| Project/Area Number |
23580178
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Aomori University of Health and Welfare |
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Principal Investigator |
IWAI KUNIHISA 青森県立保健大学, 健康科学部, 教授 (80404812)
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| Co-Investigator(Kenkyū-buntansha) |
MORINAGA Yae 山口大学, 教育学部, 講師 (40404818)
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| Research Collaborator |
NISHIJIMA Tomohiko グリコ乳業株式会社
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | フラボノイド / ペクチン / 吸収 / 構造活性相関 / 抗酸化作用 / 代謝 / ポリフェノール |
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| Research Abstract |
It is well known that flavonoids have various health promoting effects such as antioxidant activity, however their absorption is low. In this research we investigated the enhancing effect of pectin on the absorption of flavonoids and its effect on physiological activities of flavonoids in rats. Consequently, we found that the number of hydroxyl groups in B-ring and the existence of the carbonyl group in C-ring of flavonoids contributed strongly to the enhancing effect of pectin on flavonoid absorption. Moreover, the absorption of quercetin in rats increased with dose depending on pectin intake, and the antioxidant activity of low density lipoprotein in rats became strong with an increase of quercetin absorption.
Pectin is well known to inhibit the absorption of nutrients such as cholesterol and lipids. However, these results show the possibility that pectin has a new physiological function, and this approach is beneficial for improvement of low absorption of flavonoids.
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