The mechanism underlying the cell shape change mediated by an oligomerizing molecule

Research Project

Project/Area Number	23580130
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Applied biochemistry
Research Institution	The University of Tokyo
Principal Investigator	IHARA Sayoko 東京大学, 農学生命科学研究科, 助教 (80292788)
Project Period (FY)	2011-04-28 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	細胞膜 / アクチン / 生体膜 / 細胞骨格 / 重合
Outline of Final Research Achievements	Cells change their morphology in response to the outer stimuli. SWAP-70 has been known to play an important role in the regulation of cell shape change through the binding to both of the cell membrane and actin cytoskeleton. In this study, we show that SWAP-70 oligomerizes prior to actin polymerization in response to growth factor stimulation. The binding to activated Rac was shown to be required for the oligomerization of SWAP-70 and growth factor-induced cell shape change, suggesting the contribution of oligomerization of SWAP-70 to the stimulus-dependent cell shape change.

Report

(5 results)