| Project/Area Number |
23580141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
TAKAHASHI YUJI 東京薬科大学, 生命科学部, 教授 (20154875)
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| Co-Investigator(Kenkyū-buntansha) |
MARIKO Umemura 東京薬科大学, 生命科学部, 助教 (30521489)
HARUO Nakano 東京薬科大学, 生命科学部, 助教 (60601870)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | ストレス応答 / 転写調節因子 / 自閉症スペクトラム / 嗅球 / ATF5 / 糸球体 / 介在ニューロン / 学習行動 / 不安行動 / 多動 / 社会性行動 / 自閉症 / 飢餓応答 / レンチウィルス |
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| Research Abstract |
Activating Transcription Factor 5 (ATF5), starvation-induced stress-responsive transcription factor, is expressed strongly in the subventricular zone and weekly in the wide range of the brain. Olfactory neurons in olfactory epithelium also express ATF5 abundantly. We made ATF5-deficent congenic mice and used them to test behavioral characteristics, including anxiety, perseveration, social contact, working memory and reference memory. ATF5-deficient mice showed hyperactivity, strong anxiety, depressed social activity and strong tendency of perseveration, independent of working and reference memories. These behavioral features indicate that ATF5-deficient mice show autism spectrum-like behavioral abnormality. Histochemical examination of the odorant bulb of ATF5-defficient mice revealed that ATF5 is involved in the neural activity of odorant perception.
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