Mechanism of degradation of paralytic shellfish toxin by polyphenols

Research Project

Project/Area Number	23580284
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Fisheries chemistry
Research Institution	Kitasato University
Principal Investigator	SATO Shigeru 北里大学, 海洋生命科学部, 准教授 (20170748)
Project Period (FY)	2011 – 2013
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000) Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	麻痺性貝毒 / ポリフェノール / 酸化還元電位 / 酸化分解 / 没食子酸 / 分解 / ネオサキシトキシン / デカルバモイルサキシトキシン / 茶カテキン / プリン
Research Abstract	Polyphenols (PPs) such as gallic acid and its derivatives in wine and tea were revealed to decompose 11-reduced paralytic shellfish toxins (PST). It was reported that incubation of PST with strong oxidants in such as hydro peroxide in basic solution gives fluorescent purines. A same purine derivative was found in the reaction mixture of PPs and PST after mild incubation in neutral aquatic solution. Addition of PPs to neutral phosphate buffer reduced oxidation-reduction potential of the solution, and enhanced the oxidation-degradation of PST. These findings indicate that oxidized PPs react with PST, or PPs act as effective catalysts to oxidize PST by dissolved oxygen.