• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Functional analysis of novel terpene cyclases that resemble transporter

Research Project

Project/Area Number 23580153
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Bioproduction chemistry/Bioorganic chemistry
Research InstitutionMeiji University

Principal Investigator

KUSHIRO Tetsuo  明治大学, 農学部, 准教授 (80373299)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsメロテルペノイド / 糸状菌 / テルペン環化酵素 / ポリケタイド / 生合成
Research Abstract

Pyripyropene, produced by a fungus Aspergillus fumigatus, is a meroterpenoid that is expected to be developed as a cholesterol lowering drug. Among the pyripyropene biosynthetic gene cluster, a novel terpene cyclase was identified that resembled more like a transporter. In this study, detailed analysis of its active site residue was carried out. Besides, a second meroterpenoid biosynthetic gene cluster was identified from A. fumigatus as well as from a fungus Fusarium graminearum, which causes Fusarium head blight. The PKS among the second gene cluster in A. fumigatus was shown to produce TAL.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (1 results)

All 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Identification of a key prenyltransferase involved in biosynthesis of the most abundant fungal meroterpenoids derived from 3,5-dimethylorsellinic acid2012

    • Author(s)
      Itoh, T.
    • Journal Title

      ChemBioChem

      Volume: 13 Issue: 8 Pages: 1132-1135

    • DOI

      10.1002/cbic.201200124

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi