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Development of a vaccine against Echinococcus multilocularis for vectors using pupose-built experimental facilities.

Research Project

Project/Area Number 23580433
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied veterinary science
Research InstitutionHokkaido Institute of Public Health

Principal Investigator

YAGI KINPEI  北海道立衛生研究所, 感染症部, 部長 (70414323)

Co-Investigator(Kenkyū-buntansha) OKU Yuzaburo  鳥取大学, 農学部・獣医学科, 教授 (60133716)
MATSUMOTO Jun  日本大学, 生物資源科学部・獣医学科, 准教授 (70296169)
Co-Investigator(Renkei-kenkyūsha) KOUGUCHI Hirokazu  北海道立衛生研究所, 感染症センター・感染症部, 研究職員 (50435567)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsエキノコックス / ワクチン / 人獣共通感染症 / 多包虫症 / 寄生虫
Research Abstract

Mucosal immunization to the nasal cavity using tetraspanin protein was shown to be effective for alveolar echinococcosis. In order to boost immunity in the intermediate host, we examined immune-stimulation using fusion proteins with fibronectin-attachment protein (FAP) of Mycobacterium avium, of which the adjuvant effect has been reported. Further experiments were conducted using inbred mice with known susceptibility and resistance for adaptation of an intermediate host vaccine , elucidating the importance of analysis of genetic information in future vaccine applications .We also considered vaccine development for the dog, which is the definitive host for Echinococcus multilocularis and successfully established this novel route of vaccination. These findings will contribute strongly to the prevention of alveolar echinococcosis in Japan.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (23 results)

All 2013 2012 2011 Other

All Journal Article (9 results) (of which Peer Reviewed: 7 results) Presentation (14 results)

  • [Journal Article] Characterization of a Surface Glycoprotein from Echinococcus multilocularis and Its Mucosal Vaccine Potential in Dogs2013

    • Author(s)
      Kouguchi H, Matsumoto J, Nakao R, Yamano K, Oku Y, Yagi K.
    • Journal Title

      PLoS One

      Volume: 8(7)

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mucosal adjuvanticity of fibronectin-binding peptide (FBP) fused with Echinococcus multilocularis tetraspanin 3: systemic and local antibody responses2012

    • Author(s)
      Dang Z, Feng J, Yagi K, Sugimoto C, Li W, Oku Y.
    • Journal Title

      PLoS Negl Trop Dis

      Volume: 6(9)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 多包条虫の終宿主診断と感染源対策2012

    • Author(s)
      奥祐三郎
    • Journal Title

      日本獣医寄生虫学雑誌

      Volume: 11(1) Pages: 8-14

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mucosal adjuvanticity of fibronectin-binding peptide (FBP) fused with Echinococcus multilocularis tetraspanin 3: systemic and local antibody responses.2012

    • Author(s)
      Dang Z, Feng J, Yagi K, Sugimoto C, Li W, Oku Y.
    • Journal Title

      PLoS Negl Trop Dis.

      Volume: 6(9) Issue: 9 Pages: e1842-e1842

    • DOI

      10.1371/journal.pntd.0001842

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 多包条虫の終宿主診断と感染源対策.2012

    • Author(s)
      奥祐三郎
    • Journal Title

      日本獣医寄生虫学雑誌

      Volume: 11(1) Pages: 8-14

    • Related Report
      2012 Research-status Report
  • [Journal Article] A pilot study on developing mucosal vaccine against alveolar echinococcosis (AE) using recombinant tetraspanin 3: Vaccine efficacy and immunology.2012

    • Author(s)
      Dang Z, Yagi K, Oku Y, Kouguchi H, Kajino K, Matsumoto J, Nakao R, Wakaguri H, Toyoda A, Yin H, Sugimoto C
    • Journal Title

      PLoS Negl Trop Dis.

      Volume: e1570

    • NAID

      120004027251

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A pilot study on developing mucosal vaccine against alveolar echinococcosis (AE) using recombinant tetraspanin 3: Vaccine efficacy and immunology2011

    • Author(s)
      Dang Z, Yagi K, Oku Y, Kouguchi H, Kajino K, Matsumoto J, Nakao R, Wakaguri H, Toyoda A, Yin H, Sugimoto C.
    • Journal Title

      PLoS Negl Trop Dis

      Volume: 6(3)

    • NAID

      120004027251

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of genetic loci affecting the establishment and development of Echinococcus multilocularis larvae in mice2011

    • Author(s)
      Nakao R, Kameda Y, Kouguchi H, Matsumoto J, Dang Z, Simon AY, Torigoe D, Sasaki N, Oku Y, Sugimoto C, Agui T, Yagi K.
    • Journal Title

      Int J Parasitol

      Volume: 41(11) Pages: 1121-8

    • NAID

      120005133357

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of genetic loci affecting the establishment and development of Echinococcus multilocularis larvae in mice.2011

    • Author(s)
      Nakao R, Kameda Y, Kouguchi H, Matsumoto J, Dang Z, Simon AY, Torigoe D, Sasaki N, Oku Y, Sugimoto C, Agui T, Yagi K.
    • Journal Title

      Int J Parasitol.

      Volume: 41(11) Pages: 1121-8

    • NAID

      120005133357

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 多包条虫感染イヌの血清および腸管ン粘液を利用した終宿主粘膜ワクチン抗原候補の探索2013

    • Author(s)
      孝口裕一、松本淳、中尾亮、山野公明、入江隆夫、奥祐三郎、八木欣平
    • Organizer
      第59回日本寄生虫学会・日本衛生動物学会北日本支部合同大会
    • Place of Presentation
      酪農学園大学研修館(北海道江別市)
    • Year and Date
      2013-10-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 多包条虫感染マウス(感受性DBA/2と抵抗性C57BL/6)の肝臓病変部の宿主遺伝子発現2013

    • Author(s)
      奥祐三郎、水上智秋、土井純子、松本淳、孝口裕一、八木欣平
    • Organizer
      第82回日本寄生虫学会
    • Place of Presentation
      東京医科歯科大学湯島キャンパス(東京都)
    • Year and Date
      2013-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 多包条虫感染マウス(感受性DBA/2と抵抗性C57BL/6)の肝臓病変部の宿主遺伝子発現2013

    • Author(s)
      奥祐三郎、水上智秋、土井純子、松本淳、八木欣平
    • Organizer
      平成24年度日中合同シンポジウム-中国・青海省に蔓延する人獣共通寄生虫・エキノコックス3種とウシバエ類の疫学の解明と対策法の確立-
    • Place of Presentation
      ホテルメリージュ(宮崎県宮崎市)
    • Year and Date
      2013-01-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Characterization of a Surface Glycoprotein from Echinococcus multilocularis and Its Mucosal Vaccine Potential in Dogs2013

    • Author(s)
      Kouguchi H, Matsumoto J, Nakao R, Yamano K, Oku Y, Irie T. Yagi K.
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2013 Final Research Report
  • [Presentation] Characterization of a Surface Glycoprotein from Echinococcus multilocularis and Its Mucosal Vaccine Potential in Dogs2013

    • Author(s)
      Kouguchi H, Matsumoto J, Nakao R, Yamano K, Oku Y, Irie T, Yagi K.
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Vaccine development against alveolar echinococcosis using tetraspanin2012

    • Author(s)
      Dang Z, Yagi K, Li W, Sugimoto C, Oku Y.
    • Organizer
      International Symposium on Cestode Zoonoses Control
    • Place of Presentation
      上海パラダイスホテル(上海市,中華人民共和国)
    • Year and Date
      2012-10-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 北海道のエキノコックス症コントロールの現状と課題—今、どのような研究が求められているのか?-2012

    • Author(s)
      八木欣平
    • Organizer
      第6回蠕虫研究会
    • Place of Presentation
      青島サンクマール(宮崎県宮崎市)
    • Year and Date
      2012-07-28
    • Related Report
      2013 Final Research Report
  • [Presentation] エキノコックス症モデルマウスを用いた虫体発育に対する宿主抵抗性の解析2011

    • Author(s)
      中尾亮、亀田弥生、孝口裕一、松本淳、党志勝、Simon, Ayo Yila、鳥越大輔、佐々木宣哉、杉本千尋、奥祐三郎、安居院高志、八木欣平
    • Organizer
      第71回日本寄生虫学会東日本支部会
    • Place of Presentation
      杏林大学医学部(東京都三鷹市)
    • Year and Date
      2011-10-01
    • Related Report
      2013 Final Research Report
  • [Presentation] エキノコックス症モデルマウスを用いた虫体発育に対する宿主抵抗性の解析2011

    • Author(s)
      中尾 亮、亀田弥生、孝口裕一、松本 淳、党 志勝、Simon, Ayo Yila、鳥越大輔、佐々木宣哉、杉本千尋、奥 祐三郎、安居院高志、八木欣平
    • Organizer
      第71回日本寄生虫学会東日本支部会
    • Place of Presentation
      杏林大学医学部(東京都三鷹市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 多包条虫感染イヌの血清および腸管粘液を利用した終宿主粘膜ワクチン抗原候補の探索

    • Author(s)
      孝口裕一、松本淳、中尾亮、山野公明、入江隆夫、奥祐三郎、八木欣平
    • Organizer
      第59回日本寄生虫学会・日本衛生動物学会 北日本支部合同大会
    • Place of Presentation
      酪農学園大学研修館(北海道江別市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 北海道のエキノコックス症コントロールの現状と課題―今、どのような研究が求められているのか?-.

    • Author(s)
      八木欣平
    • Organizer
      第6回蠕虫研究会
    • Place of Presentation
      宮崎市、青島サンクマール
    • Related Report
      2012 Research-status Report
  • [Presentation] Vaccine development against alveolar echinococcosis using tetraspanin.

    • Author(s)
      Dang Z, Yagi K, Li W, Sugimoto C, Oku Y.
    • Organizer
      International Symposium on Cestode Zoonoses Control.
    • Place of Presentation
      上海市、中華人民共和国、上海パラダイスホテル
    • Related Report
      2012 Research-status Report
  • [Presentation] 多包条虫感染マウス(感受性DBA/2と抵抗性C57BL/6)の肝臓病変部の宿主遺伝子発現.

    • Author(s)
      奥祐三郎、水上智秋、土井純子、松本淳、八木欣平.
    • Organizer
      平成24年度日中合同シンポジウム-中国・青海省に蔓延する人獣共通寄生虫・エキノコックス3種とウシバエ類の疫学の解明と対策法の確立-
    • Place of Presentation
      宮崎市、ホテルメリージュ
    • Related Report
      2012 Research-status Report
  • [Presentation] 多包条虫感染マウス(感受性DBA/2と抵抗性C57BL/6)の肝臓病変部の宿主遺伝子発現

    • Author(s)
      奥祐三郎、水上智秋、土井純子、松本淳、孝口裕一、八木欣平.
    • Organizer
      第82回日本寄生虫学会
    • Place of Presentation
      東京都、東京医科歯科大学湯島キャンパス
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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