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Epidemiological study on Hepatitis E virus in wild and domestic animals

Research Project

Project/Area Number 23580427
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied veterinary science
Research InstitutionRakuno Gakuen University

Principal Investigator

HAGIWARA Katsuro  酪農学園大学, 獣医学群, 教授 (50295896)

Co-Investigator(Kenkyū-buntansha) ASAKAWA Mitsuhiko  酪農学園大学, 獣医学群, 教授 (30184138)
岡本 実  酪農学園大学, 獣医学群, 准教授 (60372877)
Co-Investigator(Renkei-kenkyūsha) OKAMOTO Minoru  酪農学園大学, 獣医学群, 准教授 (60372877)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
KeywordsE型肝炎ウイルス / 野生動物 / 疫学調査 / ブタ / ハクビシン / 病理解析
Research Abstract

We conducted an epidemiological survey of the hepatitis E virus in the wild animal. As a result, a HEV-RNA was detected in approximately 47% of individual livers out of 629 Yezo deer (Cervus nippon yesoensis) which we investigated and showed a viral gene in 12% more individual feces. Also, after investigating the palm civet (Paguma larvata) which inhabited Honshu, we detected the viral genome of 30% in feces, 53% in liver. It was suggested that a HEV habitually resided to these wild animals. Also, the deer HEV was transmitted by the experimental infection to a pig, and HEV was isolated from the feces of some individuals and confirmed infectious viral excretion from the infected deer.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (24 results)

All 2014 2013 2012 2011 Other

All Journal Article (9 results) (of which Peer Reviewed: 3 results) Presentation (15 results)

  • [Journal Article] Temporal Changes in Environmental Health Risks and Socio-Psychological Status in Areas Affected by the 2011 Tsunami in Ishinomaki2014

    • Author(s)
      Kohei Makita, Kazuto Inoshita, Taishi Kayano, Kei Uenoyama, Katsuro Hagiwara, Mitsuhiko Asakawa, Kenta Ogawa, Shin'ya Kawamura, Jun Noda, Koichiro Sera, Hitoshi Sasaki, Nobutake Nakatani, Hidetoshi Higuchi, Naohito Ishikawa, Hidetomo Iwano, Yutaka Tamura
    • Journal Title

      Environment and Pollution

      Volume: vol.3, No. 1 Pages: 1-20

    • Related Report
      2013 Final Research Report
  • [Journal Article] 北海道日高地方におけるエゾシカの内部寄生虫相および道内エゾシカ寄生日本産肝蛭の分布について2014

    • Author(s)
      森昇子、三觜慶、鈴木瑞穂、萩原克郎、浅川満彦
    • Journal Title

      北海道獣医師会雑誌

      Volume: 58 Pages: 44-47

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Mycoplasma species isolated from intramammary infection of Japanese dairy cows2013

    • Author(s)
      Higuchi H, Gondaira S, Iwano H, Hirose K, Nakajima K, Kawai K, Hagiwara K, Tamura Y, Nagahata H.
    • Journal Title

      Vet Rec

      Volume: 172 (21) Pages: 557-557

    • Related Report
      2013 Final Research Report
  • [Journal Article] 由来の異なるE型肝炎ウイルスの熱感受性の違いについて2013

    • Author(s)
      高橋一恵、大久保祐士、古木理恵、服部眞次、浦山健、坂井薫、柚木幹弘、萩原克郎、生田和良
    • Journal Title

      血液事業

      Volume: 36(3) Pages: 679-685

    • Related Report
      2013 Final Research Report
  • [Journal Article] Temporal changes in environmental health risks and socio-psychological status in areas affected by the 2011 tsunami in Ishinomaki, Japan.2013

    • Author(s)
      Makita, K., Inoshita, K., Kayano, T., Uenoyama, K., Hagiwara, K., Asakawa, M.,他10名
    • Journal Title

      Environment and Pollution

      Volume: 3(1) Issue: 1 Pages: 1-20

    • DOI

      10.5539/ep.v3n1p1

    • NAID

      120005761982

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis E virus in Norway rats (Rattus norvegicus) captured arounpig farm2012

    • Author(s)
      Kanai Y, Miyasaka S, Uyama S, Kawami S, Kato-Mori Y, Tsujikawa M, Yunoki M, Nishiyama S, Ikuta K, Hagiwara K.
    • Journal Title

      BMC Res Notes

      Volume: 5(1) Pages: 4-4

    • Related Report
      2013 Final Research Report
  • [Journal Article] Protective Role of Human Intravenous Immunoglobulin from Influenza A Virus Infection in Mice2012

    • Author(s)
      Hagiwara K, Kawami S., Kato-Mori Y., Kubota-Koketsu R., Tsujikawa M., Urayama T., Yunoki M., Takahashi K., Ikuta K.
    • Journal Title

      The Open Hematology Journal

      Volume: 6 Pages: 8-11

    • Related Report
      2013 Final Research Report
  • [Journal Article] Protective Role of Human Intravenous Immunoglobulin from Influenza A Virus Infection in Mice.2012

    • Author(s)
      Hagiwara K. et al.
    • Journal Title

      The Open Hematology Journal

      Volume: 6 Pages: 8-11

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hepatitis E virus in Norway rats (Rattus norvegicus) captured around pig farm.2012

    • Author(s)
      Kanai Y., et al.
    • Journal Title

      BMC Res Notes

      Volume: 5(1) Issue: 1 Pages: 4-4

    • DOI

      10.1186/1756-0500-5-4

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] HEV Prevention, Inactivation and Removal Strategies2013

    • Author(s)
      Mikihiro Yunoki, Katsuro Hagiwara, Kazuyoshi Ikuta
    • Organizer
      Pathogen Clean Asia Summit 2013
    • Place of Presentation
      Shanghai China
    • Related Report
      2013 Final Research Report
  • [Presentation] Significant differences of properties between model viruses and target viruses (wild type) in HAV, HEV and B19 during manufacturing processes of plasma derivatives2013

    • Author(s)
      Mikihiro Yunoki, Katsuro Hagiwara, Kazuyoshi Ikuta
    • Organizer
      Bioplasma World Asia 2013
    • Place of Presentation
      Bali, Indonesia
    • Related Report
      2013 Final Research Report
  • [Presentation] NAT法の違いによる野外サンプルからのE型肝炎ウイルスの検出感度の違い2013

    • Author(s)
      鈴木瑞穂、加藤(森)ゆうこ、浅川満彦、柚木幹弘、生田和良、萩原克郎
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] ハクビシン(Paguma larvata)におけるE型肝炎の疫学調査2012

    • Author(s)
      鈴木瑞穂、大久保聖子,川道美枝子,萩原克郎
    • Organizer
      日本野生動物医学会
    • Place of Presentation
      北里大学(青森)
    • Year and Date
      2012-08-23
    • Related Report
      2013 Final Research Report
  • [Presentation] E型肝炎ウイルス(HEV)の熱感受性の違いについて2012

    • Author(s)
      高橋一恵、大久保祐士、古木理恵、服部眞次、浦山健、坂井薫、柚木幹弘、萩原克郎、生田和良
    • Organizer
      第36回血液事業学会
    • Place of Presentation
      仙台(宮城)
    • Related Report
      2013 Final Research Report
  • [Presentation] E型肝炎ウイルス感染ラットモデルの検討と応用2012

    • Author(s)
      萩原克郎、山内佳奈恵、柚木幹弘、松浦善治、生田和良
    • Organizer
      日本ウイルス学会
    • Place of Presentation
      大阪府
    • Related Report
      2013 Final Research Report
  • [Presentation] 血漿分画製剤の血漿原料におけるHEV陽性率とHEV Genotype2012

    • Author(s)
      皆木隆男、井手野祥次、上田千晶、高橋一恵、浦山健、服部眞次、坂井薫、柚木幹弘、萩原克郎、生田和良
    • Organizer
      日本ウイルス学会
    • Place of Presentation
      大阪府
    • Related Report
      2013 Final Research Report
  • [Presentation] 由来の異なるE型肝炎ウイルスのエタノール分画における挙動2012

    • Author(s)
      高橋一恵、浦山健、服部眞次、坂井薫、柚木幹弘、萩原克郎、生田和良
    • Organizer
      日本ウイルス学会
    • Place of Presentation
      大阪府
    • Related Report
      2013 Final Research Report
  • [Presentation] NAT法の違いによる野外サンプルからのE型肝炎ウイルスの検出感度の違い2012

    • Author(s)
      鈴木瑞穂、加藤(森)ゆうこ、浅川満彦、柚木幹弘、生田和良、萩原克郎
    • Organizer
      日本ウイルス学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] 出荷齢豚におけるE型肝炎ウイルスの体内分布2011

    • Author(s)
      川見祥代、柚木幹弘、山口照英、生田和良、萩原克郎
    • Organizer
      日本獣医学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] ハクビシン(Paguma larvata)におけるE型肝炎の疫学調査

    • Author(s)
      鈴木瑞穂、他4名
    • Organizer
      日本野生動物医学会
    • Place of Presentation
      北里大学(青森)
    • Related Report
      2012 Research-status Report
  • [Presentation] E型肝炎ウイルス (HEV)の熱感受性の違いについて

    • Author(s)
      高橋 一恵、他8名
    • Organizer
      第36回血液事業学会
    • Place of Presentation
      仙台(宮城)
    • Related Report
      2012 Research-status Report
  • [Presentation] E型肝炎ウイルス感染ラットモデルの検討と応用

    • Author(s)
      萩原克郎 他4名
    • Organizer
      日本ウイルス学会
    • Place of Presentation
      大阪府
    • Related Report
      2012 Research-status Report
  • [Presentation] 血漿分画製剤の血漿原料におけるHEV陽性率とHEV Genotype

    • Author(s)
      皆木 隆男、他9名
    • Organizer
      日本ウイルス学会
    • Place of Presentation
      大阪府
    • Related Report
      2012 Research-status Report
  • [Presentation] 由来の異なるE型肝炎ウイルスのエタノール分画における挙動

    • Author(s)
      高橋 一恵、他6名
    • Organizer
      日本ウイルス学会
    • Place of Presentation
      大阪府
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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