| Project/Area Number |
23580409
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Hiroyasu 奈良女子大学, 生活環境学部, 教授 (40183743)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 味覚受容体 / 糖尿病 / 肥満 / 味蕾 / 膵臓 / 腸 / 加齢 / 免疫組織化学 / in situ hybridization / qPCR / 行動学 / 味覚 / 機能形態学 |
|---|
| Research Abstract |
Taste receptors were firstly identified in taste buds, however, their expressions in other tissues and cells have been also suggested. The present study investigated detailed localizations and expressions of taste receptors in non-taste tissues, such as the brain, pancreas and intestine, by immunohistochemistry, Western blotting, and in situ hybridization. The present study has also demonstrated reduced sensitivity for various types of tastes in obese, diabetic and old animals as well as reduced amount of expressions of taste receptor mRNAs in diabetic animals than in control animals by behavioral and quantitative real time PCR studies.
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