The role of vector saliva in transmission of vector-borne diseases

• Project/Area Number: 23580424
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied veterinary science
• Research Institution: Hokkaido University
• Principal Investigator: KATO HIROTOMO 北海道大学, (連合)獣医学研究科, 准教授 (00346579)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: サシチョウバエ / 唾液 / リーシュマニア / 生理活性物質 / ベクター

Research Abstract

The salivary gland transcriptome analysis of Lutzomyia ayacuchensis, a vector of cutaneous leishmaniasis in Ecuadorian Andes, was performed and abundant transcripts coding for secreted proteins were identified. The most abundant transcript coded for an RGD-containing peptide was expressed in Escherichia coli and its activity was characterized. The resulting protein inhibited both platelet aggregation and blood coagulation pathway, indicating that the peptide plays an important role in the blood feeding of Lu. ayacuchensis by inhibiting host hemostasis via dual mechanisms. On the other hand, salivary nucleotidases of sand flies were assessed on their activity as an exacerbation factor for Leishmania infection. Salivary nucleotidases, PduApy and PduADA, slightly accelerated the disease progression after co-injection of Leishmania parasites, suggesting that these proteins in saliva may be partly associated with exacerbation of the disease in leishmaniasis.

Research Products

• [Journal Article] The isolation and molecular characterization of Leishmania spp. from patients with American tegumentary leishmaniasis in northwest Argentina (2014)
  • Author(s): Locatelli FM, Cajal SP, Barroso PA, Lauthier JJ, Mora MC, Juarez M, Kato H, Nasser JR, Hashiguchi Y, Korenaga M, Marco JD.
  • Journal Title: Acta Trop Volume: 131 Pages: 16-21
  • Peer Reviewed
• [Journal Article] Development of a loop-mediated isothermal amplification method for rapid mass-screening of sand flies for Leishmania infection (2014)
  • Author(s): Nzelu CO, Gomez EA, Cáceres AG, Sakurai T, Martini-Robles L, Uezato H, Mimori T, Katakura K, Hashiguchi Y, Kato H.
  • Journal Title: Acta Trop Volume: 132 Pages: 1-6
  • NAID: 120005367442
  • Peer Reviewed
• [Journal Article] Genetic diversity of Leishmania donovani/infantum complex in China through microsatellite analysis (2014)
  • Author(s): Alam MZ, Nakao R, Sakurai T, Kato H, Qu JQ, Chai JJ, Chang KP, Schönian G, Katakura K.
  • Journal Title: Infect Genet Evol Volume: 22 Pages: 112-119
  • Peer Reviewed
• [Journal Article] First detection of Leishmania tropica DNA and Trypanosoma species in Sergentomyia sand flies (Diptera : Psychodidae) from an outbreak area of cutaneous leishmaniasis in Ghana (2014)
  • Author(s): Nzelu CO, Kato H, Puplampu N, Desewu K, Odoom S, Wilson MD, Sakurai T, Katakura K, Boakye DA.
  • Journal Title: PLoS Negl Trop Dis Volume: 8
• [Journal Article] The isolation and molecular characterization of Leishmania spp. from patients with American tegumentary leishmaniasis in northwest Argentina (2014)
  • Author(s): Fabricio M. Locatelli, S. Pamela Cajal, Paola A. Barroso, Juan J. Lauthier, Maria C. Mora , Marisa Juarez, Hirotomo Kato , Julio R. Nasser, Yoshihisa Hashiguchi, Masataka Korenaga , and Jorge D. Marco
  • Journal Title: Acta Tropica Volume: 16-21 Pages: 16-21
  • DOI: 10.1016/j.actatropica.2013.11.015
  • Peer Reviewed
• [Journal Article] Development of a loop-mediated isothermal amplification method for rapid mass-screening of sand flies for Leishmania infection (2014)
  • Author(s): Ozelu, C.O., Gomez, E.A., Caceres, A.G., Sakurai, T., Martini, R.L., Uezato, H., Mimori, T., Katakura, K., Hashiguchi, Y., Kato, H.
  • Journal Title: Acta Tropica Volume: 132 Pages: 1-6
  • DOI: 10.1016/j.actatropica.2013.12.016
  • NAID: 120005367442
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Genetic diversity of Leishmania donovanl/Infantum complex in China through microsatellite analvsis. (2014)
  • Author(s): Alam, et al.
  • Journal Title: Infection Genetics and Evolution Volume: 22 Pages: 112-119
  • DOI: 10.1016/j.meegid.2014.01.019
  • Peer Reviewed
• [Journal Article] First detection of Leishmania tropica DNA and Trypanosoma species in Sergentomyia sand flies (Diptera: Psychodidae) from an outbreak area of cutaneous leishmaniasis in Ghana. (2014)
  • Author(s): Nzelu CO, Kato H, Puplampu N, Desewu K, Odoom S, Wilson MD, Sakurai T, Katakura K, Boakye DA.
  • Journal Title: PLoS Negl Trop Dis. Volume: 8 Issue: 2 Pages: e2630-e2630
  • DOI: 10.1371/journal.pntd.0002630
  • Peer Reviewed
• [Journal Article] PCR-based detection of Leishmania donovani DNA in a stray dog from a visceral leishmaniasis endemic focus in Bangladesh (2013)
  • Author(s): Alam MZ, Yasin MG, Kato H, Sakurai T, Katakura K.
  • Journal Title: J Vet Med Sci Volume: 75 Pages: 75-78
  • NAID: 130001879680
  • Peer Reviewed
• [Journal Article] Analysis of salivary gland transcripts of the sand fly Lutzomyia ayacuchensis, a vector of Andean-type cutaneous leishmaniasis (2013)
  • Author(s): Kato H, Jochim RC, Gomez EA, Uezato H, Mimori T, Korenaga M, Sakurai T, Katakura K, Valenzuela JG, Hashiguchi Y.
  • Journal Title: Infect Genet Evol Volume: 13 Pages: 56-66
  • NAID: 120005228370
  • Peer Reviewed
• [Journal Article] Seroepidemiological Study of Chagas Disease in the Southern Amazon Region of Ecuador (2013)
  • Author(s): Guevara AG, Atherton RD, Wauters MA, Vicuña Y, Nelson M, Prado J, Kato H, Calvopiña MH, Hashiguchi Y.
  • Journal Title: Trop Med Health Volume: 41 Pages: 21-25
  • NAID: 10031164632
  • Peer Reviewed
• [Journal Article] Genetic diversity of the mitochondrial cytochrome b gene in Lutzomyia spp., with special reference to Lutzomyia peruensis, a main vector of Leishmania (Viannia) peruviana in the Peruvian Andes (2013)
  • Author(s): Yamamoto K, Cáceres AG, Gomez EA, Mimori T, Iwata H, Korenaga M, Sakurai T, Katakura K, Hashiguchi Y, Kato H.
  • Journal Title: Acta Trop Volume: 126 Pages: 156-163
  • NAID: 120005228382
  • Peer Reviewed
• [Journal Article] Multilocus characterization and phylogenetic analysis of Leishmania siamensis isolated from autochthonous visceral leishmaniasis cases, southern Thailand (2013)
  • Author(s): Leelayoova S, Siripattanapipong S, Hitakarun A, Kato H, Tan-ariya P, Siriyasatien P, Osatakul S, Mungthin M.
  • Journal Title: BMC Microbiol Volume: 13 Pages: 60-60
  • Peer Reviewed
• [Journal Article] Leishmaniasis recidiva cuitis and its topical treatment in Ecuador (2013)
  • Author(s): Calvopiña M, Kato H, Hashiguchi Y.
  • Journal Title: Trop Med Health Volume: 41 Pages: 93-94
  • Peer Reviewed
• [Journal Article] First human cases of Leishmania (Viannia) naiffi infection in Ecuador and identification of its suspected vector species (2013)
  • Author(s): Kato H, Calvopiña M, Criollo H, Hashiguchi Y.
  • Journal Title: Acta Trop Volume: 128 Pages: 710-713
  • NAID: 120005367407
  • Peer Reviewed
• [Journal Article] リーシュマニア症-フィールドからラボへ、ラボからフィールドへ- (2013)
  • Author(s): 加藤大智
  • Journal Title: 獣医寄生虫学会誌 Volume: vol.12, No. 1 Pages: 21-31
• [Journal Article] First human cases of Leishmania(Viannia) naiffi infection in Ecuador and identification of its suspected vector species (2013)
  • Author(s): Hirotomo Kato, Manuel Calvopina, Hipatia Criollo, Yoshihisa Hashiguchi
  • Journal Title: Acta Tropica Volume: 128 Issue: 3 Pages: 710-713
  • DOI: 10.1016/j.actatropica.2013.09.001
  • NAID: 120005367407
  • Peer Reviewed
• [Journal Article] Multilocus characterization and phylogenetic analysis of Leishmania siamensis isolated from autochthonous visceral leishmaniasis cases, southern Thailand (2013)
  • Author(s): Leelayoova S, Siripattanapipong S, Hitakarun A, Kato H, Tan-ariya P, Siriyasatien P, Osatakul S, Mungthin M
  • Journal Title: BMC Microbiol Volume: 13 Issue: 1 Pages: 60-60
  • DOI: 10.1186/1471-2180-13-60
  • Peer Reviewed
• [Journal Article] PCR-Based Detection of <i>Leishmania donovani</i> DNA in a Stray Dog from a Visceral Leishmaniasis Endemic Focus in Bangladesh (2013)
  • Author(s): Alam, et al.
  • Journal Title: Journal of Veterinary Medical Science Volume: 75 Issue: 1 Pages: 75-78
  • DOI: 10.1292/jvms.12-0134
  • NAID: 130001879680
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed
• [Journal Article] Genotyping of sand fly species in Peruvian Andes where leishmaniasis is endemic (2012)
  • Author(s): Fujita M, Kato H, Cáceres AG, Gomez EA, Velez L, Mimori T, Zhang F, Iwata H, Korenaga M, Sakurai T, Katakura K, Hashiguchi Y.
  • Journal Title: Acta Trop Volume: 121 Pages: 93-98
  • NAID: 120003860279
  • Peer Reviewed
• [Journal Article] Application of RFLP-PCR based identification for sand fly surveillance in an area endemic for kala-azar in Mymensingh, Bangladesh (2012)
  • Author(s): Alam MS, Kato H, Fukushige M, Wagatsuma Y, Itoh M.
  • Journal Title: J Parasitol Res Volume: 2012 Pages: 467821-467821
  • Peer Reviewed
• [Journal Article] Dimiconin, a novel coagulation inhibitor from the kissing bug, Triatoma dimidiata, a vector of Chagas disease (2012)
  • Author(s): Ishimaru Y, Gomez EA, Zhang F, Martini-Robles L, Iwata H, Sakurai T, Katakura K, Hashiguchi Y, Kato H.
  • Journal Title: J Exp Biol Volume: 215 Pages: 3597-3602
  • Peer Reviewed
• [Journal Article] Involvement of CD4^+ Foxp3^+ regulatory T cells in persistence of Leishmania donovani in the liver of alymphoplastic aly/aly mice (2012)
  • Author(s): Tiwananthagorn S, Iwabuchi K, Ato M, Sakurai T, Kato H, Katakura K.
  • Journal Title: PLoS Negl Trop Dis Volume: 6
  • NAID: 120004756399
  • Peer Reviewed
• [Journal Article] Natural infections of man-biting sand flies by Leishmania and Trypanosoma species in the northern Peruvian Andes (2012)
  • Author(s): Kato H, Gomez EA, Cáceres AG, Hashiguchi Y.
  • Journal Title: 獣医寄生虫学会誌 Volume: vol.10, No.1-2 Pages: 51-51
• [Journal Article] Involvement of CD4+ Foxp3+ regulatory T cells in persistence of Leishmania donovani in the liver of alymphoplastic aly/aly mice (2012)
  • Author(s): Tiwananthagorn S, Iwabuchi K, Ato M, Sakurai T, Kato H, Katakura K
  • Journal Title: PLoS Negl Trop Dis Volume: 6 Issue: 8 Pages: 1798-1798
  • DOI: 10.1371/journal.pntd.0001798
  • NAID: 120004756399
  • Peer Reviewed
• [Journal Article] Genotyping of sand fly species in Peruvian Andes where leishmaniasis is endemic (2012)
  • Author(s): Fujita, M., Kato, H., Gaceres, A. G., Gomez, E. A., Mimori, T., Zhang, F., Iwata, H., Korenaga, M., Sakurai, T., Katakura, K. and Hashiguchi, Y.
  • Journal Title: Acta Tropica Volume: 121 Issue: 2 Pages: 93-98
  • DOI: 10.1016/j.actatropica.2011.10.004
  • NAID: 120003860279
  • Peer Reviewed
• [Journal Article] Natural infections of man-biting sand flies by Leishmania and Trypanosoma species in the northern Peruvian Andes (2012)
  • Author(s): Kato H, Gomez EA, Cáceres AG, Hashiguchi Y
  • Journal Title: Japanese Journal of Veterinary Parasitology Volume: 10 Pages: 51-51
• [Journal Article] Leishmania species identification using FTA card sampling directly from patients'cutaneous lesions in the state of Lara, Venezuela (2011)
  • Author(s): Kato H, Watanabe J, Nieto IM, Korenaga M, Hashiguchi Y.
  • Journal Title: Trans R Soc Trop Med Hyg Volume: 105 Pages: 561-567
  • Peer Reviewed
• [Journal Article] Natural infections of man-biting sand flies by Leishmania and Trypanosoma species in the northern Peruvian Andes (2011)
  • Author(s): Kato H, Gomez EA, Cáceres AG, Vargas F, Mimori T, Yamamoto K, Iwata H, Korenaga M, Velez L, Hashiguchi Y.
  • Journal Title: Vector Borne Zoonotic Dis Volume: 11 Pages: 515-521
  • Peer Reviewed
• [Journal Article] Transcriptome analysis of salivary glands of Lutzomyia ayacuchensis, a vector of leishmaniasis (2011)
  • Author(s): Kato H, Gomez EA, Jochim RC, Uezato H, Valenzuela JG, Hashiguchi Y.
  • Journal Title: 獣医寄生虫学会誌 Volume: vol.9, No.2 Pages: 175-175
• [Journal Article] Leishmania species identification using FTA card sampling directly from patients’ cutaneous lesions in the state of Lara, Venezuela. (2011)
  • Author(s): Kato H*, Watanabe J, Nieto IM, Korenaga M, Hashiguchi Y.
  • Journal Title: Trans R Soc Trop Med Hyg Volume: 105 Issue: 10 Pages: 561-567
  • DOI: 10.1016/j.trstmh.2011.05.009
  • NAID: 120003464636
  • Peer Reviewed
• [Journal Article] Transcriptome analysis of salivary glands of Lutzomyia ayacuchensis, a vector of leishmaniasis (2011)
  • Author(s): Kato H, Gomez EA, Jochim RC, Uezato H, Valenzuela3 JG, Hashiguchi Y.
  • Journal Title: Japanese Journal of Veterinary Parasitology Volume: 9 Pages: 175-175
• [Presentation] エクアドル共和国アマゾン地域におけるLeishmania (Viannia) naiffiの感染症例とそのベクターの同定 (2014)
  • Author(s): 加藤大智、Manuel Calvopiña、Hipatia Criollo、橋口義久
  • Organizer: 第83回日本寄生虫学会
  • Place of Presentation: 愛媛大学(松山市)
• [Presentation] A molecular approach to study the genetic diversity in American tegumentary leishmaniasis in northwest Argentina (2014)
  • Author(s): Locatelli Fabricio M、Lauthier Juan J、Cajal S Pamela、Ruybal Paula、Barroso Paola A、Hoyos Carlos L.、Mora María C、Juarez Marisa、Kato Hir otomo、Nasser Julio R、Hashiguchi Yoshihisa、Marco Jorge D、Krenaga Masataka
  • Organizer: 第83回日本寄生虫学会
  • Place of Presentation: 愛媛大学(松山市)
• [Presentation] Schőnian Gabriele Population genetics of Leishmania donovani/infantum complex in China by multilocus microsatellite analysis (2014)
  • Author(s): 片倉賢、Alam Mohammad、中尾亮、櫻井達也、加藤大智、Chang K-P.
  • Organizer: 第83回日本寄生虫学会
  • Place of Presentation: 愛媛大学(松山市)
• [Presentation] 2つの作用機序で止血機構を阻害するサシチョウバエ唾液腺由来RGDペプチドayadualin (2014)
  • Author(s): 加藤大智,Eduardo A. Gomez,藤田恵,石丸由佳,橋口義久
  • Organizer: 第66回日本衛生動物学会
  • Place of Presentation: 岐阜大学(岐阜市)
• [Presentation] 2つの作用機序で止血機構を阻害するサシチョウバエ唾液腺由来RGDペプチドayadualin (2014)
  • Author(s): 加藤大智，Eduardo A. Gomez，藤田恵，石丸由佳，橋口義久
  • Organizer: 第66回 日本衛生動物学会
  • Place of Presentation: 岐阜大学（岐阜市）
• [Presentation] エクアドル共和国アマゾン地域におけるLeishmania (Viannia) naiffiの感染症例とそのベクターの同定 (2014)
  • Author(s): 加藤大智、Manuel Calvopiña、Hipatia Criollo、橋口義久
  • Organizer: 第83回 日本寄生虫学会
  • Place of Presentation: 愛媛大学（松山市）
• [Presentation] A molecular approach to study the genetic diversity in American tegumentary leishmaniasis in northwest Argentina (2014)
  • Author(s): Locatelli Fabricio M、Lauthier Juan J、Cajal S Pamela、Ruybal Paula、Barroso Paola A、Hoyos Carlos L.、Mora María C、Juarez Marisa、Kato Hirotomo、Nasser Julio R、Hashiguchi Yoshihisa、Marco Jorge D、Krenaga Masataka
  • Organizer: 第83回 日本寄生虫学会
  • Place of Presentation: 愛媛大学（松山市）
• [Presentation] Population genetics of Leishmania donovani/infantum complex in China by multilocus microsatellite analysis (2014)
  • Author(s): 片倉 賢、Alam Mohammad、中尾 亮、櫻井 達也、加藤 大智、Chang K-P、Schonian Gabriele
  • Organizer: 第83回 日本寄生虫学会
  • Place of Presentation: 愛媛大学（松山市）
• [Presentation] Distribution of causative agents (Leishmania spp.) and sand fly vectors (Lutzomyia spp.) of cutaneous and mucocutaneous leishmaniasis in Ecuador (2013)
  • Author(s): Hir otomo Kato, Eduardo Gomez L., Luiggi Martini R., Jenny Muzzio Aroca, Manuel Calvopina H. and Yoshihisa Hashiguchi
  • Organizer: The XXI Latin American Congress of Parasitology
  • Place of Presentation: Centro Cívico Eloy Alfaro de Guayaqui(lグアヤキル市、エクアドル)
• [Presentation] バングラデシュにおけるイヌのバベシア感染について (2013)
  • Author(s): 寺尾将司、Mohammad Alam、Shirin Akter、中尾亮、櫻井達也、加藤大智、片倉賢
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜大学(岐阜市)
• [Presentation] サシチョウバエ唾液腺由来RGDペプチドによる血小板凝集阻害 (2013)
  • Author(s): 加藤大智、藤田恵、櫻井達也、片倉賢、橋口義久
  • Organizer: 第65回日本衛生動物学会
  • Place of Presentation: 酪農学園大学(江別市)
• [Presentation] リーシュマニア原虫媒介サシチョウバエLutozomyia ayacuchensisの唾液腺遺伝子転写産物の網羅的解析 (2013)
  • Author(s): 加藤大智,Gomez Eduardo A.,Jochim Ryan C.,上里博,三森龍之,是永正敬,櫻井達也,片倉賢,Valenzuela Jesus G.,橋口義久
  • Organizer: 第82回日本寄生虫学会
  • Place of Presentation: 東京医科歯科大学(文京区)
• [Presentation] First Molecular Identification of Leishmania major in Sergentomyia ingrami from Cutaneous Leishmaniasis Outbreak Focus in Ghana (2013)
  • Author(s): Nzelu Chukwunonso O.,Desewu Kwame,Puplampu Naiki,Ghansah Anita,櫻井達也,Adabie-Gomez Delphina A.,Wilson Michael D.,片倉賢,加藤大智,Boakye Daniel A.
  • Organizer: 第82回日本寄生虫学会
  • Place of Presentation: 東京医科歯科大学(文京区)
• [Presentation] バングラデシュの内臓リーシュマニア症流行地における野犬の調査 (2013)
  • Author(s): アラムモハマドザハンギル,アクターシリン,ヤジンエムディゴラム,中尾亮,櫻井達也,加藤大智,片倉賢
  • Organizer: 第82回日本寄生虫学会
  • Place of Presentation: 東京医科歯科大学(文京区)
• [Presentation] リーシュマニア症:フィールドからラボへ、ラボからフィールドへ (2013)
  • Author(s): 加藤大智
  • Organizer: 第155回日本獣医学会
  • Place of Presentation: 東京大学(目黒区)
  • Invited
• [Presentation] Serological and molecular evidence of Leishmania parasite in dogs of visceral (2013)
  • Author(s): Mohammad Zahangir Alam、Shirin Akter、Golam Yasin、中尾亮、櫻井達也、加藤大智、片倉賢
  • Organizer: 第155回日本獣医学会
  • Place of Presentation: 東京大学(目黒区)
• [Presentation] First Molecular Identification of Leishmania major in Sergentomyia ingrami from Cutaneous Leishmaniasis Outbreak Focus in Ghana (2013)
  • Author(s): Chukwunonso O Nzelu、Kwame Desewu、Anita Ghansah、Naiki Puplampu、櫻井達也、Delphina A Adabie-Gomez、Michael D Wilson、片倉賢、加藤大智、Daniel A Boakye
  • Organizer: 第155回日本獣医学会
  • Place of Presentation: 東京大学(目黒区)
• [Presentation] サシチョウバエLutzomyia ayacuchensis唾液腺由来の新規血小板凝集阻害物質ayadualin (2013)
  • Author(s): 加藤大智、藤田恵、櫻井達也、片倉賢、橋口義久
  • Organizer: 第155回日本獣医学会
  • Place of Presentation: 東京大学(目黒区)
• [Presentation] サシチョウバエ唾液腺由来RGDペプチドによる血小板凝集阻害 (2013)
  • Author(s): 加藤大智、藤田恵、櫻井達也、片倉賢、橋口義久
  • Organizer: 第65回 日本衛生動物学会
  • Place of Presentation: 酪農学園大学（江別市）
• [Presentation] Distribution of causative agents (Leishmania spp.) and sand fly vectors (Lutzomyia spp.) of cutaneous and mucocutaneous leishmaniasis in Ecuador (2013)
  • Author(s): Hirotomo Kato, Eduardo Gomez L., Luiggi Martini R., Jenny Muzzio Aroca, Manuel Calvopina H. and Yoshihisa Hashiguchi
  • Organizer: The XXI Latin American Congress of Parasitology
  • Place of Presentation: CENTRO C&Iacute;VICO ELOY ALFARO DE GUAYAQUIL (Guayaquil)
  • Invited
• [Presentation] バングラデシュにおけるイヌのバベシア感染について (2013)
  • Author(s): 寺尾 将司、Mohammaad Alam、Shirin Akter、中尾 亮、櫻井 達也、加藤 大智、片倉 賢
  • Organizer: 第156回 日本獣医学会
  • Place of Presentation: 岐阜大学（岐阜市）
• [Presentation] リーシュマニア症：フィールドからラボへ、ラボからフィールドへ (2013)
  • Author(s): 加藤大智
  • Organizer: 第155回 日本獣医学会
  • Place of Presentation: 東京大学（東京）
  • Invited
• [Presentation] Serological and molecular evidence of Leishmania parasite in dogs of visceral (2013)
  • Author(s): Mohammad Zahangir Alam、Shirin Akter、Md. Golam Yasin、中尾 亮、櫻井達也、加藤大智、片倉 賢
  • Organizer: 第155回 日本獣医学会
  • Place of Presentation: 東京大学（東京）
• [Presentation] First Molecular Identification of Leishmania major in Sergentomyia ingrami from Cutaneous Leishmaniasis Outbreak Focus in Ghana (2013)
  • Author(s): Chukwunonso O Nzelu、Kwame Desewu、Anita Ghansah、Naiki Puplampu、櫻井達也、Delphina A Adabie-Gomez、Michael D Wilson、片倉 賢、加藤大智、Daniel A Boakye
  • Organizer: 第155回 日本獣医学会
  • Place of Presentation: 東京大学（東京）
• [Presentation] サシチョウバエLutzomyia ayacuchensis 唾液腺由来の新規血小板凝集阻害物質 ayadualin (2013)
  • Author(s): 加藤大智、藤田 恵、櫻井達也、片倉 賢、橋口義久
  • Organizer: 第155回 日本獣医学会
  • Place of Presentation: 東京大学（東京）
• [Presentation] リーシュマニア原虫媒介サシチョウバエLutozomyia ayacuchensis の唾液腺遺伝子転写産物の網羅的解析 (2013)
  • Author(s): 加藤 大智，Gomez Eduardo A.，Jochim Ryan C.，上里 博，三森 龍之，是永 正敬，櫻井 達也，片倉 賢，Valenzuela Jesus G.，橋口 義久
  • Organizer: 第82回 日本寄生虫学会
  • Place of Presentation: 東京医科歯科大学（東京）
• [Presentation] First Molecular Identification of Leishmania major in Sergentomyia ingrami from (2013)
  • Author(s): Nzelu Chukwunonso O.，Desewu Kwame，Puplampu Naiki，Ghansah Anita，櫻井 達也，Adabie-Gomez Delphina A.，Wilson Michael D. ，片倉 賢，加藤 大智，Boakye Daniel A.
  • Organizer: 第82回 日本寄生虫学会
  • Place of Presentation: 東京医科歯科大学（東京）
• [Presentation] バングラデシュの内臓リーシュマニア症流行地における野犬の調査 (2013)
  • Author(s): アラム モハマド ザハンギル，アクター シリン，ヤジン エムディ ゴラム，中尾亮，櫻井 達也，加藤 大智，片倉 賢
  • Organizer: 第82回 日本寄生虫学会
  • Place of Presentation: 東京医科歯科大学（東京）
• [Presentation] 吸血性サシガメTriatoma dimidiata唾液腺由来の新規血液凝固阻害物質dimiconin (2012)
  • Author(s): 加藤大智,石丸由佳,張霏霏,片倉賢,橋口義久
  • Organizer: 日本衛生動物学会
  • Place of Presentation: 信州大学(上田市)
  • Year and Date: 2012-03-30
• [Presentation] Leishmania venezuelensisは独立種か? (2012)
  • Author(s): 加藤大智、渡邊純子、Iraida Mendoza Nieto、是永正敬、橋口義久
  • Organizer: 日本寄生虫学会
  • Place of Presentation: 兵庫医科大学(西宮市)
  • Year and Date: 2012-03-24
• [Presentation] 昆虫捕食性カメムシ類唾液腺の比較トランスクリプトーム解析 (2012)
  • Author(s): 岡田奈々、加藤大智、竹松葉子、小林淳
  • Organizer: 蚕糸・昆虫機能利用学術講演会
  • Place of Presentation: 九州大学(福岡市)
  • Year and Date: 2012-03-18
• [Presentation] 吸血性サシガメTriatoma dimidiata唾液腺由来の新規血液凝固阻害物質dimiconin (2012)
  • Author(s): 加藤大智、石丸由佳、櫻井達也、片倉賢、橋口義久
  • Organizer: 第154回日本獣医学会
  • Place of Presentation: 岩手大学(盛岡市)
• [Presentation] ミャンマー連邦におけるウシのピロプラズマ病の疫学調査 (2012)
  • Author(s): 櫻井達也、土佐祐輔、清水耕平、廣田淳一、近朋之、加藤大智、片倉賢
  • Organizer: 第154回日本獣医学会
  • Place of Presentation: 岩手大学(盛岡市)
• [Presentation] Genetic polymorphism of Chinese Leishmania infantum strains revealed by multilocus microsatelliteanalysis (2012)
  • Author(s): Alam Mohammad、中尾亮、櫻井達也、加藤大智、Chang K.-P.、Schőnian Gabriele、片倉賢
  • Organizer: 第154回日本獣医学会
  • Place of Presentation: 岩手大学(盛岡市)
• [Presentation] 免疫不全aly/alyマウスの内臓リーシュマニア症における肝臓内原虫存続と制御性T細胞 (2012)
  • Author(s): Tiwananthagorn Saruda、加藤大智、櫻井達也、岩渕和也、阿戸学、片倉賢
  • Organizer: 第154回日本獣医学会
  • Place of Presentation: 岩手大学(盛岡市)
• [Presentation] 吸血性サシガメTriatoma dimidiata唾液腺由来の新規血液凝固阻害物質dimiconin (2012)
  • Author(s): 加藤 大智、石丸 由佳、櫻井 達也、片倉 賢、橋口 義久
  • Organizer: 第154回 日本獣医学会
  • Place of Presentation: 岩手大学（盛岡市）
• [Presentation] ミャンマー連邦におけるウシのピロプラズマ病の疫学調査 (2012)
  • Author(s): 櫻井 達也、土佐 祐輔、清水 耕平、廣田 淳一、近 朋之、加藤 大智、片倉 賢
  • Organizer: 第154回 日本獣医学会
  • Place of Presentation: 岩手大学（盛岡市）
• [Presentation] Genetic polymorphism of Chinese Leishmania infantum strains revealed by multilocus microsatellite analysis (2012)
  • Author(s): Alam Mohammad、中尾 亮、櫻井 達也、加藤 大智、Chang K.-P.、Schönian Gabriele、片倉賢
  • Organizer: 第154回 日本獣医学会
  • Place of Presentation: 岩手大学（盛岡市）
• [Presentation] 免疫不全aly/alyマウスの内臓リーシュマニア症における肝臓内原虫存続と制御性T細胞 (2012)
  • Author(s): Tiwananthagorn Saruda、加藤 大智、櫻井 達也、岩渕 和也、阿戸 学、片倉 賢
  • Organizer: 第154回 日本獣医学会
  • Place of Presentation: 岩手大学（盛岡市）
• [Presentation] Leishmania venezuelensisは独立種か？ (2012)
  • Author(s): 加藤大智、渡邊純子、Iraida Mendoza Nieto、是永正敬、橋口義久
  • Organizer: 日本寄生虫学会
  • Place of Presentation: 兵庫医科大学（西宮市）
• [Presentation] 吸血性サシガメTriatoma dimidiata唾液腺由来の新規血液凝固阻害物質dimiconi (2012)
  • Author(s): 加藤大智，石丸由佳，張霏霏，片倉賢，橋口義久
  • Organizer: 日本衛生動物学会
  • Place of Presentation: 信州大学（上田市）
• [Presentation] 昆虫捕食性カメムシ類唾液腺の比較トランスクリプトーム解析 (2012)
  • Author(s): 岡田奈々、加藤大智、竹松葉子、小林淳
  • Organizer: 蚕糸・昆虫機能利用学術講演会
  • Place of Presentation: 九州大学（福岡市）
• [Presentation] 南米ペルーにおけるFTAカード検体を用いた皮膚リーシュマニア症の広域分子疫学調査 (2011)
  • Author(s): 加藤大智、Abraham G. Caceres、三森龍之、上里博、Lenin Velez、Eduardo A. Gomez、橋口義久
  • Organizer: 日本熱帯医学会
  • Place of Presentation: 東京大学(文京区)
  • Year and Date: 2011-11-05
• [Presentation] 媒介昆虫からみたリーシュマニア症 (2011)
  • Author(s): 加藤大智
  • Organizer: 日本皮膚科学会西部支部大会
  • Place of Presentation: 沖縄コンベンションセンター(宜野湾市)
  • Year and Date: 2011-10-08
  • Invited
• [Presentation] ペルー・アンデス地域に分布するヒト吸血性サシチョウバエにみとめられたトリパノソーマ科原虫の自然感染 (2011)
  • Author(s): 加藤大智、Eduardo A. Gomez、Abraham G. Caceres、橋口義久
  • Organizer: 日本獣医学会
  • Place of Presentation: 大阪府立大学(堺市)
  • Year and Date: 2011-09-21
• [Presentation] ペルー・アンデス地域に分布するヒト吸血性サシチョウバエにみとめられたトリパノソーマ科原虫の自然感染 (2011)
  • Author(s): 加藤大智、Eduardo A. Gomez、Abraham G. Cáceres、橋口義久
  • Organizer: 日本獣医学会
  • Place of Presentation: 大阪府立大学（堺市）
• [Presentation] 媒介昆虫からみたリーシュマニア症 (2011)
  • Author(s): 加藤大智
  • Organizer: 日本皮膚科学会 西部支部大会(招待講演)
  • Place of Presentation: 沖縄コンベンションセンター（沖縄県）
• [Presentation] 南米ペルーにおけるFTAカード検体を用いた皮膚リーシュマニア症の広域分子疫学調査 (2011)
  • Author(s): 加藤大智、Abraham G. Caceres、三森龍之、上里博、Lenin Velez、Eduardo A. Gomez、橋口義久
  • Organizer: 日本熱帯医学会
  • Place of Presentation: 東京大学（文京区）
• [Book] 皮膚リーシュマニア症病変からの診断用病原体材料の採取法寄生虫学研究:材料と方法 (2012)
  • Author(s): 三森龍之、麻生妙美、加藤大智、Eduardo A. Gomez、橋口義久
  • Publisher: 三恵社
• [Book] 寄生虫学研究：材料と方法：皮膚リーシュマニア症病変からの診断用病原体材料の採取法 (2012)
  • Author(s): 三森龍之、麻生妙美、加藤大智、Eduardo A. Gomez、橋口義久
  • Total Pages: 4
  • Publisher: 三恵社
• [Remarks]
  • URL: http://www.vetmed.hokudai.ac.jp/departmentnew/detail/pathobiological/parasitology/