| Project/Area Number |
23580386
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied animal science
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Takahisa 新潟大学, 農学部, 教授 (40253207)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 家禽 / 脚弱 / 破卵 / ビタミンD / 代謝 / ニワトリ / 1α水酸化酵素 / カルシウム代謝 / １α水酸化酵素 / ビタミンＤ代謝 / 遺伝子 |
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| Research Abstract |
A large amount of economic loss is produced by several disorders related with calcium metabolism, the leg weakness and eggshell thinning, in the poultry industry. These disorders have been considered as a consequence of the disruption of vitamin D metabolism. In general, the biologically active form (1a,25-(OH)2D3) is converted from vitamin D3 via a two-step hydroxylation process catalyzed by 25-hydroxylase in the liver and 1a-hydroxylase in the kidney.
In this research project, the mRNA expression of 1a-hydroxylase was indicated in the extra-renal vitamin D-target tissues such as intestines and eggshell gland. The expression was also stimulated by estrogen, and inhibited with aging. These results suggested that 1a,25-(OH)2D3 is locally synthesized from 25-hydroxycholecalciferol (25-(OH)D3) in target-tissues, and directly regulates calcium metabolism. Here, we furthermore suggested that 25-(OH)D3 supplement improves eggshell quality by modification of local vitamin D metabolism.
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