Identification of food components which regulate expression of genes related to metabolic syndrome
Project/Area Number |
23580173
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Food science
|
Research Institution | Saga University |
Principal Investigator |
NAGAO Koji 佐賀大学, 農学部, 教授 (10336109)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 脂肪組織 / 疾患遺伝子 / 食環境 / 生活習慣病 / 肥満誘発性病態 / アディポサイトカイン / 食事成分 / 抗炎症性 |
Research Abstract |
The metabolic syndrome is a cluster of metabolic disorders that contribute to increased cardiovascular morbidity and mortality. Especially, nonalcoholic fatty liver disease (NAFLD) is emerging as the most common liver disease in metabolic syndrome. We found that the dietary intake of n-3 PUFA, n-3 polor lipid, extracts from plants alleviate NAFLD in obese, diabetic db/db mice. Our study demonstrated that those functional food components display at least two different physiological actions that alleviate NAFLD: one through the reduction of inflammatory damage by its suppression in MCP-1 production and the other through an increase of the serum adiponectin level and the prevention of visceral fat accumulation.
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Report
(4 results)
Research Products
(95 results)
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[Journal Article] Structural Determination of Glucosylceramides in the Distillation Remnants of Shochu, the Japanese Traditional Liquor, and Its Production by Aspergillus kawachii2012
Author(s)
M. Hirata, T. Tsuge, L. Jayakody, Y. Urano, K. Takahashi, K. Sawada, S. Inaba, K. Nagao, H. Kitagaki
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Journal Title
J. Agrc. Food Chem
Volume: 60
Pages: 11473-11482
Related Report
Peer Reviewed
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[Journal Article] Structural Determination of Glucosylceramides in the Distillation Remnants of Shochu, the Japanese Traditional Liquor, and Its Production by Aspergillus kawachii.2012
Author(s)
M. Hirata, T. Tsuge, L. Jayakody, Y. Urano, K. Takahashi, K. Sawada, S. Inaba, K. Nagao, H. Kitagaki
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Journal Title
J. Agrc. Food Chem.
Volume: 60
Issue: 46
Pages: 11473-11482
DOI
Related Report
Peer Reviewed
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[Journal Article] Effect of Vaccinium ashei reade Leaf Extracts on Lipid Metabolism in Obese OLETF Rats2011
Author(s)
N. Inoue, K. Nagao, S. Nomura, B. Shirouchi, M. Inafuku, H. hirabaru, N. Nakahara, S. Nishizono, T. Tanaka, T. Yanagita
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 75
Issue: 12
Pages: 2304-2308
DOI
NAID
ISSN
0916-8451, 1347-6947
Related Report
Peer Reviewed
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[Journal Article] Screening of soy protein-derived hypotriglyceridemic di-peptides in vitro and in vivo.2011
Author(s)
N. Inoue, K. Nagao, K. Sakata, N. Yamano, PER. Gunawardena, SY Han, T. Matsui, T. Nakamori, H. Furuta, K. Takamatsu, T. Yanagita
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Journal Title
Lipids Health Dis.
Volume: 10
Issue: 1
Pages: 1-10
DOI
Related Report
Peer Reviewed
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