Mass production of 15N labeled DNJ to evaluate the absorption and excretion of 1-deoxynojirimycin
| Project/Area Number |
23580190
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | National Agriculture and Food Research Organization |
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Principal Investigator |
KIMURA Toshiyuki 独立行政法人農業・食品産業技術総合研究機構, 中央農業総合研究センター生産体系研究領域, 主任研究員 (70355303)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Kiyotaka 東北大学, 大学院農学研究科, 准教授 (80361145)
MIYAZAWA Teruo 東北大学, 大学院農学研究科, 教授 (20157639)
YAMAGISHI Kenji 独立行政法人農業・食品産業技術総合研究機構, 東北農業研究センター環境保全型農業研究領域, 主任研究員 (80355304)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 吸収・動態 / １－デオキシノジリマイシン / DNJ / ラベル化 / 発酵生産 / 安定同位体ラベル / 安全性 / 吸収・代謝 |
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| Research Abstract |
Mulberry leaves have the unique ingredient called 1-deoxynojirimycin which suppresses the postprandial blood glucose, so that are considered as the food materials which are expected to prevent diabetes. Sufficient safety assessment of DNJ is necessary to be widely accepted as the functional food material in the market. In this research, we tried to clarify the absorption, distribution, metabolism and excretion of DNJ. We established the mass production method of DNJ by using fermentation technique, followed by succeed to produce 10g of the purified 15N labeled DNJ. We orally administrated the purified 15N labeled DNJ to rats, now studying the mechanism analysis and safety evaluation.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] 1-deoxynojirimycin attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells2014
Author(s)
E, S., Kijima, R., Honma, T., Yamamoto, K., Hatakeyama, Y., Kitano, Y., Kimura, T., Nakagawa, K., Miyazawa, T., Tsuduki, T.
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Journal Title
Exp. Gerontol.
Volume: 55C
Pages: 63-69
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Production of the α-glycosidase inhibitor 1-deoxynojirimycin from Bacillus species2013
Author(s)
Onose, S., Ikeda, R., Nakagawa, K., Kimura, T., Yamagishi, K., Higuchi, O., Miyazawa, T.
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Journal Title
Food Chem.
Volume: 138
Issue: 1
Pages: 516-523
DOI
Related Report
Peer Reviewed
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[Presentation] Effect of mulberry 1-deoxynojirimycin on postprandial glycemic control2012
Author(s)
Onose, S., Asai, A., Nakagawa, K., Kimura, T., Oikawa, S., Miyazawa, T.
Organizer
11th Maillard reaction symposium
Place of Presentation
Nancy, France
Related Report
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