| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Research Abstract |
The results demonstrate that ovotransferrin (OTf) binds different insoluble sulfa antibiotics and for complex in which these hydrophobic antibiotics become totally water soluble. The antibiotics-off complexes showed potent antimicrobial activity against several pathogens or either Gram-positive or Gram-negative strains. Strikingly, the complexes were able to reach and kill pathogens intracellularly infecting human colon cells (HCT-116), and the mechanism was found to be mediated through endocytosis via transferring receptor found at the surface of human cells. The finding herald a fascinating opportunity with potential application of OTf as drug carrier for the treatment of infectious diseases.
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