Development of a vaccine against Echinococcus multilocularis for vectors using pupose-built experimental facilities.
| Project/Area Number |
23580433
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Hokkaido Institute of Public Health |
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Principal Investigator |
YAGI KINPEI 北海道立衛生研究所, 感染症部, 部長 (70414323)
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| Co-Investigator(Kenkyū-buntansha) |
OKU Yuzaburo 鳥取大学, 農学部・獣医学科, 教授 (60133716)
MATSUMOTO Jun 日本大学, 生物資源科学部・獣医学科, 准教授 (70296169)
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| Co-Investigator(Renkei-kenkyūsha) |
KOUGUCHI Hirokazu 北海道立衛生研究所, 感染症センター・感染症部, 研究職員 (50435567)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | エキノコックス / ワクチン / 人獣共通感染症 / 多包虫症 / 寄生虫 |
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| Research Abstract |
Mucosal immunization to the nasal cavity using tetraspanin protein was shown to be effective for alveolar echinococcosis. In order to boost immunity in the intermediate host, we examined immune-stimulation using fusion proteins with fibronectin-attachment protein (FAP) of Mycobacterium avium, of which the adjuvant effect has been reported. Further experiments were conducted using inbred mice with known susceptibility and resistance for adaptation of an intermediate host vaccine , elucidating the importance of analysis of genetic information in future vaccine applications .We also considered vaccine development for the dog, which is the definitive host for Echinococcus multilocularis and successfully established this novel route of vaccination. These findings will contribute strongly to the prevention of alveolar echinococcosis in Japan.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] A pilot study on developing mucosal vaccine against alveolar echinococcosis (AE) using recombinant tetraspanin 3: Vaccine efficacy and immunology.2012
Author(s)
Dang Z, Yagi K, Oku Y, Kouguchi H, Kajino K, Matsumoto J, Nakao R, Wakaguri H, Toyoda A, Yin H, Sugimoto C
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Journal Title
PLoS Negl Trop Dis.
Volume: e1570
NAID
Related Report
Peer Reviewed
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[Journal Article] A pilot study on developing mucosal vaccine against alveolar echinococcosis (AE) using recombinant tetraspanin 3: Vaccine efficacy and immunology2011
Author(s)
Dang Z, Yagi K, Oku Y, Kouguchi H, Kajino K, Matsumoto J, Nakao R, Wakaguri H, Toyoda A, Yin H, Sugimoto C.
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Journal Title
PLoS Negl Trop Dis
Volume: 6(3)
NAID
Related Report
Peer Reviewed
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[Journal Article] Identification of genetic loci affecting the establishment and development of Echinococcus multilocularis larvae in mice2011
Author(s)
Nakao R, Kameda Y, Kouguchi H, Matsumoto J, Dang Z, Simon AY, Torigoe D, Sasaki N, Oku Y, Sugimoto C, Agui T, Yagi K.
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Journal Title
Int J Parasitol
Volume: 41(11)
Pages: 1121-8
NAID
Related Report
Peer Reviewed
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[Journal Article] Identification of genetic loci affecting the establishment and development of Echinococcus multilocularis larvae in mice.2011
Author(s)
Nakao R, Kameda Y, Kouguchi H, Matsumoto J, Dang Z, Simon AY, Torigoe D, Sasaki N, Oku Y, Sugimoto C, Agui T, Yagi K.
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Journal Title
Int J Parasitol.
Volume: 41(11)
Pages: 1121-8
NAID
Related Report
Peer Reviewed
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