| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
A research that controls the molecular properties by the fluorous content in the molecule (fluoromix concept) was performed to achieve the energy-saving molecular synthesis. As a result, we got the following results.
1) Fluorous Mukaiyama reagent, which can achieve an easy condensation system, was developed. In this condensation reaction, the product can be isolated effectively from by-products after the reaction. 2) We found a divergent synthesis method of Fmoc reagents, which have different fluorous tags. 3) A concise liquid-phase combinatorial synthesis of all stereoisomers of tenuecyclamide A was achieved using a mixture of D/L-alanine with each stereoisomer encoded by a different f-Fmoc tag.
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