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Monitoring of naturally feed contamination of zearalenone in cattle herds and its preventive measures

Research Project

Project/Area Number 23580441
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Clinical veterinary science
Research InstitutionKagoshima University

Principal Investigator

TAKAGI Mitsuhiro  鹿児島大学, 獣医学部, 准教授 (40271746)

Co-Investigator(Kenkyū-buntansha) UNO Seiichi  鹿児島大学, 水産学部, 准教授 (50381140)
OTOI Takeshige  山口大学, 共同獣医学部, 教授 (30311814)
Research Collaborator JOHANNA Fink-Gremmels  ユトレヒト大学, 獣医学部, 教授
國師 恵美子  鹿児島大学, 大学院連合農学研究科
中村 正幸  鹿児島大学, 農学部, 准教授
宮本 明夫  帯広畜産大学, 畜産学研究科, 教授
出口 栄三郎  鹿児島大学, 共同獣医学部, 教授
川村 理  香川大学, 農学部, 教授
志賀 慧  鹿児島大学, 農学部獣医学科
松本 大策  (有)シェパード中央家畜診療所
蓮沼 浩  鹿児島大学, 大学院連合獣医学研究科
伏見 康生  鹿児島大学, 大学院連合獣医学研究科
岡本 光司  鹿児島県曽於農業共済組合家畜診療所
渡邊 麗 (新屋 麗)  鹿児島県曽於農業共済組合家畜診療所
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsウシ / ブタ / ゼアラレノン / 尿 / マイコトキシン吸着剤 / 繁殖性 / 家畜 / 繁殖
Outline of Final Research Achievements

We investigated effects of a commercially available mycotoxin adsorbent (MA) using Zearalenone (ZEN) contaminated herd as a model herd. The results indicate that MA supplementation has beneficial effects in reducing ZEA absorption from the intestine of cattle, reversing hepatic effects. Additionally, our field trials revealed that 1) natural ZEN contamination resulting in urine levels below the threshold value does not affect embryo production in Japanese Black and Holstein cows undergoing superovulation, and 2) the monthly (seasonally) variation of urinary ZEN concentrations existing under the standard dairy farming condition. Moreover, the effects of in vitro exposure of porcine spermatozoa to ZEN were studied by evaluating several parameters of an in vitro fertilization (IVF) system. Overall, the results indicate that prolonged exposure of boar spermatozoa to ZEN up to 1000 μg/l under reduced metabolic conditions does not affect their in vitro function.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (13 results)

All 2014 2013 2012 2011

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Journal Article] Application of mycotoxin adsorbent to cattle feed naturally contaminated with zearalenone: Urinary zearalenone excretion and association with anti-Mullerian hormone.2014

    • Author(s)
      Fushimi Y, Takagi M, Hasunuma H, Uno S, Kokushi E, Watanabe U, Liu J, Marey MA, Miyamoto A, Otoi T, Deguchi E, Fink-Gremmels J.
    • Journal Title

      World Mycotoxin Journal

      Volume: 7 Pages: 367-378

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Application of mycotoxin adsorbent to cattle feed naturally contaminated with zearalenone: Urinary zearalenone excretion and association with anti-Mullerian hormone2014

    • Author(s)
      Y. Fushimi, M. Takagi, H. Hasunuma, S. Uno, E. Kokushi, U. Watanabe, J. Liu, M. Marey, A. Miyamoto, T. Otoi, E. Deguchi, and J. Fink-Gremmels
    • Journal Title

      World Mycotoxin Journal

      Volume: In press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between urinary zearalenone concentration and embryo production in superovulated cattle2013

    • Author(s)
      M. Takagi, T. Hirai, S. Shiga, S. Uno, E. Kokushi, T. Otoi, E. Deguchi, C. Tshering and J. Fink- Gremmels
    • Journal Title

      Archives Animal Breeding

      Volume: 36 Issue: 1 Pages: 360366-360366

    • DOI

      10.7482/0003-9438-56-036

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Periodic Alteration in Urinary Zearalenone Excretion in a Dairy Cattle Herd2013

    • Author(s)
      M. Takagi, S. Shiga, S. Uno, E. Kokushi, T. Otoi, C. Tshering, E. Deguchi and J. Fink-Gremmels
    • Journal Title

      Animal Nutrition and Feed Technology

      Volume: 13 Pages: 303310-303310

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of long-term in vitro exposure of ejaculated boar sperm to zearalenone and α-zearalenol in sperm liquid storage medium2013

    • Author(s)
      R. Sambuu, M. Takagi, Z. Namula, M. Nii, M. Taniguchi, S. Uno, E. Kokushi, C. Tshering, R. Rodrigues dos Santos, J. Fink-Gremmels and T. Otoi
    • Journal Title

      Animal Science Journal

      Volume: 84 Issue: 1 Pages: 28-34

    • DOI

      10.1111/j.1740-0929.2012.01033.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Natural contamination of dietary rice straw with zearalenone and urinary zearalenone concentrations in a cattle herd2012

    • Author(s)
      H. Hasunuma, M. Takagi, O. Kawamura, C. Taniguchi, M. Nakamura, T. Chuma, S. Uno, E. Kokushi, D. Matsumoto, C. Tshering, E. Deguchi, and J. Fink-Gremmels
    • Journal Title

      Journal of Animal Science

      Volume: 90 Pages: 1610-1616

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Natural contamination of dietary rice straw with zearalenone and urinary zearalenone concentrations in a cattle herd2012

    • Author(s)
      H. Hasunuma, M. Takagi, O. Kawamura, C. Taniguchi, M. Nakamura, T. Chuma, S. Uno, E. Kokushi, D. Matsumoto, C. Tshering, E. Deguchi, and J. Fink-Gremmels
    • Journal Title

      J Anim Sci

      Volume: In press

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of long-term in vitro exposure of ejaculated boar sperm to zearalenone and α-zearalenol in sperm liquid storage medium2012

    • Author(s)
      R. Sambuu, M. Takagi, Z. Namula, M. Nii, M. Taniguchi, S. Uno, E. Kokushi, C. Tshering, R. R. Santos, J. Fink-Gremmels and T. Otoi
    • Journal Title

      Anim Sci J

      Volume: In press

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of Exposure to Zearalenone on Porcine Oocytes and Sperm During Maturation and Fertilization In Vitro2011

    • Author(s)
      R. Sambuu, M. Takagi, Z. Namula, T. Otoi, S. Shiga, R. R. Santos and J. Fink-Gremmels
    • Journal Title

      J Reprod Dev

      Volume: 57 Pages: 547-550

    • NAID

      10029593519

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Application of mycotoxin adsorbent to cattle feed naturally contaminated with zearalenone: impact on ovarian function and serum anti-Mullerian hormone.2014

    • Author(s)
      Takagi M, Fushimi Y, Uno S, Kokushi E, Watanabe U, Liu J, Marey M, Miyamoto A, Otoi T, Deguchi E, Fink-Gremmels J
    • Organizer
      9 th International Ruminant Reproduction Symposium
    • Place of Presentation
      ホテル日航ノースランド帯広(北海道帯広市)
    • Year and Date
      2014-08-25 – 2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effects of a mycotoxin adsorbent applied with the diet to cattle being exposed to rice straw naturally contaminated with zearalenone2012

    • Author(s)
      M. Takagi,* H. Hasunuma, S. Uno, E. Kokushi, D. Matsumoto, U. Watanabe, K. Okamoto, C. Tshering, E. Deguchi, and J. Fink-Gremmels
    • Organizer
      XXVII World Buiatrics Congress 2012(世界牛病学会)
    • Place of Presentation
      リスボン(ポルトガル)
    • Related Report
      2012 Research-status Report
  • [Presentation] Natural contamination of dietary rice straw with zearalenone and urinary zearalenone concentrations in a cattle herd2012

    • Author(s)
      H. Hasunuma, M. Takagi*, O. Kawamura, C. Taniguchi, M. Nakamura, T. Chuma,S. Uno, E. Kokushi, D. Matsumoto, C. Tshering, E. Deguchi,and J. Fink-Gremmels
    • Organizer
      XXVII World Buiatrics Congress 2012(世界牛病学会)
    • Place of Presentation
      リスボン(ポルトガル)
    • Related Report
      2012 Research-status Report
  • [Presentation] 飼養環境下の牛群におけるカビ毒吸着剤の飼料添加効果2012

    • Author(s)
      蓮沼浩、髙木光博、宇野誠一、國師恵美子、松本大策、岡本光司、渡邊麗、出口栄三郎
    • Organizer
      平成24年度日本産業動物獣医学会(九州地区)
    • Place of Presentation
      宮崎
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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