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The effects of various heart failure medications on heart rate variability and renin-angiotensin aldosterone system in dogs with mitral regurgitation.

Research Project

Project/Area Number 23580449
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Clinical veterinary science
Research InstitutionAzabu University

Principal Investigator

FUJII Yoko  麻布大学, 獣医学部, 教授 (10318884)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords心拍変動 / 慢性変性性房室弁疾患 / 内科治療 / 犬 / 慢性房室弁疾患
Research Abstract

The purpose of this study was to evaluate the effects of various medication used for heart failure on autonomic tone and renin-angiotensin aldosterone system (RAAS) in dogs with chronic valvular heart disease. Five dogs with experimentally induced mitral regurgitation were used. Furosemide, furosemide and pimobendan, combination of furosemide, pimobendan and enaralril, azosemide and placebo were administered in the cross-over design. Variables of heart rate variability were not significantly different among groups. Urine aldosterone creatinine ratio was increased due to furosemide, however, concurrent administration of enalapril did not seem to suppress RAAS activation. Azosemide appeared minimally influence to RAAS.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (2 results)

All 2014

All Presentation (2 results)

  • [Presentation] 心機能と心外臓器の関わり2014

    • Author(s)
      藤井洋子
    • Organizer
      JCVIM(日本獣医内科学アカデミー)
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 循環器疾患治療薬2014

    • Author(s)
      藤井洋子
    • Organizer
      獣医内科学アカデミー(JCVIM)
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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