Metabolic mechanism of host extracellular matrices, glycosaminoglycans, in streptococci
| Project/Area Number |
23580112
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Kyoto University |
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Principal Investigator |
HASHIMOTO Wataru 京都大学, (連合)農学研究科(研究院), 准教授 (30273519)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 連鎖球菌 / 宿主細胞外マトリックス / グリコサミノグリカン / 代謝機構 / イソメラーゼ / 還元酵素 / X線結晶構造解析 / 不飽和グルクロニルヒドロラーゼ / 応用微生物学 / 微生物代謝 / 構造生物学 / 代謝酵素 / 遺伝子クラスター / 構造機能相関 / 異性化酵素 / 細胞外マトリックス / 感染症 |
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| Research Abstract |
Pathogenic streptococci degrade host extracellular matrices, glycosaminoglycans, to unsaturated uronic acid and amino sugar by polysaccharide lyase and unsaturated glucuronyl hydrolase (UGL). Unsaturated uronic acid was found metabolized to 2-keto-3-deoxy-D-gluconic acid through subsequent reaction of Gbs1892 isomerase and Gbs1891 reductase. These enzymes were encoded in the UGL genetic cluster, suggesting that repression of this cluster contributes to establishment of a novel therapy for strectococcal infectious diseases.
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Report
(4 results)
Research Products
(41 results)
