| Project/Area Number |
23580420
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OSAWA Ro 神戸大学, 大学院農学研究科, 教授 (10253189)
OSAKI Makoto 独立行政法人農業・食品産業技術総合研究 機構, 動物衛生研究所, 主任研究員 (80355164)
TAKAMATSU Daisuke 独立行政法人農業・食品産業技術総合研究 機構, 動物衛生研究所, 主任研究員 (60414728)
OKURA Masatoshi 独立行政法人農業・食品産業技術総合研究 機構, 動物衛生研究所, 研究員 (60508315)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 人獣共通感染症 / 獣医細菌学 / 分子遺伝学 / レンサ球菌 / 病原因子 / ブタ / 莢膜 / 豚レンサ球菌 / 心内膜炎 / 遺伝子変異 |
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| Research Abstract |
Streptococcus suis is a bacterial pathogen that causes meningitis or endocarditis in pigs and humans. Capsule, a surface component produced by this bacterium, is an important virulence factor that inhibits phagocytosis of white blood cells. This study showed that acapsular cells of S. suis, which have sometimes been found in swine endocarditis isolates, have spontaneous mutations in capsular polysaccharide synthesis (cps) genes, and that mutations in some cps genes appeared lethal for the bacteria, whereas these lethal effects were relieved by mutations in the other cps genes. Moreover, acapsular cells showed elevated adherence to porcine and human platelets, a major virulence determinant for infective endocarditis, compared with capsular cells and the acapsular cells facilitated the incorporation of capsular cells to the biofilm formed by acapsular cells.
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