| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Research Abstract |
Although phytochemicals have been reported to exhibit various physiological functions, their underlying mechanisms remain to be fully elucidated. We previously identified Keap1 as a target molecule of zerumbone, a major component of Zingiber zerumbet. Concomitantly, however, we also observed numerous binding proteins when cells were exposed to this phytochemical. Thus this study focused on the role(s) of non-specific protein binding in its bioactivities. Interestingly, zerumbone-induced proteo-stress up-regulated the expressions of molecular chaperones and increased autophagy for degradation of abnormal proteins. This is the first study that showed phytochemical-induced proteo-stress has significant and unique roles in their bioactivities.
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