| Project/Area Number |
23580448
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Clinical veterinary science
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OSAWA Takeshi 宮崎大学, 農学部, 教授 (90302059)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 乳牛 / ケトン体 / 繁殖適期 / T細胞 / 免疫 / 受胎 / 国際情報交換 / 国際研究交流 |
|---|
| Research Abstract |
Dairy cows are at an increased risk for disorders during early lactation. At this time, there is increasing milk production, but a lag in feed intake, and this condition results in the production of the ketone body in the cows with negative energy balance. Although hyperketonemia should be minimized to prevent undesirable effects on immune function and reproduction, effect of ketone body to T cell function was investigated in this study. Increased IL-17 as a family functions as a proinflammatory cytokine that responds to the invasion of the immune system and decreased IL-4 as an anti-inflammatory cytokine that responds to the gestation were observed in the cows with hyperketonemina. In the comparison of T cell, gd T cell express strongly IL-17 mRNA and CD4+ T cell express strongly IL-4 mRNA in cows, therefore it was possible that ketone bodies induce an inappropriate immune condition for conception by activative effect to gd T cells and suppressive effect to CD4+ T cells.
|
