Studies on molecluar mechanism of lipid droplet formation in telesot oocytes
| Project/Area Number |
23580242
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General fisheries
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| Research Institution | Hokkaido University |
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Principal Investigator |
TODO TAKASHI 北海道大学, 大学院水産科学研究院, 准教授 (60303111)
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| Co-Investigator(Renkei-kenkyūsha) |
HARA Akihiko 北海道大学, 名誉教授 (40091483)
HIRAMATSU Naoshi 北海道大学, 大学院水産科学研究院, 准教授 (10443920)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 卵形成 / 卵成長 / 卵母細胞 / 油球 / 脂質 / リポタンパク質 / 卵黄 / 水産学 / タンパク質 / 魚類 / 生理学 / 水差学 / 発生・分化 |
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| Research Abstract |
In teleost fishes, high amount of lipids and proteins are accumulated in oocytes during their growth phase; they are later utilized as energy and nutrient resources by developing embryos and larvae. However, little is known about the origin of such lipids and the mechanisms underlying their accumulation into oocytes. In the present study, we aimed to clarify the mechanisms at the molecular levels. As the results, we confirmed that, for the first time, plasma very low density lipoprotein is the major carrier of neutral lipid to oocyte lipid droplets, and updated the model for the oocyte lipidation.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Molecular cloning and partial characterization of an ovarian receptor with seven ligand repeats, an orthologue of low-density lipoprotein receptor, in the cutthroat trout (Oncorhynchus clarki)2013
Author(s)
Luo, W., Ito, Y., Mizuta, H., Massaki, K., Hiramatsu, N., Todo, T., Reading, B. J., Sullivan, C. V., Hara, A.
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Journal Title
Comparative Biochemistry and Physiology Part A
Volume: 166
Pages: 263-271
DOI
Related Report
Peer Reviewed
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[Journal Article] Ovarian expression and localization of a vitellogenin receptor with eight ligand binding repeats in the cutthroat trout (Oncorhynchus clarki)2013
Author(s)
Mizuta, H., Luo, W., Ito, Y., Mushirobira, Y., Todo, T., Hara, A., Reading, B. J., Sullivan, C. V., Hiramatsu, N.
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Journal Title
Comparative Biochemistry and Physiology, Part B
Volume: 166
Pages: 81-90
DOI
Related Report
Peer Reviewed
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[Presentation] Yolk formation in fish: Multiple vitellogenins and their receptors.2013
Author(s)
Hiramatsu, N., Mizuta, H., Luo, W., Nishimiya, O., Wu, Meiqin, Mushirobira, Y., Reading, B.J., Sullivan, C.V., Todo, T., Hara, A.
Organizer
Diversification in Inland Finfish Aquaculture II (DIFAII)
Place of Presentation
University of South Bohemia, Vodnany, Czech Republic
Related Report
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[Presentation] Ligand binding properties of ovarian lipoprotein receptors in the cutthroat trout (Oncorhynchus clarki).2013
Author(s)
Mushirobira, Y., Mizuta, H., Luo, W., Todo, T., Hara, A., Hiramatsu, N.
Organizer
The 10th International Meeting on Reproductive Biology of Aquatic Animals of the East China Sea
Place of Presentation
Jeju National University, Jeju, Korea
Related Report
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