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Cooperative and antagonistic interaction between progesterone and eicosanoid in the ovary

Research Project

Project/Area Number 23580392
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied animal science
Research InstitutionKitasato University

Principal Investigator

KURUSU Shiro  北里大学, 獣医学部, 准教授 (50215076)

Co-Investigator(Kenkyū-buntansha) ORINO Koichi  北里大学, 獣医学部, 准教授 (60214235)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords卵巣 / ステロイド / エイコサノイド / 排卵 / 黄体退行 / ホスホリパーゼ / シクロオキシゲナーゼ / オートタキシン / 妊娠 / 分娩 / リン脂質代謝
Research Abstract

Our findings are as follows. 1) COX-2 induction by the preovulatory mature follicles could be regulated by a crosstalk with the metabolism of steroid including P4 and by a feedforward/feedback mechanism involving GIVA PLA2 metabolites. 2) PGE synthase in the granulosa layers remains undefined. 3) In naturally regressing CL of cycling rats, autotoxin was identified to be a novel factor that was induced and contributed to tissue remodeling via function downstream of GIVA PLA2. 4) This protein was also induced in CL of pregnancy and supposed to have distinct roles in CL regulation. With this fact and the nature of Fas expression, there is a fundamental difference among CL of pregnancy, pseudopegnancy, and the cycling.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (18 results)

All 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (14 results) (of which Invited: 1 results) Remarks (1 results)

  • [Journal Article] Autotaxin as a novel, tissue-remodeling-related factor in regressing corpora lutea of cycling rats2013

    • Author(s)
      Masuda K, Haruta S, Orino K, Kawaminami M, Kurusu S.
    • Journal Title

      FEBS Journal

      Volume: 280(24) Issue: 24 Pages: 6600-6612

    • DOI

      10.1111/febs.12565

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] A comprehensive immunohistochemistry of prostaglandins F2α and E2 synthetic enzymes in rat ovary and uterus around parturition.2013

    • Author(s)
      Satoh H, Watanabe K, Kawaminami M, Kurusu S.
    • Journal Title

      Prostaglandins Other Lipid Mediators

      Volume: 106 Pages: 23-28

    • DOI

      10.1016/j.prostaglandins.2013.07.005

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Group IVA phospholipase A2 optimizes ovulation and fertilization in rodents through induction of and metabolic coupling with prostaglandin endoperoxide synthase 2.2012

    • Author(s)
      Kurusu S, Sapirstein A, Bonventre JV.
    • Journal Title

      FASEB Journal

      Volume: 26(9) Issue: 9 Pages: 3800-3810

    • DOI

      10.1096/fj.12-203968

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Autotaxin as a novel, tissue remodeling-associated factor in regressing corpora lutea of cycling rats2013

    • Author(s)
      Kurusu S, Masuda K, Haruta S, Kawaminami M.
    • Organizer
      GEM/GERLI Lipidomics Meeting
    • Place of Presentation
      Saint-Jean-Cap-Ferrat, France
    • Year and Date
      2013-11-12
    • Related Report
      2013 Final Research Report
  • [Presentation] 妊娠ラットの生殖組織におけるAutotaxinの発現と活性2013

    • Author(s)
      白坂美貴、戸田素弘、増田加奈子、治田悟、寺島涼太、米澤智洋、久留主志朗、汾陽光盛
    • Organizer
      第156回日本獣医学会岐阜
    • Place of Presentation
      岐阜県
    • Year and Date
      2013-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Group IVA PLA2 cooperates with cyclooxygenase- 2 to optimize ovulation and fertilization in rodents2012

    • Author(s)
      Kurusu S, Sapirstein A, Bonventre JV.
    • Organizer
      OVARIAN CLUB II
    • Place of Presentation
      Prague, Czech
    • Year and Date
      2012-11-09
    • Related Report
      2013 Final Research Report
  • [Presentation] ラットの黄体退行におけるFas及び関連因子の発現と局在2012

    • Author(s)
      吉尾啓、佐藤弘法、米澤智洋、久留主志朗、汾陽光盛
    • Organizer
      盛岡
    • Place of Presentation
      岩手県
    • Year and Date
      2012-09-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of group IVA phospholipase A2 in testosterone biosynthesis and male reproductive function in rodents2012

    • Author(s)
      Kurusu S, Sapirstein A, Kawaminami M, Bonventre JV.
    • Organizer
      the Faseb summer conference
    • Place of Presentation
      Vermont USA
    • Year and Date
      2012-07-19
    • Related Report
      2013 Final Research Report
  • [Presentation] げっ歯類の雄性生殖におけるGroup IVA phospholipase A2の役割2012

    • Author(s)
      久留主志朗、澤田治美、汾陽光盛
    • Organizer
      第54回日本脂質生化学会福岡
    • Place of Presentation
      福岡県
    • Year and Date
      2012-06-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Group IVA phospholipase A2 cooperates with cyclooxygenase-2 to optimize ovulation and fertilization in rodents.2012

    • Author(s)
      Shiro Kurusu, Adam Sapirstein, Joseph Bonventre.
    • Organizer
      The Ovarian Club II
    • Place of Presentation
      Pragh, Czech
    • Related Report
      2012 Research-status Report
  • [Presentation] Role of group IVA phospholipase A2 in testosterone biosynthesis and male reproductive system in rodents2012

    • Author(s)
      Shiro Kurusu, Adam Sapirstein, Harumi Sawada, Mitsumori Kawaminami, Joseph Bonventre.
    • Organizer
      FASEB summer research conference "Phospholipid metabolism: disease, signal transduction, and membrane dynamics"
    • Place of Presentation
      Vermont, USA
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] げっ歯類の雄性生殖におけるGroup IVA phospholipase A2の役割2012

    • Author(s)
      久留主志朗・澤田治美・汾陽光盛
    • Organizer
      第54回日本脂質生化学会
    • Place of Presentation
      九州大学、福岡市
    • Related Report
      2012 Research-status Report
  • [Presentation] ラットの黄体退行におけるFas及び関連因子の発現と局在2012

    • Author(s)
      吉尾啓・佐藤弘法・米澤智洋・久留主志朗・汾陽光盛
    • Organizer
      第154回日本獣医学会
    • Place of Presentation
      岩手大学、盛岡市
    • Related Report
      2012 Research-status Report
  • [Presentation] Group IVA phospholipase A2 regulates hCG-induced cyclooxygenase-2 expression in rodent preovulatory follicles2011

    • Author(s)
      Kurusu S, Sapirstein A, Bonventre JV.
    • Organizer
      第104回日本繁殖生物学会盛岡
    • Place of Presentation
      岩手県
    • Year and Date
      2011-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Group IVA phospholiapse A2による排卵時のcyclooxygenase-2の誘導の調節2011

    • Author(s)
      久留主志朗、Adam Sapirstein, Joseph Bonventre
    • Organizer
      第104回日本繁殖生物学会
    • Place of Presentation
      いわて県民情報交流センター・アイーナ(盛岡市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Autotaxin as a novel, tissue remodeling-associated factor in regressing corpora lutea of cycling rats.

    • Author(s)
      Kurusu S, Masuda K, Haruta S, Kawaminami M
    • Organizer
      GEM/GERLI Lipidomics Meeting
    • Place of Presentation
      Saint-Jean-Cap-Ferrat, France
    • Related Report
      2013 Annual Research Report
  • [Presentation] 妊娠ラットの生殖組織におけるAutotaxinの発現と活性

    • Author(s)
      白坂美貴, 戸田素弘, 増田加奈子, 治田 悟, 寺島涼太, 米澤智洋, 久留主志朗, 汾陽光盛
    • Organizer
      第156回日本獣医学会
    • Place of Presentation
      岐阜大学、岐阜
    • Related Report
      2013 Annual Research Report
  • [Remarks] 獣医学科獣医生理学教室

    • URL

      http://www.kitasato-u.ac.jp/vmas/faculty/vm/vm_study02.html

    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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