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Development of peptide vaccine using nano-particle adjuvant for naturally occuring tumors in dogs

Research Project

Project/Area Number 23580443
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Clinical veterinary science
Research InstitutionKagoshima University

Principal Investigator

MOMOI YASUYUKI  鹿児島大学, 獣医学部, 教授 (40303515)

Co-Investigator(Kenkyū-buntansha) KINOSHITA Asuka (SETOGUCHI Asuka)  鹿児島大学, 共同獣医学部, 准教授 (00396813)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords犬 / 癌 / 腫瘍 / ワクチン / 癌ワクチン / アジュバント / リンパ腫
Research Abstract

TThe aim of this study is to establish new tumor vaccine for canine naturally occurring tumor. We synthesized peptides in reference to epitope of tumor specific antigens. The peptides were conjugated with keyhole limpet hemocyanin and absorbed to the surface of nano-particle (adjuvant). The resultant products successfully induced antibody production against the peptide, however, cellular immunity against the target cells was not detected. Adverse events were not observed in vaccinated dogs but the clinical benefit (objective tumor reduction) was not detected in a dog with lymphoma. We newly reported canine TRP-2 cDNA nucleotide sequence and constructed TRP-2, melan-A, CD20-GFP fusion molecule, mammalian expression plasmid. The findings obtained in this study may be helpful to establish canine tumor vaccine.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (6 results)

All 2013 Other

All Presentation (3 results) Remarks (3 results)

  • [Presentation] 犬の肥満細胞腫におけるKITの発現2013

    • Author(s)
      賓田亜以、三浦直樹、桃井康行
    • Organizer
      日本獣医内科学アカデミー2013年大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-02-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 犬の肥満細胞腫におけるKITの発現

    • Author(s)
      賓田亜以、三浦直樹、桃井康行
    • Organizer
      第34回動物臨床医学会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] 犬の肥満細胞腫におけるKITの発現

    • Author(s)
      濱田亜以、三浦直樹、桃井康行
    • Organizer
      第34回動物臨床医学会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2013 Annual Research Report
  • [Remarks] 本研究の報告は鹿児島大学リポジトリに登 録し閲覧可能である。

    • URL

      http://hdl.handle.net/10232/20878

    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.vet.kagoshima-u.ac.jp/kadai/V-Image/image/index.php?

    • Related Report
      2011 Research-status Report
  • [Remarks] 研究内容

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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