Characterization of a novel lipoprotein receptor (LRP12) in chicken liver –The basic knowledge for lipid metabolism -

• Project/Area Number: 23580385
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied animal science
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: KAN Sato 東京農工大学, (連合)農学研究科(研究院), 准教授 (20250730)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: ニワトリ / 肝臓 / リポ蛋白 / 脂質代謝 / 鶏

Research Abstract

In present study, the function of LDL receptor related protein 12 (LRP12), a novel lipoprotein receptor in chickens, was characterized, and it is possible to utilize as the improvement in efficiency of the egg and meat production in chickens. LRP12 gene expression was high in liver of laying hens. Chicken LRP12 is the molecule for the uptake of LDL into cells, and it is a master regulator of lipoprotein uptake in chicken liver. In addition, LRP12 is characterized that the gene expression and lipoprotein uptake were no changed by the intracellular cholesterol concentrations of cells, and it plays the important role for the lipid recycling of liver-blood lipid-liver in chickens.

Research Products

• [Journal Article] Characterization of the expression profiles of adipogenesis-related factors, ZNF423, KLFs and FGF10, during preadipocyte differentiation and abdominal adipose tissue development in chickens. (2013)
  • Author(s): Matsubara ,Y., Aoki, M., Endo, T., Sato, K.
  • Journal Title: Comp Biochem Physiol A. Volume: 165 Issue: 3 Pages: 189-195
  • DOI: 10.1016/j.cbpb.2013.04.002
  • Peer Reviewed
• [Journal Article] Administration of insulin to newly hatched chicks improves growth performance via impairment of MyoD gene expression and enhancement of cell proliferation in chicken myoblasts (2012)
  • Author(s): Sato, K., Aoki, M., Kondo, R., Matsushita, K., Akiba, Y., Kamada, T.
  • Journal Title: Gen Comp Endocrinol Volume: 175 Issue: 3 Pages: 457-463
  • DOI: 10.1016/j.ygcen.2011.11.043
  • Peer Reviewed
• [Journal Article] dministration of insulin to newly hatched chicks improves growth performance via impairment of MyoD gene expression and enhancement of cell proliferation in chicken myoblasts. (2012)
  • Author(s): Sato, K., Aoki, M., Kondo, R., Matsushita, K., Akiba, Y., Kamada, T.
  • Journal Title: Gen Comp Endocrinol. Volume: 175 Pages: 457-463
  • Peer Reviewed
• [Journal Article] Regulation of bile acid, cholesterol and fatty acid synthesis in chicken primary hepatocytes by different concentrations of T0901317, an agonist of Liver X receptors (2011)
  • Author(s): Sato, K., Kamada, T.
  • Journal Title: Comp Biochem Physiol A Volume: 158 Issue: 2 Pages: 201-206
  • DOI: 10.1016/j.cbpa.2010.10.028
  • Peer Reviewed
• [Journal Article] Regulation of bile acid, cholesterol and fatty acid synthesis in chicken primary hepatocytes by different concentrations of T0901317, an agonist of Liver X receptors. (2011)
  • Author(s): Sato, K, Kamada, T.
  • Journal Title: Comp Biochem Physiol A. Volume: 158 Pages: 201-206
  • Peer Reviewed