The important roles of intestinal cells in responses to dietary fibers
| Project/Area Number |
23580163
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Gifu University |
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Principal Investigator |
YABE Tomio 岐阜大学, 応用生物科学部, 准教授 (70356260)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 食物繊維 / ペクチン / フィブロネクチン / Caco-2細胞 / ヘパラン硫酸 / インテグリン / ポリアミン / 表面プラズモン共鳴 |
|---|
| Research Abstract |
We found that intestinal epithelial cells recognized a pectic polysaccharide through the fibronectin located around tight junctions and altered sulfated structure of heparan sulfate on the cell surface through integrin. These findings show that functions of dietary fiber are not only exerted by physicochemical properties or enterobacteria.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Simple Method for Refining Arabinan Polysaccharides by Alcohol Extraction of the Prune, <i>Prunus domestica</i> L.2013
Author(s)
Hara, Y., Mizukawa, H., Yamamoto, H., Ikami, T., Kato, K., and Yabe, T.
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 77
Issue: 10
Pages: 2137-2139
DOI
NAID
ISSN
0916-8451, 1347-6947
Related Report
Peer Reviewed
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[Presentation] A specific structure in the pectin from prune recognizes fibronectin and affects on the expression level of polyamines in Caco-2 cells2013
Author(s)
Yabe, T., Itoh, C., Honda, A., Ishikawa, M., Nakamura, A., Yamamoto, H., Ikami, T., and Kanamaru, Y.
Organizer
EPNOE 2013 International Polysaccharides Conference
Place of Presentation
Nice, France
Year and Date
2013-10-24
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