮質損傷マカクサルにおけるSPP1の局在の違い (2012)
  • Author(s): 杉山容子, 大石高生, 山下 晶子, 村田弓, 山本竜也, 伊佐 正, 肥後範行
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋市
• [Presentation] マカクザルにおける脊髄損傷後の機能回復に関与する神経回路再編成と機能分子発現 (2012)
  • Author(s): 二宮太平, 中川浩, 上野将紀, 西村幸男, 大石高生, 山下俊英, 高田昌彦
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋市
• [Presentation] The role of the ventral premotor area after primary motor cortex lesion in macaque monkeys: Involvement in functional compensation of grasping (2012)
  • Author(s): Y. Murata, N. Higo, T. Hayashi, Y. Nishimura, Y. Sugiyama, T. Oishi, H. Tsukada, T. Isa, H. Onoe
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, USA
• [Presentation] Neural basis for functional compensation after spinal cord injury in macaques (2012)
  • Author(s): T. Ninomiya, H. Nakagawa, M. Ueno, Y. Nishimura, T. Oishi, T. Yamashita, M. Takada
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, USA
• [Presentation] マカクザル運動関連皮質領野における遺伝子発現のマイクロアレイ法による網羅的解析 (2011)
  • Author(s): 伊佐正、小島俊男、肥後範行、大石高生、尾上浩隆
  • Organizer: マカクザル運動関連皮質領野における遺伝子発現のマイクロアレイ法による網羅的解析
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-17
• [Presentation] 第一次運動野損傷後の把握動作回復に対する運動前野腹側部の関わり (2011)
  • Author(s): 村田弓、肥後範行、西村幸男、林拓也、杉山容子、大石高生、塚田秀夫、伊佐正、尾上浩隆
  • Organizer: 包括脳ネットワーク夏のワークショップ
  • Place of Presentation: 神戸国際会議場（神戸市）
• [Presentation] マカクザル運動関連皮質領野における遺伝子発現のマイクロアレイ法による網羅的解析 (2011)
  • Author(s): 伊佐正、小島俊男、肥後範行、大石高生、尾上浩隆
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] Plastic changes in the ventral premotor area after primary motor cortex lesion in macaque monkeys: possible involvement in functional compensation of manual dexterity (2011)
  • Author(s): Yumi Murata, Noriyuki Higo, Takuya Hayashi, Yukio Nishimura, Yoko Sugiyama, Takao Oishi, Hideo Tsukada, Tadashi Isa, Hirotaka Onoe
  • Organizer: Neuroscience 2011
  • Place of Presentation: Walter E. Washington Convention Center (Washington D.C., USA)
• [Presentation] 幼若マカクサル外側前頭前野への皮質―皮質入力 (2011)
  • Author(s): 宮地重弘、平田快洋、檜垣小百合、黒田呈子、宮部貴子、高田昌彦、大石高生
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Remarks]
  • URL: http://kyouindb.iimc.kyoto-u.ac.jp/j/gI9wX
• [Remarks] 京都大学 教育研究活動データベース（大石高生）
  • URL: http://kyouindb.iimc.kyoto-u.ac.jp/j/gI9wX