| Project/Area Number |
23580402
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OISHI Shinya 京都大学, 大学院薬学研究科, 講師 (80381739)
ISHII Hirotaka 日本医科大学, 医学部, 講師 (20445810)
SUWA Makiko 独立行政法人産業技術総合研究所, 生命情報 工学研究センター, 主幹研究員 (30242241)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 神経ペプチド / GnRH / GPCR / LH / ラット / 性腺刺激ホルモン放出ホル モン / G蛋白質共役型受容体 / 性腺刺激ホルモン放出ホルモン |
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| Research Abstract |
Transcriptome analysis with Sevens, a database of G-protein coupled receptors (GPCR), showed the expression profiles of GPCR in gonadotropin-releasing hormone (GnRH) neurons obtained from GnRH-green fluorescent protein transgenic mice. Among those GPCR, kisspeptin receptor GPR54 is considered as a key molecule controlling GnRH secretion. This study also showed brain region specific enhancer of Kiss1 gene and histone acetylation and chromatin loop formation are responsible for Kiss1 gene up-regulation.
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