| Project/Area Number |
23580365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Zootechnical science/Grassland science
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| Research Institution | Utsunomiya University |
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Principal Investigator |
AOYAMA Masato 宇都宮大学, 農学部, 准教授 (90282384)
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| Co-Investigator(Kenkyū-buntansha) |
SUGITA Shoei 宇都宮大学, 農学部, 教授 (50154472)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 動揺病 / 悪心 / ヤギ / 輸送ストレス / シスプラチン / 嘔吐 / 反芻動物 / ジフェンヒドラミン / 家畜 / 脳幹 |
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| Outline of Final Research Achievements |
This study investigates the existence of motion sickness, in other word, the sense of nausea, in goats. In the first experiment, the effect of the load transportation on the c-Fos protein (as a marker for the activation of the neurons) expression in the caprine brain stem was examined. Transportation increased the number of c-Fos reactive neurons in the nucleus solitary tract (NST), which is involved in the nausea and emesis in other animals. In the second experiment, the effects of administration of cisplatin (CisP: one of the anti-cancer drugs but induce strong nausea and emesis in humans and dogs) on goats were examined. The administration of CisP induced the ‘specific lying posture’, which defined as the lowered head and little movements. This behavioral response was accompanied by the remarkable increase in blood cortisol level, which indicates the strong stress. These results indicate that goats might experience nausea when they were transported or administrated with CisP.
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