A study on the mechanisms of appetite regulation in super salmon and its application for aquaculture
| Project/Area Number |
23580277
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
NAKANO TOSHIKI 東北大学, (連合)農学研究科(研究院), 助教 (10217797)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRAKAWA Hitoshi 東北大学, 大学院農学研究科, 准教授 (40206280)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 農林水産物 / 水産学 / 栄養学 / 組換え食品 / バイオテクノロジー / 生理学 / 国際情報交流（カナダ） / 国際情報交流 |
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| Research Abstract |
Growth in fish is regulated by the growth hormone (GH)-insulin-like growth factor (IGF) axis. Little is known concerning the in vivo levels of global metabolites and the mechanism of enhancement of growth in GH transgenic fish. The present study examined the charged metabolites levels in GH transgenic coho salmon (Oncorhynchus kisutch) by metabolomic analysis.The most notable difference found between transgenic and NT fish was that glycolysis metabolite levels changed in the muscle of transgenic fish. In addition, the change in some metabolite levels in the transgenic fish muscle was enhanced by ration-restriction. However, a few metabolites levels of the TCA cycle were found to decrease in the transgenic fish muscle. These effects observed in muscle were different from effects seen in liver. The results suggest that GH transgenesis can improve the use of carbohydrates as a source of energy associated with rapid growth.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Natural marine products inhibit formation of 8-chloroguanosine mediated by hypochlorous acid, myeloperoxidase and activated neutrophils2012
Author(s)
Nakano, T., Shiba, Y., Yamaguchi, T., Sato, M., Ohshima, H.
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Journal Title
Free Radic. Biol. Med.
Volume: 53 (suppl. 1)
Related Report
Peer Reviewed
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[Journal Article] Differences in heat shock-induced stress responses of temperate coho salmon Oncorhynchus kisutch and tropical rabbitfish Siganus guttatus2012
Author(s)
Nakano, T., Shoji, Y., Hayashi, S., Yamaguchi, T., Sato, M., Sugama, N., Takemura, A.
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Journal Title
Book of Abstract, Asia-Pacific Marine Biotechnology Conference (USB memory)
Volume: -
Related Report
Peer Reviewed
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[Journal Article] Heat shock-induced oxidative stress modulates growth-related gene expressions and redox status in coho salmon2011
Author(s)
Nakano, T., Kameda, M., Shoji, Y., Yamaguchi, T., Sato, M., Afonso, L., Devlin, R.H., Iwama, G.K.
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Journal Title
Comp. Physiol. Biochem.
Volume: 28(suppl.)
Pages: 142-142
Related Report
Peer Reviewed
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[Presentation] Metabolome profiling of growth hormone transgenic and non-transgenic fish. Seikagaku, 85, 122 (2013)2013
Author(s)
T. Nakano, H. Shirakawa, T. Yamaguchi, M. Sato, Y. Suda, M. Saito, H. Maki, T. Soga, G. Yeo, R.H. Devlin
Organizer
86^<th> Ann. Meet. Jap. Biochem. Soc
Place of Presentation
Pacifico Yokohama, Sep
Related Report
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[Presentation] Metabolome profiling of growth hormone transgenic and non-transgenic fish2013
Author(s)
Nakano, T., Shirakawa, H., Yamaguchi, T., Sato, M., Suda, Y., Saito, M., Maki, H., Soga, T., Yeo, G., Devlin, R.H.
Organizer
第86回日本生化学会
Place of Presentation
パシフィコ横浜（神奈川県横浜市）
Related Report
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[Presentation] Effect of moderate or severe acute stressor on expressions of growth-related genes in cultured fish2013
Author(s)
Nakano, T., Yamaguchi, T., Sato, M., Devlin, R.H.
Organizer
15th Colloque franco-japonais d'Oceanographie
Place of Presentation
La Presidence de Aix-Marseille Universite, Jardins du Pharo, Marseille, France
Related Report
Invited
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[Presentation] Differences in heat shock-induced stress responses of temperate coho salmon Oncorhynchus kisutch and tropical rabbitfish Siganus guttatus, Book of Asia-Pacific Marine Biotech. Conf., 16S2-12012
Author(s)
T. Nakano, Y. Shoji, S. Hayashi, T. Yamaguchi, M. Sato, N. Sugama, A. Takemura
Organizer
Asia-Pacific Marine Biotechnology Conference
Place of Presentation
Central Public Hall of Kochi City Culture Plaza, CUL-PORT, Kochi, Japan
Related Report
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[Presentation] Heat shock-induced oxidative stress modulates growth-related gene expressions and redox status in coho salmon, Book of Abstract (CD-ROM)2011
Author(s)
T. Nakano, Y. Shoji, S. Hayashi, T. Yamaguchi, M. Sato, L.O.B. Afonso, R.H. Devlin, G.K. Iwama
Organizer
International Conference of Comparative Physiology and Biochemistry
Place of Presentation
Nagoya Congress Center, Nagoya, Japan
Related Report
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