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Analysis of the mechanism that elaborate an alternative pathogenicity by loss of capsule in Streptococcus suis

Research Project

Project/Area Number 23580420
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied veterinary science
Research InstitutionThe University of Tokyo

Principal Investigator

SEKIZAKI TSUTOMU  東京大学, 農学生命科学研究科, 教授 (70355163)

Co-Investigator(Renkei-kenkyūsha) OSAWA Ro  神戸大学, 大学院農学研究科, 教授 (10253189)
OSAKI Makoto  独立行政法人農業・食品産業技術総合研究 機構, 動物衛生研究所, 主任研究員 (80355164)
TAKAMATSU Daisuke  独立行政法人農業・食品産業技術総合研究 機構, 動物衛生研究所, 主任研究員 (60414728)
OKURA Masatoshi  独立行政法人農業・食品産業技術総合研究 機構, 動物衛生研究所, 研究員 (60508315)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords人獣共通感染症 / 獣医細菌学 / 分子遺伝学 / レンサ球菌 / 病原因子 / ブタ / 莢膜 / 豚レンサ球菌 / 心内膜炎 / 遺伝子変異
Research Abstract

Streptococcus suis is a bacterial pathogen that causes meningitis or endocarditis in pigs and humans. Capsule, a surface component produced by this bacterium, is an important virulence factor that inhibits phagocytosis of white blood cells. This study showed that acapsular cells of S. suis, which have sometimes been found in swine endocarditis isolates, have spontaneous mutations in capsular polysaccharide synthesis (cps) genes, and that mutations in some cps genes appeared lethal for the bacteria, whereas these lethal effects were relieved by mutations in the other cps genes. Moreover, acapsular cells showed elevated adherence to porcine and human platelets, a major virulence determinant for infective endocarditis, compared with capsular cells and the acapsular cells facilitated the incorporation of capsular cells to the biofilm formed by acapsular cells.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (58 results)

All 2014 2013 2012 2011 Other

All Journal Article (21 results) (of which Peer Reviewed: 11 results,  Open Access: 1 results) Presentation (35 results) (of which Invited: 5 results) Book (2 results)

  • [Journal Article] Streptococcus suis serotyping by a new multiplex PCR2014

    • Author(s)
      Kerdsin A, Akeda Y, Hatrongjit R, Detchawna U, Sekizaki T, Hamada S, Gottschalk M, Oishi K.
    • Journal Title

      J Med Microbiol

      Volume: 63 Pages: 824-830

    • Related Report
      2013 Final Research Report
  • [Journal Article] Capsule loss or death : The position of mutations among capsule genes sways the destiny of Streptococcus suis2014

    • Author(s)
      Lakkitjaroen, N., Takamatsu, D., Okura, M., Sato, M., Osaki, M., and Sekizaki, T.
    • Journal Title

      FEMS Microbiol. Lett

      Volume: 354 Pages: 46-54

    • Related Report
      2013 Final Research Report
  • [Journal Article] Development of a two-step multiplex PCR assay for typing of capsular polysaccharide synthesis gene clusters of Streptococcus suis2014

    • Author(s)
      Okura, M., Lachance, C., Osaki, M., Sekizaki, T., Maruyama, F., Nozawa, T., Nakagawa, I., Hamada, S., Rossignol, C., Gottschalk, M. and Takamatsu, D.
    • Journal Title

      J. Clin. Microbiol

      Volume: 52 Pages: 1714-1719

    • Related Report
      2013 Final Research Report
  • [Journal Article] Development of a two-step multiplex PCR assay for typing of capsular polysaccharide synthesis gene clusters of Streptococcus suis2014

    • Author(s)
      Okura M, Lachance C, Osaki M, Sekizaki T, Maruyama F, Nozawa T, Nakagawa I, Hamada S, Rossignol C, Gottschalk M, Takamatsu D
    • Journal Title

      J Clin Microbiol

      Volume: 52 Issue: 5 Pages: 1714-1719

    • DOI

      10.1128/jcm.03411-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Capsule loss or death: The position of mutations among capsule genes sways the destiny of Streptococcus suis.2014

    • Author(s)
      Lakkitjaroen, N., Takamatsu, D., Okura, M., Sato, M., Osaki, M., and Sekizaki, T.
    • Journal Title

      FEMS Microbiol. Lett.

      Volume: 353 Issue: 1 Pages: 46-54

    • DOI

      10.1111/1574-6968.12428

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Streptococcus suis Serotyping by a New Multiplex PCR.2014

    • Author(s)
      Kerdsin A, Akeda Y, Hatrongjit R, Detchawna U, Sekizaki T, Hamada S, Gottschalk M, Oishi K.
    • Journal Title

      J Med Microbiol.

      Volume: 63 Issue: 6 Pages: 824-830

    • DOI

      10.1099/jmm.0.069757-0

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antimicrobial susceptibility of Streptococcus gallolyticus isolated from humans and animals2013

    • Author(s)
      Nomoto R., Tien le H.T., Sekizaki T., and Osawa R.
    • Journal Title

      Jpn J Infect Dis

      Volume: 66(4) Pages: 334-336

    • NAID

      130003381700

    • Related Report
      2013 Final Research Report
  • [Journal Article] Genetic analysis of capsular polysaccharide synthesis 1 gene clusters from all serotypes of Streptococcus suis : potential mechanisms for the generation of capsular variation2013

    • Author(s)
      Okura, M., Takamatsu, D., Maruyama, F., Nozawa, T., Nakagawa, I., Osaki, M., Sekizaki, T., Gottschalk, M., Kumagai, Y., and Hamada, S.
    • Journal Title

      Appl. Environ. Microbiol

      Volume: 79 Pages: 2796-2806

    • Related Report
      2013 Final Research Report
  • [Journal Article] Antimicrobial susceptibility of Streptococcus gallolyticus isolated from humans and animals.2013

    • Author(s)
      Nomoto R., Tien le H.T., Sekizaki T., and Osawa R.
    • Journal Title

      Jpn J Infect Dis.

      Volume: 66 Pages: 334-336

    • NAID

      130003381700

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Consumer awareness and attitude on radiocesium food contamination following Fukushima incident.2013

    • Author(s)
      Hosono, H., Kumagai, Y., and Sekizaki, T.
    • Journal Title

      J. Disaster Res.

      Volume: 8 Pages: 762-772

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analysis of capsular polysaccharide synthesis gene clusters from all serotypes of Streptococcus suis : potential mechanisms for generation of capsular variation2013

    • Author(s)
      Okura M, Takamatsu D, Maruyama F, Nozawa T, Nakagawa I, Osaki M, Sekizaki T, Gottschalk M, Kumagai Y, Hamada S
    • Journal Title

      Appl Environ Microbiol

      Volume: 79 Issue: 8 Pages: 2796-2806

    • DOI

      10.1128/aem.03742-12

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fifteen Streptococcus suis serotypes identified by multiplex PCR2012

    • Author(s)
      Anusak, K., Dejsirilert, S., Akeda, Y., Sekizaki, T., Hamada, S., Gottschalk, M., Oishi, K.
    • Journal Title

      J. Med. Microbiol

      Volume: 61 Pages: 1669-1672

    • Related Report
      2013 Final Research Report
  • [Journal Article] Streptococcus suis : an emerging biothreat2012

    • Author(s)
      Sekizaki, T.
    • Journal Title

      Journal of Disaster Research

      Volume: 7 (3) Pages: 303-312

    • Related Report
      2013 Final Research Report
  • [Journal Article] Fifteen Streptococcus suis serotypes identified by multiplex PCR.2012

    • Author(s)
      Kerdsin A
    • Journal Title

      Journal of Medical Microbiology

      Volume: 61 Issue: 12 Pages: 1669-1672

    • DOI

      10.1099/jmm.0.048587-0

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Streptococcus suis: an emerging biothreat2012

    • Author(s)
      Sekizaki, T.
    • Journal Title

      J. Disaster Res.

      Volume: 7 Pages: 303-312

    • URL

      http://www.fujipress.jp/finder/xslt.php?mode=present&inputfile=DSSTR000700030008.xml

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lineage and virulence of Streptococcus suis serotype 2 isolates from North America2011

    • Author(s)
      Fittipaldi, N., Xu, J., Lacouture, S., Tharavichitkul, P., Osaki, M., Sekizaki, T., Takamatsu, D., Gottschalk, M.
    • Journal Title

      Emerg. Infect. Dis

      Volume: 17 Pages: 2239-44

    • Related Report
      2013 Final Research Report
  • [Journal Article] Loss of capsule among Streptococcus suis isolates from porcine endocarditis and its biological significance2011

    • Author(s)
      Lakkitjaroen, N., Takamatsu, D., Okura, M., Sato, M., Osaki, M., Sekizaki, T.
    • Journal Title

      J. Med. Microbiol

      Volume: 60 Pages: 1669-1676

    • Related Report
      2013 Final Research Report
  • [Journal Article] The minor pilin subunit Sgp2 is necessary for assembly of the pilus encoded by the srtG cluster of Streptococcus suis2011

    • Author(s)
      Okura, M., Osaki, M., Fittipaldi, N., Gottschalk, M., Sekizaki, T., and Takamatsu, D.
    • Journal Title

      J. Bacteriol

      Volume: 193 Pages: 822-831

    • Related Report
      2013 Final Research Report
  • [Journal Article] Loss of capsule among Streptococcus suis isolates from porcine endocarditis and its biological significance.2011

    • Author(s)
      Lakkitjaroen, N., Takamatsu, D., Okura, M., Sato, M., Osaki, M., Sekizaki, T.
    • Journal Title

      J. Med. Microbiol.

      Volume: 60 Issue: 11 Pages: 1669-1676

    • DOI

      10.1099/jmm.0.034686-0

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The minor pilin subunit Sgp2 is necessary for assembly of the pilus encoded by the srtG cluster of Streptococcus suis.2011

    • Author(s)
      Okura, M., Osaki, M., Fittipaldi, N., Gottschalk, M., Sekizaki, T., and Takamatsu, D.
    • Journal Title

      J. Bacteriol.

      Volume: 193 Issue: 4 Pages: 822-831

    • DOI

      10.1128/jb.01555-09

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lineage and Virulence of Streptococcus suis Serotype 2 Isolates from North America.2011

    • Author(s)
      Fittipaldi, N., Xu, J., Lacouture, S., Tharavichitkul, P., Osaki, M., Sekizaki, T., Takamatsu, D., Gottschalk, M.
    • Journal Title

      Emerg. Infect. Dis.

      Volume: 17 Issue: 12 Pages: 2239-2244

    • DOI

      10.3201/eid1712.110609

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Reappraisal of the taxonomy of Streptococcus suis serotypes 20, 22, and 26 based on DNA homology2014

    • Author(s)
      野本竜平、石田沙倉、遠矢真理、関崎勉、丸山史人、大澤朗
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀(国立感染研)
    • Related Report
      2013 Final Research Report
  • [Presentation] Streptococcus suisの再分類に対応するPCR法2014

    • Author(s)
      石田沙倉、遠矢真理、野本竜平、大澤朗、関崎勉
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀(国立感染研)
    • Related Report
      2013 Final Research Report
  • [Presentation] 豚レンサ球菌莢膜糖鎖合成遺伝子領域を標的とした型別法の開発と利用2014

    • Author(s)
      大倉正稔、大崎慎人、関崎勉、丸山史人、野澤孝志、中川一路、浜田茂幸、高松大輔
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀(国立感染研)
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of a novel LAMP assay for detection of Streptococcus suis2014

    • Author(s)
      Ishida, S., Tohya, M., Nomoto, R., Osawa, R., and Sekizaki, T.
    • Organizer
      12th Japan-Korea International Symposium on Microbiology 2014
    • Place of Presentation
      Tower Hall Funabori, Tokyo, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of a novel LAMP assay for detection of Streptococcus suis.2014

    • Author(s)
      Ishida, S., Tohya, M., Nomoto, R., Osawa, R., and Sekizaki, T.
    • Organizer
      12th Japan-Korea International Symposium on Microbiology 2014
    • Place of Presentation
      Tower Hall Funabori, Tokyo
    • Related Report
      2013 Annual Research Report
  • [Presentation] Reappraisal of the taxonomy of Streptococcus suis serotypes 20, 22, and 26 based on DNA homology.2014

    • Author(s)
      野本竜平、石田沙倉、遠矢真理、関崎 勉、丸山史人、大澤 朗
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀、東京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Streptococcus suisの再分類に対応するPCR法2014

    • Author(s)
      石田沙倉、遠矢真理、野本竜平、大澤 朗、関崎 勉
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀、東京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 豚レンサ球菌莢膜糖鎖合成遺伝子領域を標的とした型別法の開発と利用2014

    • Author(s)
      大倉正稔、大崎慎人、関崎 勉、丸山史人、野澤孝志、中川一路、浜田茂幸、高松大輔
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀、東京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 豚レンサ球菌の莢膜と病原性について2013

    • Author(s)
      関崎勉
    • Organizer
      シンポジウム「グローバリズム時代の新興感染症」
    • Place of Presentation
      日本大学生物資源科学部、藤沢、神奈川
    • Related Report
      2013 Final Research Report
  • [Presentation] Loss of capsule and an alternative virulence in Streptococcus suis2013

    • Author(s)
      Sekizaki, T.
    • Organizer
      First International Workshop on Streptococcus suis
    • Place of Presentation
      Beijing, China
    • Related Report
      2013 Final Research Report
  • [Presentation] Streptococcus suis全血清型の莢膜多糖合成遺伝子クラスターの解析2013

    • Author(s)
      大倉正稔、高松大輔、丸山史人、野澤孝志、中川一路、大﨑慎人、関崎勉、熊谷由美、浜田茂幸
    • Organizer
      第22回Lancefieldレンサ球菌研究会
    • Place of Presentation
      順天堂大学、東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Gene conversions in the Streptococcus suis cps genes lead to either death or benefit for adhesiveness of the whole population2013

    • Author(s)
      Lakkitjaroen, N., Takamatsu, D., Okura, M., Sato, M., Osaki, M., and Sekizaki, T.
    • Organizer
      第22回Lancefieldレンサ球菌研究会
    • Place of Presentation
      順天堂大学、東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Streptococcus suis全血清型の莢膜関連遺伝子群の解析2013

    • Author(s)
      大倉正稔、高松大輔、丸山史人、野澤孝志、中川一路、大﨑慎人、関崎勉、浜田茂幸
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      幕張メッセ、千葉
    • Related Report
      2013 Final Research Report
  • [Presentation] Mutations in cps2J and SSU0533-0534 regions of cps2 locus are lethal for Streptococcus suis2013

    • Author(s)
      Nattakan Lakkitjaroen、高松大輔、大倉正稔、大﨑慎人、関崎勉
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      幕張メッセ、千葉
    • Related Report
      2013 Final Research Report
  • [Presentation] Loss of capsule and an alternative virulence in Streptococcus suis.2013

    • Author(s)
      Sekizaki, T.
    • Organizer
      First International Workshop on Streptococcus suis
    • Place of Presentation
      Beijing, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Streptococcus suis全血清型の莢膜多糖合成遺伝子クラスターの解析2013

    • Author(s)
      大倉正稔、高松大輔、丸山史人、野澤孝志、中川一路、大﨑慎人、関崎 勉、熊谷由美、浜田茂幸
    • Organizer
      第22回Lancefieldレンサ球菌研究会
    • Place of Presentation
      ホテル島根イン青山、東京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Gene conversions in the Streptococcus suis cps genes lead to either death or benefit for adhesiveness of the whole population.2013

    • Author(s)
      Lakkitjaroen, N., Takamatsu, D., Okura, M., Sato, M., Osaki, M., and Sekizaki, T.
    • Organizer
      第22回Lancefieldレンサ球菌研究会
    • Place of Presentation
      ホテル島根イン青山、東京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 豚レンサ球菌感染症の分子遺伝学的研究2012

    • Author(s)
      関崎勉
    • Organizer
      第5回感染病態研究フロンティア
    • Place of Presentation
      東京
    • Year and Date
      2012-08-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Surface components of Streptococcus suis2012

    • Author(s)
      Sekizaki, T.
    • Organizer
      11th Korea-Japan International Symposium on Microbiology 2012
    • Place of Presentation
      Buyeo, Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] Mutations that affect the production of capsule in Streptococcus suis2012

    • Author(s)
      Lakkitjaroen, N. Takamatsu, D., Okura, M., Osaki, M., Sekizaki, T.
    • Organizer
      第21回Lancefieldレンサ球菌研究会
    • Place of Presentation
      大阪大学、大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒトと動物に共通するレンサ球菌感染症(特別講演)2012

    • Author(s)
      関崎勉
    • Organizer
      第22回Lancefieldレンサ球菌研究会
    • Place of Presentation
      大阪大学、大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] Recent research progress in Streptococcus suis infection2012

    • Author(s)
      Sekizaki, T.
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎ブリックホール(長崎大学医学部)、長崎
    • Related Report
      2013 Final Research Report
  • [Presentation] Streptococcus suis血清型1型、2型、1/2型及び14型の莢膜合成遺伝子領域の比較解析2012

    • Author(s)
      大倉正稔,大崎慎人,関崎勉,高松大輔
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎ブリックホール(長崎大学医学部)、長崎
    • Related Report
      2013 Final Research Report
  • [Presentation] Mutations that affect the production of capsule in Streptococcus suis.2012

    • Author(s)
      Nattakan Lakkitjaroen, Daisuke Takamatsu, Masatoshi Okura, Makoto Osaki, Tsutomu Sekizaki.
    • Organizer
      第21回Lancefieldレンサ球菌研究会
    • Place of Presentation
      大阪大学、大阪府
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒトと動物に共通するレンサ球菌感染症2012

    • Author(s)
      関崎 勉
    • Organizer
      第21回Lancefieldレンサ球菌研究会
    • Place of Presentation
      大阪大学、大阪府
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Mutations in the mutational cold regions of the cps locus are lethal for Streptococcus suis2012

    • Author(s)
      Nattakan Lakkitjaroen, Daisuke Takamatsu, Masatoshi Okura, Makoto Osaki, Tsutomu Sekizaki
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      幕張メッセ、千葉県
    • Related Report
      2012 Research-status Report
  • [Presentation] Streptococcus suis全血清型の莢膜関連遺伝子群の解析2012

    • Author(s)
      大倉正稔、高松大輔、丸山史人、野澤孝志、中川一路、大崎慎人、関崎勉、浜田茂幸
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      幕張メッセ、千葉県
    • Related Report
      2012 Research-status Report
  • [Presentation] Recent research progress in Streptococcus suis infection.2012

    • Author(s)
      Tsutomu Sekizaki.
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎ブリックホール
    • Related Report
      2011 Research-status Report
  • [Presentation] Frequent loss of capsular expression in Streptococcus suis isolates from porcine endocarditis and its significance in the pathogenesis of endocarditis2011

    • Author(s)
      Lakkitjaroen, N., Takamatsu, D., Okura, M., Sato, M., Osaki, M., Sekizaki, T.
    • Organizer
      International Union of Microbial Society 2011
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Frequent loss of capsular expression in Streptococcus suis isolates from porcine endocarditis and its significance in the pathogenesis of endocarditis2011

    • Author(s)
      Lakkitjaroen, L., Takamatsu, D., Okura, M., Sato, M., Osaki, M., Sekizaki, T.
    • Organizer
      第20回Lancefieldレンサ球菌研究会
    • Place of Presentation
      愛知学院大学,名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] Frequent loss of capsular expression in Streptococcus suis isolates from porcine endocarditis and its significance in the pathogenesis of endocarditis.2011

    • Author(s)
      Nattakan Lakkitjaroen, Daisuke Takamatsu, Masatoshi Okura, Masumi Sato, Makoto Osaki, Tsutomu Sekizaki.
    • Organizer
      International Union of Microbial Society 2011
    • Place of Presentation
      Sapporo, Japan.
    • Related Report
      2011 Research-status Report
  • [Presentation] Frequent loss of capsular expression in Streptococcus suis isolates from porcine endocarditis and its significance in the pathogenesis of endocarditis.2011

    • Author(s)
      Nattakan Lakkitjaroen, Daisuke Takamatsu, Masatoshi Okura, Masumi Sato, Makoto Osaki, Tsutomu Sekizaki.
    • Organizer
      第20回Lancefieldレンサ球菌研究会
    • Place of Presentation
      愛知学院大学
    • Related Report
      2011 Research-status Report
  • [Presentation] Surface components of Streptococcus suis.

    • Author(s)
      Sekizaki, T.
    • Organizer
      11th Korea-Japan International Symposium on Microbiology
    • Place of Presentation
      Buyeo, Korea
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 豚レンサ球菌感染症の分子遺伝学的研究

    • Author(s)
      関崎 勉
    • Organizer
      第5回感染病態研究フロンティア
    • Place of Presentation
      両国第一ホテル、東京都
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 豚レンサ球菌の表層タンパクと病原性

    • Author(s)
      関崎 勉
    • Organizer
      第11回微生物研究会
    • Place of Presentation
      東京大学、東京都
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 「昨今の食中毒問題とその規制強化から学ぶもの」"生食のおいしさとリスク"一色賢司編2013

    • Author(s)
      関崎勉
    • Publisher
      エヌ・ティー・エス出版
    • Related Report
      2013 Final Research Report
  • [Book] 一色賢司編 「昨今の食中毒問題とその規制強化から学ぶもの」、”生食のおいしさとリスク”2013

    • Author(s)
      関崎 勉
    • Total Pages
      7
    • Publisher
      エヌ・ティー・エス出版
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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