The mechanism underlying the cell shape change mediated by an oligomerizing molecule
| Project/Area Number |
23580130
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IHARA Sayoko 東京大学, 農学生命科学研究科, 助教 (80292788)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 細胞膜 / アクチン / 生体膜 / 細胞骨格 / 重合 |
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| Outline of Final Research Achievements |
Cells change their morphology in response to the outer stimuli. SWAP-70 has been known to play an important role in the regulation of cell shape change through the binding to both of the cell membrane and actin cytoskeleton. In this study, we show that SWAP-70 oligomerizes prior to actin polymerization in response to growth factor stimulation. The binding to activated Rac was shown to be required for the oligomerization of SWAP-70 and growth factor-induced cell shape change, suggesting the contribution of oligomerization of SWAP-70 to the stimulus-dependent cell shape change.
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Report
(5 results)
Research Products
(2 results)
