Molecular modeling of anti-amyloidal catechol derivatives using amyloidogenic proteins
| Project/Area Number |
23580161
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJII Hiroshi 信州大学, 農学部, 教授 (90165340)
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| Co-Investigator(Renkei-kenkyūsha) |
HIGUCHI Keiichi 信州大学, 医学系研究科, 教授 (20173156)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | アミロイド性蛋白質 / 抗アミロイド効果 / カテコール誘導体 / 分子モデリング / 抗アミロイドーシス食品素材 |
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| Research Abstract |
Molecular modeling of anti-amyloidal catechol derivatives was performed using Amyloid-beta, ApoA-II, human cystatin C and stefin B as model proteins. We prepared enzymatic lipophilized/glycosylated phenolic compounds in addition to mono- and di-catecholates of sesamin, and used for anti-amyloidal experiments. As the result, we found that there was a strong relationship between amphiphilicity and anti-amyloidal activity of tested phenolic compounds. We also found that lipophilic chain length introduced was an important factor in the anti-amyloidal activity of novel catechol derivatives.
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Report
(4 results)
Research Products
(24 results)
