Roles of a vesicular transport network and a membrane fusion in autophagy in Saccharomyces cerevisiae
| Project/Area Number |
23580099
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Tohoku University |
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Principal Investigator |
SHINTANI Takahiro 東北大学, (連合)農学研究科(研究院), 准教授 (70374973)
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| Co-Investigator(Renkei-kenkyūsha) |
GOMI Katsuya 東北大学, 大学院農学研究科, 教授 (60302197)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | オートファジー / SNARE / 出芽酵母 |
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| Research Abstract |
We found that autophagy was inhibited when the secretory pathway was blocked in several SNARE (soluble NSF attachment protein receptor) mutants, suggesting that a supply of membrane lipid from the secretory pathway might be important for autophagosome formation. We also showed that some SNARE proteins directly associated with Atg9, which plays roles in autophagosome formation, at preautophagosomal structure, suggesting that these proteins might function as machinery of autophagosome formation.
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Report
(4 results)
Research Products
(19 results)
