Development of chiral ligand-exchange method using selector ligand and/or metal ion cocktails
| Project/Area Number |
23580192
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Tokai University (2013)
Toyama Institute of Health (2011-2012) |
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Principal Investigator |
KODAMA Shuji 東海大学, 理学部, 教授 (70360807)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Atsushi 中部大学, 応用生物学部, 教授 (60360806)
AIZAWA Sen-ichi 富山大学, 理工学研究部, 教授 (60231099)
TAGA Atsushi 近畿大学, 薬学部, 準教授 (20247951)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | キャピラリー電気泳動 / 配位子交換 / 光学分割 / α-ヒドロキシ酸 / ジュース / 光学異性体 / 有機酸 / 金属イオン |
|---|
| Research Abstract |
Using a singular ligand and a dual central ion in a background electrolyte, a ligand exchange CE was investigated for the simultaneous enantioseparation of malic, tartaric and isocitric acids. Tartaric acid was enantioseparated by a ligand exchange CE with 100 mM D-quinic acid as a singular ligand and 10 mM Cu(II) ion as a singular central ion, but malic and isocitric acids were not enantioseparated. Addition of 1.8 mM Sc(III) ion to the background electrolyte with 10 mM Cu(II) ion to create a dual central metal ion system permitted the simultaneous determination of these alpha-hydroxy acid enantiomers and citric acid. The proposed ligand exchange CE was thus well suited for detecting adulteration of fruit juices.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Determination ofα-hydroxy acids and their enantiomers in fruit juices by ligand exchange capillary electrophoresis with a dual central metal ion system2013
Author(s)
Kodama, S., Aizawa, S., Taga, A., Yamamoto, A., Honda, Y., Suzuki, K., T Kemmei, T., Hayakawa, K.
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Journal Title
Electrophoresis
Volume: 34
Pages: 1327-1333
Related Report
Peer Reviewed
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[Journal Article] Enantioseparation ofα-hydroxy acids by chiral ligand exchange CE with a dual central metal ion system2012
Author(s)
Kodama, S., Yamamoto, A., Aizawa, S., Honda, Y., Suzuki, K., Kemmei, T., Taga, A.
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Journal Title
Electrophoresis
Volume: 33
Pages: 2920-2924
Related Report
Peer Reviewed
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[Journal Article] Direct Enantioseparation of lipoic acid in dietary supplements by capillary electrophoresis using trimethyl-β-cyclo- dextrin as a chiral selector2012
Author(s)
Kodama, S., Taga, A., Aizawa, S., Kemmei, T., Honda, Y., Suzuki, K., Yamamoto, A.
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Journal Title
Electrophoresis
Volume: 33
Pages: 2441-2445
Related Report
Peer Reviewed
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[Journal Article] Simple determination of a strongly aromatic compound, sotolon, by capillary electrophoresis2012
Author(s)
Taga, A., Sato, A., Suzuki, K., Takeda, M., Kodama, S.
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Journal Title
J. Oleo Sci
Volume: 61
Pages: 45-48
NAID
Related Report
Peer Reviewed
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[Journal Article] Determination of ethylenediaminetetraacetic acid in sea water by solid-phase extraction and high-performance liquid chromato- graphy2012
Author(s)
Kemmei, T., Kodama, S., Fujishima, H., Yamamoto, A., Inoue, Y., Hayakawa, K.
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Journal Title
Analytica Chimica Acta
Volume: 709
Pages: 54-58
Related Report
Peer Reviewed
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[Journal Article] Development of a variable-wavelength optical rotation detector in the ultraviolet region2011
Author(s)
Yamamoto, A., Miwa, T., Kawai, M., Tadokoro, T., Tsutsumi, K., Sato, T., Kodama, S., Hayakawa, K.
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Journal Title
Anal. Sci
Volume: 27
Pages: 799-803
NAID
Related Report
Peer Reviewed
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