| Project/Area Number |
23580234
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Wood science
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| Research Institution | Tokyo University of Agriculture (2012-2013)
Takasaki University of Health and Welfare (2011) |
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Principal Investigator |
EGUCHI FUMIO 東京農業大学, 地域環境科学部, 教授 (60337467)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIMOTO Hiroaki DKラボラトリー (30516919)
MIYAZAWA Noriko 高崎健康福祉大学, 健康福祉学部, 助教 (20348147)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | きのこ / 生活習慣病 / 血小板凝集抑制 / ケモカイン遺伝子発現抑制 / 機能性食品 / 子実体 / 担子菌 / 微生物 / 脂質異常症 / 高血圧症 / ヒト試験 / 生理活性物質 / えのき氷 / 疾患モデル動物 / 多機能性 / ケモカイン遺伝子発言抑制 |
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| Research Abstract |
It has been shown that mushroom basidiocarp hot water extract suppresses platelet aggregation. Platelet aggrgation is caused by platelets binding to PAF receptors. The platelet aggregation suppression effect of many mushrooms not only promotes TXA2 through COX metabolism, both PLA2 and activity in the domain of regeneration of 1-alkyl phosphatidycholine, a cell membrane phospholipid, have also been confirmed. Also, suppression of ADP's production, which stems from the process passing from breakdown of vascular endothelials to dense granule platelet production, has been shown. Because mushroom are an active material in a wide range of platelet aggregation suppressive functions, regularly eating mushrooms is now known to contribute to improving the symptoms of vascular endothelial diseases by stimulating the blood vessels, neutrophil activation, and smooth muscle contraction, improving renal hypertension, and aiding other functions related to platelet aggregation.
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