Distribution and function of tetrodotoxin-binding proteins in the pufferfish Takifugu rubripes -elucidation from a viewpoint of sexual maturation
| Project/Area Number |
23580282
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
ARAKAWA Osamu 長崎大学, 水産・環境科学総合研究科, 教授 (40232037)
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| Co-Investigator(Kenkyū-buntansha) |
TAKATANI Tomohiro 長崎大学, 水産・環境科学総合研究科, 教授 (90304972)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | テトロドトキシン / フグ / ツムギハゼ / テトロドトキシン結合性タンパク質（PSTBP） / 成熟 / トラフグ / 交雑フグ / 肝量指数（HSI） / 生殖腺体指数（GSI） / クサフグ / マフグ / PSTBP |
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| Research Abstract |
Various tetrodotoxin (TTX) administration experiments using non-toxic cultured pufferfish, and investigations on internal TTX distribution of several wild pufferfish species and the goby Yongeichthys criniger demonstrated that TTX kinetics inside the body changes depending on the skin/liver development due to growth, and ovary development/maturation due to sexual maturation in these TTX-bearing fish. Moreover, searches for homologous genes of the TTX-binding protein (PSTBP) on several pufferfish species indicated that Takifugu rubripes possesses 3 candidate genes, 2 of which actually exist as proteins in the blood plasma, and that the other 3 toxic species also have 2-domain type candidate genes, and the difference in their sugar chain binding sites may be related to the toxin accumulation ability.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Distribution of Toxicity in Liver of Wild Pufferfish <i>Takifugu rubripes</i>2013
Author(s)
谷口香織, 髙尾秀樹, 新名真也, 山中祐二, 岡田幸長, 中島梨花, 王 俊杰, 辰野竜平, 阪倉良孝, 高谷智裕, 荒川 修, 野口玉雄
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Journal Title
Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)
Volume: 54
Issue: 4
Pages: 277-281
DOI
NAID
ISSN
0015-6426, 1882-1006
Related Report
Peer Reviewed
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[Presentation] 天然トラフグ肝臓の毒性分布2013
Author(s)
谷口香織, 髙尾秀樹, 新名真也, 山中祐二, 岡田幸長, 中島梨花, 王 俊杰, 辰野竜平, 阪倉良孝, 高谷智裕, 荒川 修, 野口玉雄
Organizer
第106回日本食品衛生学会学術講演会
Place of Presentation
沖縄コンベンションセンター（沖縄県宜野湾市）
Related Report
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[Presentation] Transfer profiles of intramuscularly administered tetrodotoxin to artificial hybrid specimens of the pufferfish : Takifugu rubripes × Takifugu niphobles and T. niphobles × T. rubripes, Joint2012
Author(s)
Y. Yamanaka, S. Niina, J. Wang, T. Araki, R. Tatsuno, K. Ikeda, M. Hamasaki, Y. Sakakura, T. Takatani, O. Arakawa
Organizer
International Symposium on Marine Science and Technology
Place of Presentation
Jeju
Year and Date
2012-10-25
Related Report
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