The mode of infection of anti-microbial resistant Salmonella and the transmission of the determinants of the resistance.
| Project/Area Number |
23580426
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Karoku 鹿児島大学, 共同獣医学部, 教授 (00136847)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | サルモネラ / 抗菌剤耐性 / ブロイラー |
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| Research Abstract |
The study was conducted to determine the antimicrobial resistance and characterize the B-lactamase genes and the plasmids in S. Infantis isolates from broilers. In 93 (6.3%) isolates recovered, 33 (35.5%) isolates showed resistance to cefotaxime conferred by TEM-20, TEM-52 and CTX-M-25 ESBLs. In addition to ESC-resistance, eight (8.6%) isolates exhibited resistance to cefoxitin mediated by CMY-2 AmpC B-lactamase. Plasmid analysis revealed the blaTEM-20 and blaCMY2 genes were associated with IncP plasmids, blaTEM was -52 linked with a non-typable plasmid and blaCTX-M-25 was carried by an IncA/C plasmid. Resistance to streptomycin, sulfamethoxazole, and oxytetracycline encoded by the aadA1, sul1, and tetA, respectively, was found in 86 (92.5%) isolates. These data indicate that S. Infantis isolates producing ESBLs and AmpC B-lactamase have spread among broiler farms in Japan. These data demonstrated the incidence of ESC-resistant S. Infantis carrying blaTEM-52 remarkably increased.
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Report
(4 results)
Research Products
(24 results)
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[Presentation] Chronological change of resistance to β-lactams in Salmonella enterica serovar Infantis isolated from broilers in Japan2012
Author(s)
T. Chuma, D. Miyasako, H. Dahshan, T.Takayama, Y. Nakamoto, F. Shahada, M. Akiba, K. Okamoto
Organizer
3rd ASM Conference on antimicrobial resistance in zoonotic bacteria and foodborne pathogens in animals, humans, and the environment
Place of Presentation
Aix-en Provence, France
Year and Date
2012-06-26
Related Report
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