Regulation of physiological functions with food factors via molecular chaperones
| Project/Area Number |
23580164
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Food science
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
MURAKAMI Akira 京都大学, (連合)農学研究科(研究院), 助教 (10271412)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | zerumbone / heat shock protein / proteasome / autophagy / hormesis / stress / target molecule / molecular chaperone / 分子シャペロン / 熱ショックタンパク質 / ユビキチン・プロテアソーム / ゼルンボン / ストレス耐性 / プロテオストレス / ファイトケミカル / オートファジー / proteostress / stress resistance / phytochemical / heat shock response / ストレス応答 / 求電子性物質 / 線虫 / ケミカルストレス |
|---|
| Research Abstract |
Although phytochemicals have been reported to exhibit various physiological functions, their underlying mechanisms remain to be fully elucidated. We previously identified Keap1 as a target molecule of zerumbone, a major component of Zingiber zerumbet. Concomitantly, however, we also observed numerous binding proteins when cells were exposed to this phytochemical. Thus this study focused on the role(s) of non-specific protein binding in its bioactivities. Interestingly, zerumbone-induced proteo-stress up-regulated the expressions of molecular chaperones and increased autophagy for degradation of abnormal proteins. This is the first study that showed phytochemical-induced proteo-stress has significant and unique roles in their bioactivities.
|
Report
(4 results)
Research Products
(34 results)
