Verification of the determinants of production ability and the artificial control of the IGF-1 related to the future lactation and reproduction in female calf
| Project/Area Number |
23580363
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Zootechnical science/Grassland science
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIDA Katsuya 帯広畜産大学, 畜産学部, 教授 (70419216)
SHIMIZU Takashi 帯広畜産大学, 畜産学部, 准教授 (90375113)
SHIRASUNA Koumei 自治医科大学, 医学部, 助教 (20552780)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 乳用牛 / 一塩基多型 / IGF-1 / GH受容体 / 繁殖 / 代謝 |
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| Research Abstract |
The aim of the present study was to investigate the effect of genotype and/or feeding management on the ability of insulin-like growth factor-I (IGF-1) production related to milk production and reproductive function in dairy cows.
For genotype, we confirmed the relationship between one of the single nucleotide polymorphisms (SNP) of growth hormone receptor (GHR) and the increasing rate of blood IGF-1 level after hormonal injection. In addition, GHR-SNP type was related to milk yield and energy status after first calving. On the other hand, for feeding management, the supply of the intensive milk replacer for calves induced higher blood IGF-1 level; however, the increasing rate of blood IGF-1 level after hormonal injection did not differ between intensive and conventional milk replacer. Overall, our study showed that the ability of IGF-1 production was influenced by GHR-SNP in dairy cows.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Oestradiol enhances plasma growth hormone and insulin-like growth factor-I concentrations and increase the expression of their receptors mRNAs in the liver of ovariectomized cows2011
Author(s)
Çolak M, Shimizu T, Matsunaga N, Murayama C, Nagashima S, Kataoka M, Kawashima C, Matsui M, Van Dorland HA, Bruckmaier RM, Miyamoto A.
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Journal Title
Reprod Dom Anim
Volume: 46(5)
Pages: 854-861
Related Report
Peer Reviewed
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