| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
The metabolic syndrome is a cluster of metabolic disorders that contribute to increased cardiovascular morbidity and mortality. Especially, nonalcoholic fatty liver disease (NAFLD) is emerging as the most common liver disease in metabolic syndrome. We found that the dietary intake of n-3 PUFA, n-3 polor lipid, extracts from plants alleviate NAFLD in obese, diabetic db/db mice. Our study demonstrated that those functional food components display at least two different physiological actions that alleviate NAFLD: one through the reduction of inflammatory damage by its suppression in MCP-1 production and the other through an increase of the serum adiponectin level and the prevention of visceral fat accumulation.
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