Elucidation of molecular mechanisms underlying the intestinal symbiotic system and application to prevention of inflammatory diseases
| Project/Area Number |
23580186
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HOSONO Akira 日本大学, 生物資源科学部, 准教授 (70328706)
KAMINOGAWA Shuichi 日本大学, 生物資源科学部, 教授 (50011945)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 食品機能 / 共生 / 腸内細菌 / 腸管上皮細胞 / マスト細胞 / 遺伝子発現 |
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| Research Abstract |
Molecular mechanisms underlying the intestinal symbiosis was analyzed. It was shown that intestinal bacteria are involved in the establishment and maintenance of the symbiosis by changing specific gene expression in intestinal epithelial cells and mast cells of the host through, at least in part, epigenetic mechanisms including DNA methylation and miRNA expression. The results are applicable to the evaluation system for food components which regulate inflammatory reactions and thereby keep healthy symbiotic system in the intestine.
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Report
(4 results)
Research Products
(89 results)
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[Journal Article] IgA production in the large intestine is modulated by a different mechanism than in the small intestine : Bacteroides acidifaciens promotes IgA production in the large intestine by inducing germinal center formation and increasing the number of IgA^+ B cells2013
Author(s)
Yanagibashi T, Hosono A, Oyama A, Tsuda M, Suzuki A, Hachimura S, Takahashi Y, Momose Y, Itoh K, Hirayama K, Takahashi K, Kaminogawa S.
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Journal Title
Immunobiol
Volume: 218
Pages: 645-651
Related Report
Peer Reviewed
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[Journal Article] IgA production in the large intestine is modulated by a different mechanism than in the small intestine: Bacteroides acidifaciens promotes IgA production in the large intestine by inducing germinal center formation and increasing the number of IgA+ B cells.2013
Author(s)
Tsutomu Yanagibashia, Akira Hosono, Akihito Oyama, Masato Tsuda, Ami Suzuki, Satoshi Hachimura, Yoshimasa Takahashi, Yoshika Momose, Kikuji Itoh, Kazuhiro Hirayama, Kyoko Takahashi, Shuichi Kaminogawa
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Journal Title
Immunobiology
Volume: 218
Issue: 4
Pages: 645-651
DOI
Related Report
Peer Reviewed
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