| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
The transcriptome analysis with the deletion mutants of hha, ydgT, stpA and hns genes indicated that Hha and YdgT are the proteins which assist H-NS to repress the expression over 100 genes. In addition, lux and lacZ reporter analysis to elucidate the mechanisms of the transcriptional regulations in ybdO and ler promoters indicated that the wide areas in up and downstream of the ybdO promoter is essential for the transcriptional repression of ybdO which depends on H-NS and the derepression of ler promoter with Pch protein observed when the repression of ler genes was cooperatively regulated by H-NS and Hha.
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