Studies on the development of feedback mechanisms of the pituitary-thyroid axis of the chick embryo

• Project/Area Number: 23580387
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied animal science
• Research Institution: Gifu University
• Principal Investigator: IWASAWA ATSUSHI 岐阜大学, 応用生物科学部, 教授 (90242742)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2013: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
• Keywords: 代謝・内分泌制御 / ニワトリ / 甲状腺刺激ホルモン / 甲状腺ホルモン

Research Abstract

The hypothalamus-pituitary-thyroid axis is one of the important homeostatic regulatory systems of higher vertebrates. This research was undertaken using chick embryos for the purpose of clarifying at what stages of their development the components of this axis emerge and start functioning. The results obtained suggested that in the peripheral organs from before day 12 of incubation regulation by small amounts of circulating thyroid hormones and peripheral deiodinases were functioning according to the demand of each developing organ, and that top-down regulation by thyrotropin released from the pituitary played an important role around hatching when large amounts of circulating thyroid hormones were necessary.

Research Products

• [Journal Article] 鶏胚の血中甲状腺ホルモンの変動と肝臓における脱ヨード酵素およびトランスサイレチンの意義 (2013)
  • Author(s): 柴田光浩,Too H.C.,岩澤淳,Darras V.
  • Journal Title: 東海畜産学会報 Volume: 24 Pages: 15-15
  • URL: http://www.tokaichikusan.org/Journal.html
• [Journal Article] Ontogenic Profile of Hexokinase and Glucokinase mRNA Expressions in Embryonic Chicken Liver and Muscle (2013)
  • Author(s): Roy T.K., Iwasawa A., Shimizu Y., Kageyama K., Yoshizaki N.
  • Journal Title: The Journal of Poultry Science Volume: 50 Issue: 3 Pages: 270-274
  • DOI: 10.2141/jpsa.0120156
  • NAID: 10031189335
  • ISSN: 1346-7395, 1349-0486
  • Peer Reviewed
• [Journal Article] Ontogenic Profile of Gluconeogenic Key Enzyme Gene Expressions in Embryonic Chicken Liver and Muscle (2013)
  • Author(s): Roy T.K., Iwasawa A., Shimizu Y., Kageyama K., Yoshizaki N.
  • Journal Title: The Journal of Poultry Science Volume: 50 Issue: 4 Pages: 381-387
  • DOI: 10.2141/jpsa.0120183
  • NAID: 130004446411
  • ISSN: 1346-7395, 1349-0486
  • Peer Reviewed
• [Presentation] 鶏胚の血中甲状腺ホルモンの変動と肝臓における脱ヨード酵素およびトランスサイレチンの意義 (2013)
  • Author(s): 柴田光浩,Too H.C.,岩澤淳,Darras V.
  • Organizer: 東海畜産学会平成25年度秋季大会
  • Place of Presentation: 日愛知県産業労働センターWINCあいち
  • Year and Date: 2013-12-06
• [Presentation] ニワトリ胚の発生過程における甲状腺ホルモンの脱ヨード酵素の働き (2013)
  • Author(s): 柴田光浩,Too H.C., Darras V.,岩澤淳
  • Organizer: 日本動物学会第84回岡山大会
  • Place of Presentation: 岡山大学津島キャンパス
  • Year and Date: 2013-09-28
• [Presentation] ニワトリの発生過程における甲状腺ホルモンの脱ヨード酵素の働き (2013)
  • Author(s): 柴田光浩,Too H.C.,岩澤淳,Darras V.
  • Organizer: 日本家禽学会2013年度秋季大会
  • Place of Presentation: 新潟大学五十嵐キャンパス
  • Year and Date: 2013-09-08
• [Presentation] ニワトリ胚の発生過程における甲状腺ホルモンの脱ヨード酵素の働き (2013)
  • Author(s): 柴田光浩，H.C.Too，岩澤 淳，V.Darras
  • Organizer: 日本家禽学会２０１３年度秋季大会
  • Place of Presentation: 新潟大学五十嵐キャンパス
• [Presentation] ニワトリ胚の発生過程における甲状腺ホルモンの脱ヨード酵素の働き (2012)
  • Author(s): 柴田光浩,Too H.C.,岩澤淳
  • Organizer: 日本動物学会中部支部大会
  • Place of Presentation: 松本市みやま荘
• [Presentation] ニワトリ胚の発生過程における甲状腺ホルモンの脱ヨード酵素の働き (2012)
  • Author(s): 岩澤 淳
  • Organizer: 日本動物学会中部支部大会
  • Place of Presentation: みやま荘（松本市）