Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Research Abstract |
Increase endogenous GLP-1 secretion from intestinal L cells by food factors is one of the crucial targets for prevention and treatment of diabetes. In the present study, we demonstrate that curcumin, a yellow pigment, significantly increases GLP-1 secretion in L cells model, and we clarified the structure activity relationship using curcumin derivatives. Also, concerning the secretory mechanism, the significant increase in GLP-1 secretion by curcumin involved the CaMKII pathway, and was independent of extracellular signal-regulated kinase, PKC, and the cAMP/PKA-related pathway.
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