| Project/Area Number |
23580150
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Tottori University |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
IWASAKI Takashi 鳥取大学, 農学部, 助教 (30585584)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
ISHIGURO Masaji 新潟薬科大学, 応用生命化学部, 教授 (10280687)
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | インスリン / 寿命 / 休眠 / 線虫 / インスリン様分子 / ペプチドホルモン |
|---|
| Research Abstract |
Insulin/IGF-1 signaling is known to regulate larval diapause and lifespan of the nematode Caenorhabditis elegans. So far, 40 of insulin-like genes have been identified in C. elegans. So far, 40 of insulin-like genes have been identified in C. elegans. In order to identify an insulin-like molecule which physiological function is unknown as well as to elucidate how insulin-like molecules co-operatively regulate diapause and lifespan, we performed three experiments as follows. 1, a functional analysis in "molecular level" using molecular modeling; 2, a functional analysis in "cellular level" using a primary culture; 3, a functional analysis in "organism level" using molecular biological technics. Moreover, we proposed a model for regulatory mechanism of expression of an insulin-like gene.
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