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Reproductive roles of the adipsin/ASP pathway mediated by immunological and lipid methabolic effects

Research Project

Project/Area Number 23580407
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionYamaguchi University

Principal Investigator

KEN TAKESHI Kusakabe  山口大学, 共同獣医学部, 准教授 (20319536)

Co-Investigator(Kenkyū-buntansha) OKADA Toshiya  大阪府立大学, 生命環境科学研究科, 教授 (00169111)
Co-Investigator(Renkei-kenkyūsha) SHIBATA Masaaki  大阪保健医療大学, 大学院・保健医療学研究科, 教授 (10319543)
Research Collaborator 武下 愛  大阪府立大学, 生命環境科学研究科, 大学院生および日本学術振興会特別研究員(DC1) (50733557)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords胎盤 / 補体 / 脂質 / 免疫 / マウス / 流産 / 脂質代謝 / 妊娠生理
Research Abstract

The adipsin/ASP system has a crosstalk effect in the processes of complement activation and cellular lipid uptaken. Involvement of adipsin/ASP system was examined in the reproductive physiology and abortion onset. In the abortion placenta, triglyceride and the related factors were elevated, and lipid droplets were increased in the vascular wall. Administration of recombinant adipsin to pregnant mice elavated abortion rate and promoted histological degeneration of the placenta. Lipid metabolic factors and pregnancy-associated cytokines were changed follwoing the adipsin treatment. Adipsin was produced mainly in the mammaly gland during pregnancy periods. It was suggested that adipsin/ASP system basically regulate lipid metabolism during pregnancy and abnormal activation could disturb normal pregnancy by systemic variation of mataboloc factors and cytokines, and by local toxic effects on the placental formation.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (44 results)

All 2014 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (26 results) Book (3 results) Remarks (10 results)

  • [Journal Article] Characteristic patterns of maternal and fetal arterial construction in the rabbit placenta.2014

    • Author(s)
      Hayashi K, Kusakabe KT, Khan H, Kuniyoshi N, Takeshita A, Hiyama M, Kano K, Kiso K.
    • Journal Title

      Med Mol Morphol

      Volume: 印刷中 Issue: 2 Pages: 76-82

    • DOI

      10.1007/s00795-013-0044-x

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of Atopic Dermatitis on Reproduction and Uterine Natural Killer Cells2014

    • Author(s)
      Hayashi K, Kusakabe KT, Sugimoto A, Wakitani S, Sugi S, Kuniyoshi N, Hiyama M, Takeshita A, Kano K, Kiso Y.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 76 Issue: 6 Pages: 913-916

    • DOI

      10.1292/jvms.13-0547

    • NAID

      130003391290

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamics and reproductive effects of complement factors in the spontaneous abortion model of CBA/J x DBA/2 mice.2014

    • Author(s)
      Takeshita A, Kusakabe KT, Hiyama M, Kuniyoshi N, Kondo T, Kano K, Kiso Y, Okada T.
    • Journal Title

      Immunobiology

      Volume: 219(5) Issue: 5 Pages: 385-391

    • DOI

      10.1016/j.imbio.2014.01.001

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression and Localization of NO Synthase Isoenzymes (iNOS and eNOS) in Development of the Rabbit Placenta2012

    • Author(s)
      Khan H
    • Journal Title

      Journal of Reproduction and Development

      Volume: 58 Issue: 2 Pages: 231-236

    • DOI

      10.1262/jrd.11-128T

    • NAID

      10030753963

    • ISSN
      0916-8818, 1348-4400
    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression and localization of NO synthase isoenzymes (iNOS and eNOS) in development of the rabbit placenta.2012

    • Author(s)
      Khan H, Kusakabe KT*, Wakitani S, Hiyama M, Takeshita A, Kiso Y.
    • Journal Title

      J Reprod Dev

      Volume: in press

    • NAID

      120005469615

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 自然流産モデルマウスの母子境界領域における母体血管構築と関連サイトカイン2013

    • Author(s)
      鳥海早紀、日下部健、武下愛、加納聖、木曾康郎
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大学(岐阜市)
    • Related Report
      2013 Final Research Report
  • [Presentation] Upregulation of complement alternative pathway in the mouse model of spontaneous abortion2013

    • Author(s)
      Ai Takeshita, Tomohiro Kondo, Kiyoshi Kano, Yasuo Kiso, Toshiya Okada, Ken Takeshi Kusakabe
    • Organizer
      46th Annual Meeting Society for the Study of Reproduction Meeting
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2013 Final Research Report
  • [Presentation] 妊娠高血圧症候群における胎盤内および血清中の補体第二経路活性2013

    • Author(s)
      武下愛、近藤友宏、加納聖、木曾康郎、岡田利也、日下部健
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      サンポートホール高松・かがわ国際会議場(高松市)
    • Related Report
      2013 Final Research Report
  • [Presentation] 自然流産モデルマウスの母子境界領域における母体血管構築と関連サイトカイン2013

    • Author(s)
      鳥海早紀、日下部 健、武下愛、加納聖、木曾康郎
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大学(岐阜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Upregulation of complement alternative pathway in the mouse model of spontaneous abortion.2013

    • Author(s)
      Ai Takeshita, Tomohiro Kondo, Kiyoshi Kano, Yasuo Kiso, Toshiya Okada, Ken Takeshi Kusakabe
    • Organizer
      46th Annual Meeting Society for the Study of Reproduction Meeting.
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2013 Annual Research Report 2012 Research-status Report
  • [Presentation] Possible roles of p53 at the feto-maternal interface during pregnancy in mice.2013

    • Author(s)
      Masato Hiyama, Ken Takeshi Kusakabe, Kiyoshi Kano, Yasuo Kiso.
    • Organizer
      46th Annual Meeting Society for the Study of Reproduction Meeting.
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2013 Annual Research Report
  • [Presentation] 妊娠高血圧症候群における胎盤内および血清中の補体第二経路活性2013

    • Author(s)
      武下愛、近藤友宏、加納聖、木曾康郎、岡田利也、日下部健
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      サンポートホール高松・かがわ国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] 自然流産モデルの母子境界領域における補体第二経路活性2012

    • Author(s)
      武下愛、鳥海早紀、吉田優司、近藤友宏、加納聖、木曾康郎、岡田利也、日下部健
    • Organizer
      第27回日本生殖免疫学会
    • Place of Presentation
      大阪医科大学(高槻市)
    • Related Report
      2013 Final Research Report
  • [Presentation] Complement activation at the feto-maternal interface in a mouse model of preeclampsia2012

    • Author(s)
      Ai Takeshita Saki Toriumi, Yuji Yoshida, Kiyoshi Kano, Tomohiro Kondo, Yasuo Kiso, Toshiya Okada, Ken Takeshi Kusakabe
    • Organizer
      The 4th Congress of the Asian Association of Veterinary Anatomist
    • Place of Presentation
      Phuket, Thailand
    • Related Report
      2013 Final Research Report
  • [Presentation] ウサギ胎盤で見られた特徴的な血管構造2012

    • Author(s)
      日下部健、林一彦、國吉信恵、加納聖、木曾康郎
    • Organizer
      日本解剖学会第67回中国・四国支部学術集会
    • Place of Presentation
      山口大学医学部(宇部市)
    • Related Report
      2013 Final Research Report
  • [Presentation] Allogenic交配の胎盤内における補体第二経路活性2012

    • Author(s)
      武下愛、鳥海早紀、吉田優司、近藤友宏、加納聖、木曾康郎、岡田利也、日下部健
    • Organizer
      日本解剖学会第67回中国・四国支部学術集会
    • Place of Presentation
      山口大学医学部(宇部市)
    • Related Report
      2013 Final Research Report
  • [Presentation] Vascular structure of the placenta in the rabbit placenta. Workshop : Comparative Placentation and Animal Models2012

    • Author(s)
      Ken Kusakabe
    • Organizer
      International Federation of Placenta Association Meeting 2012
    • Place of Presentation
      International Conference Center Hiroshima
    • Related Report
      2013 Final Research Report
  • [Presentation] CBA/J ×DBA/2自然流産モデルにおける補体第二経路の関与2012

    • Author(s)
      武下愛、鳥海早紀、吉田優司、近藤友宏、木曾康郎、岡田利也、日下部健
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      岩手大学(盛岡市)
    • Related Report
      2013 Final Research Report
  • [Presentation] CBA/J×DBA/2自然流産モデルにおける補体第二経路の関与2012

    • Author(s)
      武下愛、鳥海早紀、吉田優司、近藤友宏、木曾康郎、岡田利也、日下部健
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      岩手大学
    • Related Report
      2012 Research-status Report
  • [Presentation] Vascular structure of the placenta in the rabbit placenta.2012

    • Author(s)
      Ken Kusakabe
    • Organizer
      Workshop: Comparative Placentation and Animal Models. International Federation of Placenta Association Meeting
    • Place of Presentation
      International Conference Center Hiroshima
    • Related Report
      2012 Research-status Report
  • [Presentation] Allogenic交配の胎盤内における補体第二経路活性2012

    • Author(s)
      武下愛、鳥海早紀、吉田優司、近藤友宏、加納聖、木曾康郎、岡田利也、日下部 健
    • Organizer
      日本解剖学会第67回中国・四国支部学術集会
    • Place of Presentation
      山口大学医学部
    • Related Report
      2012 Research-status Report
  • [Presentation] ウサギ胎盤で見られた特徴的な血管構造2012

    • Author(s)
      日下部 健、林 一彦、國吉信恵、加納 聖、木曾康郎
    • Organizer
      日本解剖学会第67回中国・四国支部学術集会
    • Place of Presentation
      山口大学医学部
    • Related Report
      2012 Research-status Report
  • [Presentation] Complement activation at the feto-maternal interface in a mouse model of preeclampsia.2012

    • Author(s)
      Ai Takeshita Saki Toriumi, Yuji Yoshida, Kiyoshi Kano, Tomohiro Kondo, Yasuo Kiso, Toshiya Okada, Ken Takeshi Kusakabe.
    • Organizer
      The 4th Congress of the Asian Association of Veterinary Anatomist.
    • Place of Presentation
      Phuket, Thailand.
    • Related Report
      2012 Research-status Report
  • [Presentation] 自然流産モデルの母子境界領域における補体第二経路活性2012

    • Author(s)
      武下愛、鳥海早紀、吉田優司、近藤友宏、加納聖、木曾康郎、岡田利也、日下部健
    • Organizer
      第27回日本生殖免疫学会
    • Place of Presentation
      大阪医科大学
    • Related Report
      2012 Research-status Report
  • [Presentation] マウス自然流産胎盤における変動因子の探索と機能解析2011

    • Author(s)
      日下部健
    • Organizer
      第4回性差生物医学研究会
    • Place of Presentation
      岩手大学(盛岡市)
    • Year and Date
      2011-11-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Assessment of NO synthase isoenzymes (eNOS and iNOS) in the rabbit placenta during successful pregnancy2011

    • Author(s)
      Hamayun Khan, Ken Takeshi Kusakabe, Yasuo Kiso
    • Organizer
      第152回日本獣医学会学術集会
    • Place of Presentation
      大阪府立大学(堺市)
    • Related Report
      2013 Final Research Report
  • [Presentation] Adipsinのマウス胎盤内発現と脂質代謝への影響2011

    • Author(s)
      武下愛、永石翔太、近藤友宏、岡田利也、日下部健
    • Organizer
      第152回日本獣医学会学術集会
    • Place of Presentation
      大阪府立大学(堺市)
    • Related Report
      2013 Final Research Report
  • [Presentation] ウサギ胎盤における血管構築2011

    • Author(s)
      日下部健、林一彦、奥原由子、清時啓史、寺井恵子、檜山雅人、脇谷晶一、木曾康郎
    • Organizer
      第43回日本臨床分子形態学会学術集会
    • Place of Presentation
      大阪医科大学(高槻市)
    • Related Report
      2013 Final Research Report
  • [Presentation] Adipsinのマウス胎盤内発現と脂質代謝への影響2011

    • Author(s)
      武下愛、永石翔太、近藤友宏、岡田利也、日下部健
    • Organizer
      第152回日本獣医学会学術集会
    • Place of Presentation
      大阪府立大学 堺市
    • Related Report
      2011 Research-status Report
  • [Presentation] Assessment of NO synthase isoenzymes (eNOS and iNOS) in the rabbit placenta during successful pregnancy.2011

    • Author(s)
      Hamayun Khan, Ken Takeshi Kusakabe, Yasuo Kiso.
    • Organizer
      第152回日本獣医学会学術集会
    • Place of Presentation
      大阪府立大学 堺市
    • Related Report
      2011 Research-status Report
  • [Presentation] ウサギ胎盤における血管構築2011

    • Author(s)
      日下部健、林一彦、奥原由子、清時啓史、寺井恵子、檜山雅人、脇谷晶一、木曾康郎
    • Organizer
      第43回日本臨床分子形態学会学術集会
    • Place of Presentation
      大阪医科大学 高槻市
    • Related Report
      2011 Research-status Report
  • [Book] Renal failure-The facts. InTech-Open Access Publisher, Rijeka, Croatia2012

    • Author(s)
      Okada T, Kondo T, Takeshita A, Kusakabe KT.
    • Total Pages
      24
    • Publisher
      Effects of maternal renal dysfunction on the development of fetal kidney.
    • Related Report
      2012 Research-status Report
  • [Book] DNA microarray analysis on the murine models for endometriosis and spontaneous abortion. Marissa J. Campbell (ed) In : DNA microarrays, Synthesis and Synthetic DNA2011

    • Author(s)
      Kusakabe K, Takeshita A, Abe H, Kondo T, Okada T.
    • Publisher
      Nova Science Publishers
    • Related Report
      2013 Final Research Report
  • [Book] DNA microarray analysis on the murine models for endometriosis and spontaneous abortion. In: DNA microarrays, Synthesis and Synthetic DNA.2011

    • Author(s)
      Kusakabe K, Takeshita A, Abe H, Kondo T, Okada T.
    • Total Pages
      6
    • Publisher
      Nova Scinece Publishers, NY, USA.
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      https://www.researchgate.net/profile/Ken_Kusakabe?ev=hdr_xprf

    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://web.cc.yamaguchi-u.ac.jp/~kusakabe/

    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.vet.yamaguchi-u.ac.jp/member/kusakabe/kusakabe-p.html

    • Related Report
      2013 Final Research Report
  • [Remarks] Research gate (Ken Kusakabe)

    • URL

      https://www.researchgate.net/profile/Ken_Kusakabe?ev=hdr_xprf

    • Related Report
      2013 Annual Research Report
  • [Remarks] Research page (Ken Kusakabe)

    • URL

      http://web.cc.yamaguchi-u.ac.jp/~kusakabe/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 山口大学 共同獣医学部 教員の紹介(日下部 健)

    • URL

      http://www.vet.yamaguchi-u.ac.jp/member/kusakabe/kusakabe-p.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] Research page

    • URL

      http://web.cc.yamaguchi-u.ac.jp/~kusakabe/

    • Related Report
      2012 Research-status Report
  • [Remarks] 生体機能学講座 日下部 健

    • URL

      http://www.vet.yamaguchi-u.ac.jp/member/kusakabe/kusakabe-p.html

    • Related Report
      2012 Research-status Report
  • [Remarks] Dr. TAKESHI KUSAKABE

    • URL

      http://www.vet.yamaguchi-u.ac.jp/member/kusakabe/kusakabe-pe.html

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://web.cc.yamaguchi-u.ac.jp/~kusakabe/

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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