Clarification of the natural host defense system against indigenous bacteria in alimentary tract
Project/Area Number |
23580403
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Basic veterinary science/Basic zootechnical science
|
Research Institution | Kobe University |
Principal Investigator |
KITAGAWA Hiroshi 神戸大学, 自然科学系先端融合研究環, 教授 (40125307)
|
Co-Investigator(Kenkyū-buntansha) |
KAWANO Junichi 神戸大学, (連合)農学研究科(研究院), 教授 (40127361)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 生体防御機構 / 消化管 / 常在細菌 / 自然免疫 / Toll-like receptor / 免疫組織化学 / 国際情報交流 |
Research Abstract |
The research achievements on the natural host defense against indigenous bacteria (IB) in animals is as follows: the clarification of the relationship between IB settlement and membranous Toll-like receptor (mTLRs)/secretory TLRs (sTLRs) in small and large intestines, the clarification of the relationship between the alternation of IB settlement and the bactericidal substance secretion in small intestine, the clarification of the peculiar epithelial differentiation in the follicle-associated intestinal crypts of gut-associated lymphatic tissue, the clarification of the detailed host defense with epithelial apoptosis against IB hyperproliferation in esophagus and epidermis, the demonstration of the direct transportation of chylomicrons from the intestinal epithelium into the hepatic portal blood and the endothelial receptor for chylomicron transportation, the clarification of the recognition system with mTLRs and secretion of sTLRs against IB in the respiratory tract.
|
Report
(4 results)
Research Products
(50 results)
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[Journal Article] Ultrastructural and histochemical study on the epithelial differentiation to Paneth cells in the rat ascending colon2014
Author(s)
Mantani, Y., Nishida, M., Yuasa, H., Yamamoto, K., Takahara, E., Omotehara, T., Udayanga, K. G. S., Kawano, J., Yokoyama, T., Hoshi, N. and Kitagawa, H.
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Journal Title
Anatomical Record
Volume: (accepted)
Issue: 8
Pages: 1462-1471
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Peculiar Composition of Epithelial Cells in Follicle-Associated Intestinal Crypts of Peyer’s Patches in the Rat Small Intestine2014
Author(s)
Mantani, Y., Yuasa, H., Nishida, M., Takahara, E., Omotehara, T., Udayanga, K. G. S., Kawano, J., Yokoyama, T., Hoshi, N. and Kitagawa, H.
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Journal Title
Journal of Veterinary Medical Science
Volume: 76
Issue: 6
Pages: 833-838
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed
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[Journal Article] Ultrastructural Demonstration of the Absorption and Transportation of Minute Chylomicrons by Subepithelial Blood Capillaries in Rat Jejunal Villi2013
Author(s)
Takahara, E., Mantani, Y., Udayanga, K. G. S., Qi, W.-M., Tanida, T., Takeuchi T., Yokoyama, T., Hoshi, N. and Kitagawa, H.
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Journal Title
Journal of Veterinary Medical Science
Volume: 75
Issue: 12
Pages: 1563-1569
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed
-
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[Journal Article] Histoplanimetrical Study on the Relationship between Invasion of Indigenous Bacteria into Intestinal Crypts and Proliferation of Epithelial Cells in Rat Ascending Colon2013
Author(s)
Mantani, Y., Takahara, E., Takeuchi, T., Kawano, J., Yokoyama, T., Hoshi, N., Kitagawa, H.
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Journal Title
The Journal of Veterinary Medical Science
Volume: 75
NAID
Related Report
Peer Reviewed
-
-
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[Journal Article] Alteration in the apoptosis process of rat esophageal epithelium with hyperproliferation of indigenous bacteria un a physiological condition2012
Author(s)
Udayanga, K. G. S., Yamamoto, K., Miyata, H., Yokoo, Y., Mantani, Y., Takahara, E., Qi, W.-M., Kawano, J., Yokoyama, T., Hoshi, N., Kitagawa, H.
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Journal Title
The Journal of Veterinary Medical Science
Volume: 74
Pages: 597-605
Related Report
Peer Reviewed
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[Journal Article] Persorption of IgG-Fc-coated particulates form intestinal lumen into portal blood via villous columnar epithelial cells in rat small intestine.2012
Author(s)
Yuji, M., Fujimoto, M., Qi, W.-M., Takahara, E., Mantani, Y., Udayanga, K. G. S., Takeuchi, T., Warita, K., Yokoyama, T., Hoshi, N., Kitagawa, H.
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Journal Title
The Journal of Veterinary Medical Science
Volume: 74
Pages: 1447-1452
Related Report
Peer Reviewed
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[Journal Article] Alteration in the Apoptosis Process of Rat Esophageal Epithelium with Hyperproliferation of Indigenous Bacteria under a Physiological Condition2012
Author(s)
Udayanga, K. G. S., Yamamoto, K., Miyata, H., Yokoo, Y., Mantani, Y., Takahara, E., Qi, W.-M., Kawano, Yokoyama, T., J., Hoshi, N., Kitagawa, H.
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Journal Title
Journal of Veterinary Medical Science
Volume: 74
Issue: 5
Pages: 597-605
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed
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[Journal Article] Immunohistochemical Study on the Secretory Host Defense System of Bactericidal Peptides in Rat Digestive Organs2011
Author(s)
Yokoo, Y., Miyata, H., Udayanga, K. G. S., Qi, W.-M., Takahara, E., Yokoyama, T., Kawano, J., Hoshi, N., Kitagawa, H.
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Journal Title
Journal of Veterinary Medical Science
Volume: 73
Issue: 2
Pages: 217-225
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed
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[Journal Article] Immunohistochemical and Histoplanimetrical Study on the Spatial Relationship between the Settlement of Indigenous Bacteria and the Secretion of Bactericidal Peptides in Rat Alimentary Tract2011
Author(s)
Yokoo, Y., Miyata, H., Udayanga, K. G. S., Qi, W.-M., Takahara, E., Mantani, Y., Yokoyama, T., Kawano, J., Hoshi, N., Kitagawa, H.
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Journal Title
Journal of Veterinary Medical Science
Volume: 73
Issue: 8
Pages: 1043-1050
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed
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[Journal Article] Immunohistochemical Detection of Phosphatidylserine and Thrombospondin on Denucleating Erythroblasts in Rat Bone Marrow2011
Author(s)
Yokoyama, T., Etoh, T., Udayanga, K. G. S., Qi, W.-M., Warita, K., Matsumoto, Y., Miki, T., Takeuchi, Y., Hoshi, N., Kitagawa, H.
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Journal Title
Journal of Veterinary Medical Science
Volume: 73
Issue: 7
Pages: 949-952
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed
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[Journal Article] Site differences of the Toll-like receptor expression in the mucous epithelium of rat small intestine2011
Author(s)
Mantani, Y., Kamezaki, A., Udayanga, K. G. S., Takahara, E., Qi, W.-M., Yokoyama, T., Kawano, J., Hoshi, N., Kitagawa, H.
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Journal Title
Histology and Histopathology
Volume: 26
Pages: 1295-1303
URL
Related Report
Peer Reviewed
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[Journal Article] Immunohistochemical study of the apoptosis process in epidermal epithelial cells of rats under a physiological condition2011
Author(s)
Udayanga, K. G. S., Miyata, H., Yokoo, Y., Qi, W.-M., Takahara, E., Mantani, Y., Yokoyama, T., Hoshi, N., Kitagawa, H.
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Journal Title
Histology and Histopathology
Volume: 26
Pages: 811-820
URL
Related Report
Peer Reviewed
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[Journal Article] Immunohistochemical and histoplanimetrical study on the special relationship between the settlement of indigenous bacteria and the secretion of bactericidal peptides in rat alimentary tract.2011
Author(s)
Yokoo, Y., Miyata, H., Udayanga, K. G. S., Qi, W.-M., Takahara, E., Mantani, Y., Yokoyama, T., Kawano, J., Hoshi, N., Kitagawa, H.
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Journal Title
The Journal of Veterinary Medical Science
Volume: 73
Pages: 1043-1050
Related Report
Peer Reviewed
-
[Journal Article] Immunohistochemical study of the apoptosis process in epidermal epithelial cells of rats under a physiological condition.2011
Author(s)
Udayanga, K. G. S., Miyata, H., Yokoo, Y., Qi, W.-M., Takahara, E., Mantani, Y., Yokoyama, T., Hoshi, N., Kitagawa, H.
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Journal Title
Histology and Histopathology
Volume: 26
Pages: 811-820
Related Report
Peer Reviewed
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[Journal Article] Immunohistohemical detection of phosphatidylserine and thrombospondin on denucleating erythroblasts in rat bone marrow.2011
Author(s)
Yokoyama, T., Etoh, T., Udayanga, K. G. S., Takahara, E., Qi, W.-M., Warita, K., Matsumoto, Y., Miki, T., Takeuchi, T., Hoshi, N., Kitagawa, H.
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Journal Title
The Journal of Veterinary Medical Science
Volume: 73
Pages: 949-952
Related Report
Peer Reviewed
-
[Journal Article] Site defferences of Toll-like receptor expression in the mucous epithelium of rat small intestine.2011
Author(s)
Mantani, Y., Kamezaki, A., Udayanga, K. G. S., Takahara, E., Qi, W.-M., Kawano, J., Yokoyama, T., Hoshi, N., Kitagawa
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Journal Title
Histology and Histopathology
Volume: 26
Pages: 1295-1303
Related Report
Peer Reviewed
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