Starvation stress-responsive transcription factor is involved in the regulation of memory-independent social behavior of mouse

• Project/Area Number: 23580141
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied biochemistry
• Research Institution: Tokyo University of Pharmacy and Life Science
• Principal Investigator: TAKAHASHI YUJI 東京薬科大学, 生命科学部, 教授 (20154875)
• Co-Investigator(Kenkyū-buntansha): MARIKO Umemura 東京薬科大学, 生命科学部, 助教 (30521489) ; HARUO Nakano 東京薬科大学, 生命科学部, 助教 (60601870)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: ストレス応答 / 転写調節因子 / 自閉症スペクトラム / 嗅球 / ATF5 / 糸球体 / 介在ニューロン / 学習行動 / 不安行動 / 多動 / 社会性行動 / 自閉症 / 飢餓応答 / レンチウィルス

Research Abstract

Activating Transcription Factor 5 (ATF5), starvation-induced stress-responsive transcription factor, is expressed strongly in the subventricular zone and weekly in the wide range of the brain. Olfactory neurons in olfactory epithelium also express ATF5 abundantly. We made ATF5-deficent congenic mice and used them to test behavioral characteristics, including anxiety, perseveration, social contact, working memory and reference memory. ATF5-deficient mice showed hyperactivity, strong anxiety, depressed social activity and strong tendency of perseveration, independent of working and reference memories. These behavioral features indicate that ATF5-deficient mice show autism spectrum-like behavioral abnormality. Histochemical examination of the odorant bulb of ATF5-defficient mice revealed that ATF5 is involved in the neural activity of odorant perception.

Research Products

• [Journal Article] N-terminal hydrophobic amino acids of ATF5 confer IL-1b-induced stabilization (2014)
  • Author(s): Abe T., Kojima M., Akanuma S., Iwashita H., Yamazaki T., Okuyama R., Ichikawa K., Umemura M., Nakano H., Takahashi S., and Takahashi Y.
  • Journal Title: J Biol Chem Volume: 289 Pages: 3888-3900
  • Peer Reviewed
• [Journal Article] N-terminal hydrophobic amino acids of ATF5 confer IL-1β-induced stabilization (2014)
  • Author(s): Abe T., Kojima M., Akanuma S., Iwashita H., Yamazaki T., Okuyama R., Ichikawa K., Umemura M., Nakano H., Takahashi S., and Takahashi Y.
  • Journal Title: Journal of Biological Chemistry Volume: 289 Pages: 3888-3900
  • Peer Reviewed
• [Journal Article] The 5'-untranslated region regulates ATF5 mRNA stability via nonsense-mediated mRNA decay in response to environmental stress (2013)
  • Author(s): Hatano M., Umemura M., Kimura N., Yamazaki T., Takeda H., Nakano H., Takahashi S., and Takahashi Y.
  • Journal Title: FEBS J Volume: 280 Issue: 18 Pages: 4693-4707
  • DOI: 10.1111/febs.12440
  • Peer Reviewed
• [Journal Article] Phenolic diterpenes from rosemary suppress cAMP responsiveness of gluconeogenic gene promoters (2013)
  • Author(s): Yun YS., Noda S., Shigemori G., Kuriyama R., Takahashi S., Umemura M., Takahashi Y., and Inoue H.
  • Journal Title: Phytother Res Volume: 27 Issue: 6 Pages: 906-910
  • DOI: 10.1002/ptr.4794
  • Peer Reviewed
• [Journal Article] Determination and physiological roles of the glycosylphosphatidylinositol lipid remodeling pathway in yeast (2013)
  • Author(s): Yoko-o, T., Ichikawa, D., Miyagishi, Y., Kato, A., Umemura, M., Takase, K., Ra, M., Ikeda, K., Taguchi, R. and Jigami, Y.
  • Journal Title: Molecular Microbiology Volume: 88 Issue: 1 Pages: 140-155
  • DOI: 10.1111/mmi.12175
  • Peer Reviewed
• [Journal Article] Gain-of-function screening identify miR-193a regulating proliferation and apoptosis in epithelial ovarian cancer cells (2013)
  • Author(s): Nakano H., Ymamada Y., Miyazawa T., Yoshida T.
  • Journal Title: Int. J. Oncol Volume: 42 Issue: 6 Pages: 1875-1882
  • DOI: 10.3892/ijo.2013.1896
  • Peer Reviewed
• [Journal Article] A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta (2013)
  • Author(s): Lu J., Zhang S., Nakano H., Simmons D.G., Wang S., Kong S., Wang Q., Shen L., Tu Z., Wang W., Wang B., Wang H., Wang Y., van Es J. H., Clevers H., Leone G., Cross J.C., Wang H.
  • Journal Title: PLOS Biol Volume: 11 Issue: 4 Pages: e1001536-e1001536
  • DOI: 10.1371/journal.pbio.1001536
  • Peer Reviewed
• [Journal Article] The 5'-untranslated region regulates ATF5 mRNA stability via nonsense-mediated mRNA decay in response to environmental stress, (2013)
  • Author(s): Hatano M., Umemura M., Kimura N., Yamazaki T., Takeda H., Nakano H., Takahashi S., and Takahashi Y.
  • Journal Title: FEBS J Volume: 280 Pages: 4693-4707
  • Peer Reviewed
• [Journal Article] Detection of vertebrate-type sterid hormones and their converting activity in the neogastropid, Thais clavigera (2012)
  • Author(s): Goto, Y., Kajiwara, M., Yanagisawa, Y., Hirose, H., Yoshimi, T., Umemura, M., Nakano, H., Takahashi, S., Shida, Y., Iguchi, T., Takahashi, Y., Miura T.
  • Journal Title: J. Mol. Studies Volume: 78 Issue: 2 Pages: 197-204
  • DOI: 10.1093/mollus/eys001
  • Peer Reviewed
• [Journal Article] A potent 2'-O-methylated RNA-based microRNA inhibitor with unique secondary structures (2012)
  • Author(s): Haraguchi,T., Nakano, H., Tagawa, T., Ohki, T., Ueno, Y., Yoshida, T., Iba, H.
  • Journal Title: Nucleic Acids Res. Volume: (in press) Issue: 8 Pages: 1-13
  • DOI: 10.1093/nar/gkr1317
  • Peer Reviewed
• [Presentation] 転写因子ATF5による嗅覚受容体の発現調節 (2014)
  • Author(s): 金子将人、雨宮ゆう子、中野春男、梅村真理子、高橋滋、高橋勇二
  • Organizer: 日本農芸化学会2014年度大会
  • Place of Presentation: 東京
• [Presentation] マウス鋤鼻細胞の増殖とアポトーシスに関与する転写因子ATF5 (2014)
  • Author(s): 鈴木誠人、飯田吉剛、青木満里恵、笹川洋、中野春男、梅村真理子、高橋滋、高橋勇二
  • Organizer: 日本農芸化学会2014年度大会
  • Place of Presentation: 東京
• [Presentation] IL-1bによるATF5タンパク質安定化の免疫応答における役割 (2013)
  • Author(s): 阿部貴則、岩下弘実、奥山隆一、山崎高志、高橋滋、高橋勇二
  • Organizer: 日本生化学会関東支部例会
  • Place of Presentation: 甲府市
• [Presentation] ATF5欠損マウスの脳内モノアミン量の解析 (2013)
  • Author(s): 森直人、梅村真理子,松崎彩子,中野春男,高橋滋,高橋勇二
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] 軟体動物の組織再生に関わるレチノイン酸シグナルおよび幹細胞関連因子の解析 (2013)
  • Author(s): 中間翼、関百恵、渡邊弘明、伊東翼、金子浩子、梅村真理子、中野春男、高橋滋、高橋勇二
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] マウス鋤鼻器における転写因子ATF5の機能解析 (2013)
  • Author(s): 飯田吉剛,鈴木誠人,青木満里恵,笹川洋,中野春男,梅村真理子,高橋滋,高橋勇二
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] Involvement of retinoic acid pathway in tissue regeneration of Thais clavigera (2012)
  • Author(s): Watanabe, H., Itou, T., Nagasawa, K., Kaneko, H., Mizukami, K., Aya Saiga, A., Nakano, H., Umemura, M., Shigeru Takahashi, S., Takahashi, Y.
  • Organizer: Gordon Research Conference on Environmental Endocrine Disruptors
  • Place of Presentation: New Hampshire, USA
• [Presentation] ATF5/C/EBPγheterodimer regulates sodium-arsenite induced DR5 gene expression in human hepatoma cells (2012)
  • Author(s): 山﨑高志、阿部貴則、中野春男、梅村真理子、高橋滋、高橋勇二
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 博多
• [Presentation] ATF5 mRNA発現調節機構における翻訳開始点の変動とNMDの寄与 (2012)
  • Author(s): 幡野仁哉,梅村真理子,鈴木実菜子,中野春男,高橋滋,高橋勇二
  • Organizer: 日本農芸化学会2012年度大会
  • Place of Presentation: 京都
• [Presentation] 環境ストレスによるC/EBPγmRNAの安定化制御 (2012)
  • Author(s): 大川佳子、山﨑高志、中野春男、梅村真理子、高橋滋、高橋勇二
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 博多
• [Presentation] The 5'-untranslated region regulates the stability of ATF5mRNA by nonsense-mediated mRNA decay (2011)
  • Author(s): Umemura, M., Hatano, M., Kimura, N., Yamazaki, T., Takeda, H., Nakano, H., Takahashi, S., Takahashi, Y.
  • Organizer: Cold spring harbor laboratory the 2011 meeting on eukaryotic mRNA processing
  • Place of Presentation: New York, USA
• [Presentation] Regulation of C/EBPγmRNA stability by environmental stresses (2011)
  • Author(s): Yamazaki, T., Okawa, Y.,Watanabe, R., Murakoso, S., Nakano, H., Takahashi, S., Takahashi, Y.
  • Organizer: Cold spring harbor laboratory the 2011 meeting on eukaryotic mRNA processing
  • Place of Presentation: New York, USA
• [Presentation] 嗅覚系の発達におけるATF5の機能解明 (2011)
  • Author(s): 恒松加奈子、梅村真理子、清水悠介、中野春男、高橋滋、東浦康友、岡部勝、高橋勇二
  • Organizer: 第34回に本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] IL-1bによるATF5タンパク質安定化の免疫応答における役割
  • Author(s): 阿部貴則、岩下弘実、奥山隆一、山崎高志、高橋滋、高橋勇二
  • Organizer: 日本生化学会 関東支部例会
  • Place of Presentation: 甲府市
• [Book] 最新栄養学第10版建帛社2014年翻訳担当第36章ヨウ素とその欠乏による障害
• [Remarks] ホームページ
  • URL: http://logos.ls.toyaku.ac.jp/Life-Science/lemp-4/